Publications by authors named "Alex Chacko"

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Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction.
Zoey J Surma, Volodymyr Hiiuk, Eugene Zviagin, Yaxin Ouyang, Alex Chacko

Angew Chem Int Ed Engl· November 2025

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BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma.
Sara Busacca, Alex D Chacko, Astero Klabatsa, Kenneth Arthur, Michael Sheaff

PLoS One· January 2014

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Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs.
Alex D Chacko, Simon S McDade, Severine Chanduloy, Stewart W Church, Richard Kennedy

Cell Oncol (Dordr)· April 2012

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Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis.
Nyree Crawford, Alex D Chacko, Kienan I Savage, Francis McCoy, Kelly Redmond

Apoptosis· March 2011

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Voltage dependent anion channel-1 regulates death receptor mediated apoptosis by enabling cleavage of caspase-8.
Alex D Chacko, Fabio Liberante, Ian Paul, Daniel B Longley, Dean A Fennell

BMC Cancer· July 2010

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Machine vision based stochastic analysis of cancer cell mitochondrial dysfunction induced by a BH3 domain.
Alex D Chacko, Nyree T Crawford, Patrick G Johnston, Dean A Fennell

Apoptosis· November 2008

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Dynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.
Claire Grills, Nyree Crawford, Alex Chacko, Patrick G Johnston, Francesca O'Rourke

PLoS One· August 2008

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Exploiting BH3 only protein function for effective cancer therapy.
Dean A Fennell, Alex Chacko

Front Biosci· May 2008

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SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity.
Alex D Chacko, Paula L Hyland, Simon S McDade, Peter W Hamilton, Se Hilary Russell

J Pathol· August 2005

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