Publications by authors named "Alan G Benson"

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Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.
Shaun R Selness, Terri L Boehm, John K Walker, Balekudru Devadas, Richard C Durley, Alan G Benson

Bioorg Med Chem Lett· July 2011

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Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Shaun R Selness, Rajesh V Devraj, Balekudru Devadas, John K Walker, Terri L Boehm, Alan G Benson

Bioorg Med Chem Lett· July 2011

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Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.
Kevin D Jerome, Michael E Hepperle, John K Walker, Li Xing, Rajesh V Devraj, Alan G Benson

Bioorg Med Chem Lett· May 2010

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Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase.
John K Walker, Shaun R Selness, Rajesh V Devraj, Michael E Hepperle, Win Naing, Alan G Benson

Bioorg Med Chem Lett· April 2010

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Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
Robert O Hughes, D Joseph Rogier, E Jon Jacobsen, John K Walker, Alan Macinnes, Alan G Benson

J Med Chem· March 2010

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Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.
Shaun R Selness, Rajesh V Devraj, Joseph B Monahan, Terri L Boehm, John K Walker, Alan G Benson

Bioorg Med Chem Lett· October 2009

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Robert O Hughes, John K Walker, D Joseph Rogier, Steve E Heasley, Rhadika M Blevis-Bal, Alan G Benson

Bioorg Med Chem Lett· September 2009

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Robert O Hughes, John K Walker, Jerry W Cubbage, Yvette M Fobian, D Joseph Rogier, Alan G Benson

Bioorg Med Chem Lett· August 2009

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Dafydd R Owen, John K Walker, E Jon Jacobsen, John N Freskos, Robert O Hughes, Alan G Benson

Bioorg Med Chem Lett· August 2009

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Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.
Li Xing, Huey S Shieh, Shaun R Selness, Rajesh V Devraj, John K Walker, Alan G Benson

Biochemistry· July 2009

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Solid-phase total synthesis and structure proof of callipeltin B.
Ravi Krishnamoorthy, Leslie D Vazquez-Serrano, Jeffrey A Turk, Jennifer A Kowalski, Alan G Benson

J Am Chem Soc· December 2006

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Complete stereochemistry of neamphamide A and absolute configuration of the beta-methoxytyrosine residue in papuamide B.
Naoya Oku, Ravi Krishnamoorthy, Alan G Benson, Robert L Ferguson, Mark A Lipton

J Org Chem· August 2005

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