Publications by authors named "Alan Tomkinson"

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The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor.
Ashna Nagpal, Matthew A Schaich, Tyler M Weaver, Vera Roginskaya, Annahita Sallmyr, Alan E Tomkinson

Nat Commun· November 2025

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Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases.
Nicolas Call, Alan E Tomkinson

DNA Repair (Amst)· May 2025

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End Processing in NHEJ by Polymerase λ and PNKP is coordinated during short-range synapsis.
Alex Vogt, Andrea M Kaminski, Lars C Pedersen, Tasmin Naila, Alan E Tomkinson

bioRxiv· May 2025

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The zinc finger of DNA Ligase 3α binds to nucleosomes via an arginine anchor.
Bennett Van Houten, Ashna Nagpal, Matthew Schaich, Tyler Weaver, Vera Roginskaya, Alan Tomkinson

Res Sq· March 2025

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XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites.
Xiaohui Lin, Kay Sze Karina Leung, Kaitlynn F Wolfe, Nicolas Call, Seema Khattri Bhandari, Alan E Tomkinson

Nucleic Acids Res· February 2025

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Global screening of base excision repair in nucleosome core particles.
Treshaun B Sutton, Danielle L Sawyer, Tasmin Naila, Joann B Sweasy, Alan E Tomkinson

DNA Repair (Amst)· December 2024

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Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Xiaohui Lin, Dipika Gupta, Alina Vaitsiankova, Seema Khattri Bhandari, Kay Sze Karina Leung, Alan E Tomkinson

Mol Cell· October 2024

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Redundant but essential functions of PARP1 and PARP2 in DNA ligase I-independent DNA replication.
Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Alan E Tomkinson

Nucleic Acids Res· September 2024

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FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.
Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M Hegde, Alan E Tomkinson

Nat Commun· March 2024

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Inactive Parp2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts.
Xiaohui Lin, Dipika Gupta, Alina Vaitsiankova, Seema Khattri Bhandari, Kay Sze Karina Leung, Alan E Tomkinson

bioRxiv· March 2024

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Mammalian DNA ligases; roles in maintaining genome integrity.
Annahita Sallmyr, Seema Khattri Bhandari, Tasmin Naila, Alan E Tomkinson

J Mol Biol· January 2024

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The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions.
Rabeya Bilkis, Robert J Lake, Karen L Cooper, Alan Tomkinson, Hua-Ying Fan

Nucleic Acids Res· August 2023

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FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration.
Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M Hegde, Alan E Tomkinson

Res Sq· July 2023

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Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ.
Siyu Chen, Alex Vogt, Linda Lee, Tasmin Naila, Ryan McKeown, Alan E Tomkinson

Sci Adv· June 2023

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Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.
Seema Khattri Bhandari, Nathaniel Wiest, Annahita Sallmyr, Ruofei Du, Laure Ferry, Alan E Tomkinson

Sci Rep· March 2023

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Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase.
Aleksandr Sverzhinsky, Alan E Tomkinson, John M Pascal

Structure· March 2022

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Purification and Characterization of Human DNA Ligase IIIα Complexes After Expression in Insect Cells.
Ishtiaque Rashid, Miaw-Sheue Tsai, Aleksandr Sverzhinsky, Aye Su Hlaing, Brian Shih, Alan E Tomkinson

Methods Mol Biol· March 2022

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Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers.
Reem Ali, Muslim Alabdullah, Mashael Algethami, Adel Alblihy, Islam Miligy, Alan E Tomkinson

Theranostics· January 2022

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Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus.
Ishtiaque Rashid, Michal Hammel, Aleksandr Sverzhinsky, Miaw-Sheue Tsai, John M Pascal, Alan E Tomkinson

J Biol Chem· August 2021

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Structural basis of long-range to short-range synaptic transition in NHEJ.
Siyu Chen, Linda Lee, Tasmin Naila, Susan Fishbain, Annie Wang, Alan E Tomkinson

Nature· May 2021

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An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.
Michal Hammel, Ishtiaque Rashid, Aleksandr Sverzhinsky, Yasin Pourfarjam, Miaw-Sheue Tsai, Alan E Tomkinson

Nucleic Acids Res· January 2021

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Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.
Yoshihiro Matsumoto, Rhys C Brooks, Aleksandr Sverzhinsky, John M Pascal, Alan E Tomkinson

J Mol Biol· December 2020

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NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV.
Bailin Zhao, Tasmin Naila, Michael R Lieber, Alan E Tomkinson

Nucleic Acids Res· December 2020

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XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells.
Bradley J Eckelmann, Albino Bacolla, Haibo Wang, Zu Ye, Erika N Guerrero, Alan E Tomkinson

NAR Cancer· September 2020

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Human DNA ligases in replication and repair.
Annahita Sallmyr, Ishtiaque Rashid, Seema Khattri Bhandari, Tasmin Naila, Alan E Tomkinson

DNA Repair (Amst)· September 2020

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