Publications by authors named "Alan A Melcher"

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Updates on radiotherapy-immunotherapy combinations: Proceedings of 8th Annual ImmunoRad Conference.
Fereshteh Talebi, Fabiana Gregucci, Jalal Ahmed, Nir Ben Chetrit, Brian D Brown, Alan A Melcher

Oncoimmunology· December 2025

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Xevinapant plus Chemoradiotherapy Negatively Sculpts the Tumor-Immune Microenvironment in Head and Neck Cancer.
Charleen Chan Wah Hak, Emmanuel C Patin, Anton Patrikeev, Annalisa Nicastri, Zuza Kozik, Alan A Melcher

Cancer Res Commun· November 2025

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Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial.
Magnus T Dillon, Emmanuel C Patin, Kabir Mohammed, Jeane Guevara, Simon A Smith, Alan A Melcher

Nat Commun· August 2025

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A Phase I Clinical Trial of Intrahepatic Artery Delivery of TG6002 in Combination with Oral 5-Fluorocytosine in Patients with Liver-Dominant Metastatic Colorectal Cancer.
Emma J West, Alain Sadoun, Kaidre Bendjama, Philippe Erbs, Cristina Smolenschi, Alan A Melcher

Clin Cancer Res· April 2025

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Corrigendum: Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprogramming of the tumour microenvironment.
Victoria A Jennings, Reah Rumbold-Hall, Gemma Migneco, Tyler Barr, Katrina Reilly, Alan A Melcher

Front Immunol· April 2025

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CXCL12-Targeted Immunomodulatory Gene Therapy Reduces Radiation-Induced Fibrosis in Healthy Tissues.
James T Paget, Joseph A Ward, Andrew R McKean, David C Mansfield, Martin McLaughlin, Alan A Melcher

Mol Cancer Ther· March 2025

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PBRM1 directs PBAF to pericentromeres and protects centromere integrity.
Karen A Lane, Alison Harrod, Lillian Wu, Theodoros I Roumeliotis, Hugang Feng, Alan A Melcher

Nat Commun· February 2025

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Enhancing oncolytic virotherapy by extracellular vesicle mediated microRNA reprograming of the tumour microenvironment.
Victoria A Jennings, Reah Rumbold-Hall, Gemma Migneco, Tyler Barr, Katrina Reilly, Alan A Melcher

Front Immunol· January 2025

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Sculpting the tumour microenvironment by combining radiotherapy and ATR inhibition for curative-intent adjuvant immunotherapy.
Emmanuel C Patin, Pablo Nenclares, Charleen Chan Wah Hak, Magnus T Dillon, Anton Patrikeev, Alan A Melcher

Nat Commun· August 2024

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Combination strategies incorporating oncolytic viruses and immune checkpoint inhibitors for advanced melanoma: what is the evidence?
Amarin Wongariyapak, Victoria Roulstone, Alan A Melcher, Malin Pedersen, Kevin J Harrington

Ann Transl Med· August 2023

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Enhancing anti-tumour innate immunity by targeting the DNA damage response and pattern recognition receptors in combination with radiotherapy.
Charleen M L Chan Wah Hak, Antonio Rullan, Emmanuel C Patin, Malin Pedersen, Alan A Melcher

Front Oncol· August 2022

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Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients.
Adel Samson, Emma J West, Jonathan Carmichael, Karen J Scott, Samantha Turnbull, Alan A Melcher

Cancer Immunol Res· June 2022

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Oncolytic virus treatment differentially affects the CD56 and CD56 NK cell subsets in vivo and regulates a spectrum of human NK cell activity.
Michelle Wantoch, Erica B Wilson, Alastair P Droop, Sarah L Phillips, Matt Coffey, Alan A Melcher

Immunology· May 2022

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Intravenous Oncolytic Vaccinia Virus Therapy Results in a Differential Immune Response between Cancer Patients.
Emma J West, Karen J Scott, Emma Tidswell, Kaidre Bendjama, Nicolas Stojkowitz, Alan A Melcher

Cancers (Basel)· April 2022

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Harnessing radiotherapy-induced NK-cell activity by combining DNA damage-response inhibition and immune checkpoint blockade.
Emmanuel C Patin, Magnus T Dillon, Pablo Nenclares, Lorna Grove, Heba Soliman, Alan A Melcher

J Immunother Cancer· March 2022

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An Study.
Marco Punta, Victoria A Jennings, Alan A Melcher, Stefano Lise

Front Immunol· April 2021

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Glycolysis and Fatty Acid Oxidation Inhibition Improves Survival in Glioblastoma.
Kelly J McKelvey, Erica B Wilson, Susan Short, Alan A Melcher, Michael Biggs

Front Oncol· March 2021

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Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer.
Eva Crespo-Rodriguez, Katharina Bergerhoff, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Alan A Melcher

J Immunother Cancer· August 2020

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RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma.
Henry G Smith, Kunzah Jamal, Jasbani Hs Dayal, Tencho Tenev, Joan Kyula-Currie, Alan A Melcher

EMBO Mol Med· June 2020

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Inflammatory microenvironment remodelling by tumour cells after radiotherapy.
Martin McLaughlin, Emmanuel C Patin, Malin Pedersen, Anna Wilkins, Magnus T Dillon, Alan A Melcher

Nat Rev Cancer· April 2020

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The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism.
Martin McLaughlin, Malin Pedersen, Victoria Roulstone, Katharina F Bergerhoff, Henry G Smith, Alan A Melcher

Mol Ther Oncolytics· March 2020

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.
Lorenzo Galluzzi, Ilio Vitale, Sarah Warren, Sandy Adjemian, Patrizia Agostinis, Alan A Melcher

J Immunother Cancer· March 2020

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Phase I Trial of an ICAM-1-Targeted Immunotherapeutic-Coxsackievirus A21 (CVA21) as an Oncolytic Agent Against Non Muscle-Invasive Bladder Cancer.
Nicola E Annels, David Mansfield, Mehreen Arif, Carmen Ballesteros-Merino, Guy R Simpson, Alan A Melcher

Clin Cancer Res· October 2019

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Plasmacytoid dendritic cells orchestrate innate and adaptive anti-tumor immunity induced by oncolytic coxsackievirus A21.
Louise M E Müller, Matthew Holmes, Joanne L Michael, Gina B Scott, Emma J West, Alan A Melcher

J Immunother Cancer· July 2019

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Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition.
Victoria A Jennings, Gina B Scott, Ailsa M S Rose, Karen J Scott, Gemma Migneco, Alan A Melcher

Mol Ther· June 2019

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