Publications by authors named "Alessandro Vacchini"

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Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking.
Chiara Lecchi, Alessandro Vacchini, Stefano Sainas, Marco L Lolli, Matthew Luedtke

bioRxiv· June 2025

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Recognition of MR1-antigen complexes by TCR Vγ9Vδ2.
José Pedro Loureiro, Alessandro Vacchini, Giuliano Berloffa, Jan Devan, Verena Schaefer

Front Immunol· May 2025

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Mitochondria regulate MR1 protein expression and produce self-metabolites that activate MR1-restricted T cells.
Gennaro Prota, Giuliano Berloffa, Wael Awad, Alessandro Vacchini, Andrew Chancellor

Proc Natl Acad Sci U S A· May 2025

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The carbonyl nucleobase adduct MAde is a potent antigen for adaptive polyclonal MR1-restricted T cells.
Andrew Chancellor, Daniel Constantin, Giuliano Berloffa, Qinmei Yang, Vladimir Nosi, Alessandro Vacchini

Immunity· February 2025

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MR1 Gene and Protein Expression Are Enhanced by Inhibition of the Extracellular Signal-Regulated Kinase ERK.
Daniel Constantin, Vladimir Nosi, Natalie Kehrer, Alessandro Vacchini, Andrew Chancellor

Cancer Immunol Res· October 2024

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Nucleobase adducts bind MR1 and stimulate MR1-restricted T cells.
Alessandro Vacchini, Andrew Chancellor, Qinmei Yang, Rodrigo Colombo, Julian Spagnuolo

Sci Immunol· May 2024

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Surface protein and functional analyses identify CD4+CD39+ TCR αβ+ and activated TCR Vδ1+ cells with distinct pro-inflammatory functions in Crohn's disease lesions.
Jan Devan, Vladimir Nosi, Julian Spagnuolo, Andrew Chancellor, Aisha Beshirova, Alessandro Vacchini

Clin Exp Immunol· January 2024

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Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.
Andrew Chancellor, Robert Alan Simmons, Rahul C Khanolkar, Vladimir Nosi, Aisha Beshirova, Alessandro Vacchini

J Exp Med· September 2023

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Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome.
Rajesh Kumar, Samantha Milanesi, Martyna Szpakowska, Laura Dotta, Dario Di Silvestre, Alessandro Vacchini

JCI Insight· March 2023

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Phosphoproteomic mapping of CCR5 and ACKR2 signaling properties.
Alessandro Vacchini, Elisa Maffioli, Dario Di Silvestre, Cinzia Cancellieri, Samantha Milanesi

Front Mol Biosci· November 2022

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MR1, an immunological periscope of cellular metabolism.
Andrew Chancellor, Alessandro Vacchini, Gennaro De Libero

Int Immunol· February 2022

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MR1-Restricted T Cells Are Unprecedented Cancer Fighters.
Alessandro Vacchini, Andrew Chancellor, Julian Spagnuolo, Lucia Mori, Gennaro De Libero

Front Immunol· March 2021

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Endogenous modification of the chemoattractant CXCL5 alters receptor usage and enhances its activity toward neutrophils and monocytes.
Mieke Metzemaekers, Anneleen Mortier, Alessandro Vacchini, Daiane Boff, Karen Yu

Sci Signal· March 2021

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Isolation and Characterization of MAIT Cells from Human Tissue Biopsies.
Daniela Di Blasi, Alessandro Vacchini, Gennaro De Libero, Lucia Mori

Methods Mol Biol· January 2021

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Control of Cytoskeletal Dynamics by β-Arrestin1/Myosin Vb Signaling Regulates Endosomal Sorting and Scavenging Activity of the Atypical Chemokine Receptor ACKR2.
Alessandro Vacchini, Cinzia Cancellieri, Samantha Milanesi, Sabrina Badanai, Benedetta Savino

Vaccines (Basel)· September 2020

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Differential Effects of Posttranslational Modifications of CXCL8/Interleukin-8 on CXCR1 and CXCR2 Internalization and Signaling Properties.
Alessandro Vacchini, Anneleen Mortier, Paul Proost, Massimo Locati, Mieke Metzemaekers

Int J Mol Sci· November 2018

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Analysis of G Protein and β-Arrestin Activation in Chemokine Receptors Signaling.
Alessandro Vacchini, Marta Busnelli, Bice Chini, Massimo Locati, Elena Monica Borroni

Methods Enzymol· November 2017

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Overview and potential unifying themes of the atypical chemokine receptor family.
Alessandro Vacchini, Massimo Locati, Elena Monica Borroni

J Leukoc Biol· June 2016

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Pituitary Adenoma and the Chemokine Network: A Systemic View.
Fabio Grizzi, Elena Monica Borroni, Alessandro Vacchini, Dorina Qehajaj, Manuela Liguori

Front Endocrinol (Lausanne)· October 2015

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Review: Structure-function and biological properties of the atypical chemokine receptor D6.
Cinzia Cancellieri, Nicoletta Caronni, Alessandro Vacchini, Benedetta Savino, Elena M Borroni

Mol Immunol· August 2013

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β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
Elena M Borroni, Cinzia Cancellieri, Alessandro Vacchini, Yann Benureau, Bernard Lagane

Sci Signal· April 2013

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Atypical chemokine receptors: from silence to sound.
Cinzia Cancellieri, Alessandro Vacchini, Massimo Locati, Raffaella Bonecchi, Elena M Borroni

Biochem Soc Trans· February 2013

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