Publications by authors named "Aled Edwards"

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Enantioselective protein affinity selection mass spectrometry (E-ASMS).
Xiaoyun Wang, Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, Aled M Edwards

Nat Commun· December 2025

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Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders.
James Wellnitz, Shabbir Ahmad, Nabin Bagale, Xuemin Cheng, Jermiah Joseph, Aled M Edwards

J Med Chem· October 2025

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Protein-ligand data at scale to support machine learning.
Aled M Edwards, Dafydd R Owen,

Nat Rev Chem· September 2025

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High-Affinity, Structure-Validated and Selective Macrocyclic Peptide Tools for Chemical Biology Studies of Huntingtin.
Esther Wolf, Rebeka Fanti, Tatsuya Ikenoue, Justin C Deme, Swati Balakrishnan, Aled M Edwards

bioRxiv· August 2025

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A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence.
Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Sara González Bolívar, Aled M Edwards

F1000Res· July 2025

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CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.
Oleksandra Herasymenko, Madhushika Silva, Abd Al-Aziz A Abu-Saleh, Ayaz Ahmad, Jesus Alvarado-Huayhuaz, Aled Edwards

J Chem Inf Model· July 2025

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A consensus platform for antibody characterization.
Riham Ayoubi, Joel Ryan, Sara Gonzalez Bolivar, Charles Alende, Vera Ruiz Moleon, Aled M Edwards

Nat Protoc· June 2025

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Structural basis of TMPRSS11D specificity and autocleavage activation.
Bryan J Fraser, Ryan P Wilson, Sára Ferková, Olzhas Ilyassov, Jackie Lac, Aled Edwards

Nat Commun· May 2025

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Enantioselective Protein Affinity Selection Mass Spectrometry (E-ASMS).
Xiaoyun Wang, Jianxian Sun, Shabbir Ahmad, Diwen Yang, Fengling Li, Aled M Edwards

bioRxiv· April 2025

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High-throughput protein target mapping enables accelerated bioactivity discovery for ToxCast and PFAS compounds.
Diwen Yang, Xiaoyun Wang, Jiabao Liu, Yufeng Gong, Pranav Nair, Aled M Edwards

bioRxiv· March 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Aled M Edwards

RSC Med Chem· February 2025

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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.
Suzanne Ackloo, Fengling Li, Magda Szewczyk, Almagul Seitova, Peter Loppnau, Aled M Edwards

J Med Chem· January 2025

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The Chemical Probes Portal - 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research.
Domenico Sanfelice, Albert A Antolin, Alisa Crisp, Yi Chen, Benjamin Bellenie, Aled Edwards

Nucleic Acids Res· January 2025

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CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein.
Fengling Li, Suzanne Ackloo, Cheryl H Arrowsmith, Fuqiang Ban, Christopher J Barden, Aled Edwards

J Chem Inf Model· November 2024

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A data science roadmap for open science organizations engaged in early-stage drug discovery.
Kristina Edfeldt, Aled M Edwards, Ola Engkvist, Judith Günther, Matthew Hartley

Nat Commun· July 2024

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Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
Riham Ayoubi, Joel Ryan, Michael S Biddle, Walaa Alshafie, Maryam Fotouhi, Aled M Edwards

Elife· November 2023

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Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
Riham Ayoubi, Joel Ryan, Michael S Biddle, Walaa Alshafie, Maryam Fotouhi, Aled M Edwards

bioRxiv· August 2023

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Target 2035 - an update on private sector contributions.
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock, Aled M Edwards

RSC Med Chem· June 2023

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Open drug discovery in Alzheimer's disease.
Alison D Axtman, Paul E Brennan, Tristan Frappier-Brinton, Ranjita Betarbet, Gregory W Carter, Aled M Edwards

Alzheimers Dement (N Y)· May 2023

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The Chemical Probes Portal: an expert review-based public resource to empower chemical probe assessment, selection and use.
Albert A Antolin, Domenico Sanfelice, Alisa Crisp, Eloy Villasclaras Fernandez, Ioan L Mica, Aled Edwards

Nucleic Acids Res· January 2023

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Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescence.
Walaa Alshafie, Maryam Fotouhi, Irina Shlaifer, Riham Ayoubi, Aled M Edwards

F1000Res· December 2022

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An open source plant kinase chemogenomics set.
Maria Florencia Ercoli, Priscila Zonzini Ramos, Rashmi Jain, Joseph Pilotte, Oliver Xiaoou Dong, Aled M Edwards

Plant Direct· November 2022

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A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria.
Rebeka C Fanti, Stanley N S Vasconcelos, Carolina M C Catta-Preta, Jaryd R Sullivan, Gustavo P Riboldi, Aled M Edwards

ACS Infect Dis· August 2022

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CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding.
Suzanne Ackloo, Rima Al-Awar, Rommie E Amaro, Cheryl H Arrowsmith, Hatylas Azevedo, Aled M Edwards

Nat Rev Chem· April 2022

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Stopping pandemics before they start: Lessons learned from SARS-CoV-2.
Aled M Edwards, Ralph S Baric, Erica Ollmann Saphire, Jeffrey B Ulmer

Science· March 2022

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