Publications by authors named "Adrian Roth"

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Autologous Organoid-T Cell Co-Culture Platform for Modeling of Immune-Mediated Drug-Induced Liver Injury.
Fadoua El Abdellaoui Soussi, Michael Brusilovsky, Emma Buck, W Clark Bacon, Sina Dadgar, Adrian Roth

Adv Sci (Weinh)· November 2025

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In silico & in vitro approaches suggest osteoclastogenesis induction underlying fractures in Entrectinib-treated children.
Sabrina Ehnert, Andreas K Nüssler, Kevin A Schulz, Alison Cardenas, Georgina Meneses-Lorente, Adrian Roth

Arch Toxicol· October 2025

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iPSC-hepatocyte organoids as a novel platform to predict AAV gene therapy efficacy.
Estelle Berreur, Giacomo Lazzaroni, Cyrill Roth, Marco Zihlmann, Martina Stirn, Adrian B Roth

Mol Ther Methods Clin Dev· June 2025

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Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.
Uwe Marx, Sonja Beken, Zaozao Chen, Eva-Maria Dehne, Ann Doherty, Adrian Roth

ALTEX· April 2025

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Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody.
Vanessa L Schumacher, Solen Pichereau, Juliana Bessa, Juergen Bachl, Sylvia Herter, Adrian Roth

Clin Transl Med· March 2025

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Age-Specific ADME Gene Expression in Infant Intestinal Enteroids.
Eva J Streekstra, Tom Scheer-Weijers, Michael Bscheider, Sabine Fuerst-Recktenwald, Adrian Roth

Mol Pharm· September 2024

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Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems.
Surat Parvatam, David Pamies, Francesca Pistollato, Sonja Beken, Indumathi Mariappan, Adrian Roth

Stem Cell Reports· January 2024

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New approach methodologies in human regulatory toxicology - Not if, but how and when!
Sebastian Schmeisser, Andrea Miccoli, Martin von Bergen, Elisabet Berggren, Albert Braeuning, Adrian Roth

Environ Int· August 2023

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The evolving role of investigative toxicology in the pharmaceutical industry.
Francois Pognan, Mario Beilmann, Harrie C M Boonen, Andreas Czich, Gordon Dear, Adrian Roth

Nat Rev Drug Discov· April 2023

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High-speed videography of transparent media using illumination-based multiplexed schlieren.
Simon Ek, Vassily Kornienko, Adrian Roth, Edouard Berrocal, Elias Kristensson

Sci Rep· November 2022

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New Drug Modalities Demand a Refined Preclinical Safety Assessment: A Call for Patient-Relevant Tissue Models.
Adrian Roth

Toxicol Sci· August 2022

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A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
Vanessa Baier, Olivia Clayton, Ramona Nudischer, Henrik Cordes, Annika R P Schneider, Adrian Roth

Clin Pharmacol Ther· November 2021

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Challenging the pipeline.
Peter Loskill, Rhiannon N Hardwick, Adrian Roth

Stem Cell Reports· September 2021

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Human microphysiological systems for drug development.
Adrian Roth,

Science· September 2021

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Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies.
S Jordan Kerns, Chaitra Belgur, Debora Petropolis, Marianne Kanellias, Riccardo Barrile, Adrian B Roth

Elife· August 2021

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Translational precision medicine: an industry perspective.
Dominik Hartl, Valeria de Luca, Anna Kostikova, Jason Laramie, Scott Kennedy, Adrian Roth

J Transl Med· June 2021

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Opportunities and challenges with microphysiological systems: a pharma end-user perspective.
Lorna Ewart, Adrian Roth

Nat Rev Drug Discov· May 2021

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FuSe: a tool to move RNA-Seq analyses from chromosomal/gene loci to functional grouping of mRNA transcripts.
Rajinder Gupta, Yannick Schrooders, Marcha Verheijen, Adrian Roth, Jos Kleinjans

Bioinformatics· April 2021

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Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.
Marianne K Vormann, Jelle Vriend, Henriëtte L Lanz, Linda Gijzen, Angelique van den Heuvel, Adrian Roth

J Pharm Sci· April 2021

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Editorial overview of the special issue on application of tissue chips in toxicology.
Ivan Rusyn, Adrian Roth

Toxicology· February 2021

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Network integration and modelling of dynamic drug responses at multi-omics levels.
Nathalie Selevsek, Florian Caiment, Ramona Nudischer, Hans Gmuender, Irina Agarkova, Adrian Roth

Commun Biol· October 2020

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Characterization of a long-term mouse primary liver 3D tissue model recapitulating innate-immune responses and drug-induced liver toxicity.
Ramona Nudischer, Kasper Renggli, Andreas Hierlemann, Adrian B Roth, Cristina Bertinetti-Lapatki

PLoS One· September 2020

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Neutrophilic infiltration in organ-on-a-chip model of tissue inflammation.
Nikolce Gjorevski, Blandine Avignon, Régine Gérard, Lauriane Cabon, Adrian B Roth

Lab Chip· September 2020

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Differential Monocyte Actuation in a Three-Organ Functional Innate Immune System-on-a-Chip.
Trevor Sasserath, John W Rumsey, Christopher W McAleer, Lee Richard Bridges, Christopher J Long, Adrian Roth

Adv Sci (Weinh)· July 2020

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Snapshot 3D reconstruction of liquid surfaces.
Adrian Roth, Elias Kristensson, Edouard Berrocal

Opt Express· June 2020

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