Publications by authors named "Alexander Birkmann"

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Refractory and Resistant Herpes Simplex Virus Mucocutaneous Infections in Immunocompromised Patients: Literature Review and Proposed Definitions for Use in Clinical Trials.
Roy F Chemaly, Tali Shafat, Anna Wald, Camille N Kotton, Genovefa Papanicolaou, Alexander Birkmann

Clin Infect Dis· October 2025

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Successful treatment and secondary prophylaxis with pritelivir for a recurrent multidrug-resistant herpes simplex virus 1 infection in an allogeneic haematopoietic stem cell transplant recipient.
Linda Bussini, A M Federica Giardina, Stefania Paolucci, Daniele Mannina, Alexander Birkmann

Clin Microbiol Infect· July 2025

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Overview on the management of herpes simplex virus infections: Current therapies and future directions.
Alexander Birkmann, Rob Saunders

Antiviral Res· May 2025

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Discovery of AIC263282, a Hepatitis B Virus Capsid Assembly Modulator Ready for Candidate Profiling.
Bernhard Lesch, Alexander Birkmann, Susanne Bonsmann, Alastair Donald, Florian Engel

J Med Chem· March 2025

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Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Pritelivir and Its Metabolites.
Katharina Erb-Zohar, Susanne Bonsmann, Jörg Pausch, Melanie Sumner, Alexander Birkmann

Clin Pharmacol Drug Dev· November 2024

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Evaluation of the Clinical Drug-Drug Interaction Potential of Pritelivir on Transporters and CYP450 Enzymes Using a Cocktail Approach.
Michiel de Vries, Susanne Bonsmann, Jörg Pausch, Melanie Sumner, Alexander Birkmann

Clin Pharmacol Drug Dev· July 2024

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TLR9-Dependent Activation by Inactivated Parapoxvirus Ovis in Murine Bone Marrow-Derived Dendritic Cells Is Associated with Specific Strain-Dependent Dendritic Cell Subsets.
Yanqin Du, Hang Sun, Sonakshi Bhattacharjee, Alexander Birkmann, Ulf Dittmer

J Innate Immun· July 2024

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Mass Balance and Metabolite Profile after Single and Multiple Oral Doses of Pritelivir in Healthy Subjects.
Susanne Bonsmann, David McCormick, Jörg Pausch, Michiel de Vries, Melanie Sumner, Alexander Birkmann

Clin Pharmacol Drug Dev· April 2024

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First-in-Human, Single- and Multiple-Ascending-Dose, Food-Effect, and Absolute Bioavailability Trials to Assess the Pharmacokinetics, Safety, and Tolerability of Pritelivir, a Nonnucleoside Helicase-Primase Inhibitor Against Herpes Simplex Virus in Healthy Subjects.
Dirk Kropeit, Susanne Bonsmann, Oliver von Richter, David McCormick, Jörg Pausch, Alexander Birkmann

Clin Pharmacol Drug Dev· July 2023

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Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections.
Alexander Birkmann, Susanne Bonsmann, Dirk Kropeit, Tamara Pfaff, Manickam Rangaraju

J Med Chem· October 2022

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Novel non-heteroarylpyrimidine (HAP) capsid assembly modifiers have a different mode of action from HAPs in vitro.
Angelica Corcuera, Katharina Stolle, Stefan Hillmer, Stefan Seitz, Ji-Young Lee, Alexander Birkmann

Antiviral Res· October 2018

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Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.
Debra C Quenelle, Alexander Birkmann, Thomas Goldner, Tamara Pfaff, Holger Zimmermann

Antiviral Res· January 2018

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Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.
Fabrizio Carta, Alexander Birkmann, Tamara Pfaff, Helmut Buschmann, Wilfried Schwab

J Med Chem· April 2017

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Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences: A Randomized Clinical Trial.
Anna Wald, Burkhard Timmler, Amalia Magaret, Terri Warren, Stephen Tyring, Alexander Birkmann

JAMA· December 2016

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No Evidence of Pritelivir Resistance Among Herpes Simplex Virus Type 2 Isolates After 4 Weeks of Daily Therapy.
Paul T Edlefsen, Alexander Birkmann, Meei-Li Huang, Craig A Magaret, Jia Jin Kee

J Infect Dis· July 2016

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HSV antivirals - current and future treatment options.
Alexander Birkmann, Holger Zimmermann

Curr Opin Virol· June 2016

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Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes.
Joshua T Schiffer, David A Swan, Amalia Magaret, Lawrence Corey, Anna Wald, Alexander Birkmann

Sci Transl Med· February 2016

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Pharmacokinetics-pharmacodynamics of the helicase-primase inhibitor pritelivir following treatment of wild-type or pritelivir-resistant virus infection in a murine herpes simplex virus 1 infection model.
Subhajit Biswas, Soumi Sukla, Thomas Goldner, Hugh J Field, Dirk Kropeit, Alexander Birkmann

Antimicrob Agents Chemother· July 2014

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Helicase-primase inhibitor pritelivir for HSV-2 infection.
Anna Wald, Lawrence Corey, Burkhard Timmler, Amalia Magaret, Terri Warren, Alexander Birkmann

N Engl J Med· January 2014

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Baseline sensitivity of HSV-1 and HSV-2 clinical isolates and defined acyclovir-resistant strains to the helicase-primase inhibitor pritelivir.
Hugh J Field, Meei-Li Huang, Elizabeth M Lay, Ian Mickleburgh, Holger Zimmermann, Alexander Birkmann

Antiviral Res· November 2013

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Effects of therapy using a helicase-primase inhibitor (HPI) in mice infected with deliberate mixtures of wild-type HSV-1 and an HPI-resistant UL5 mutant.
Soumi Sukla, Subhajit Biswas, Alexander Birkmann, Peter Lischka, Helga Ruebsamen-Schaeff

Antiviral Res· July 2010

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Mismatch primer-based PCR reveals that helicase-primase inhibitor resistance mutations pre-exist in herpes simplex virus type 1 clinical isolates and are not induced during incubation with the inhibitor.
Soumi Sukla, Subhajit Biswas, Alexander Birkmann, Peter Lischka, Holger Zimmermann

J Antimicrob Chemother· July 2010

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Kaposi's sarcoma-associated herpesvirus gH/gL: glycoprotein export and interaction with cellular receptors.
Alexander Hahn, Alexander Birkmann, Effi Wies, Dominik Dorer, Kerstin Mahr

J Virol· January 2009

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Mutations close to functional motif IV in HSV-1 UL5 helicase that confer resistance to HSV helicase-primase inhibitors, variously affect virus growth rate and pathogenicity.
Subhajit Biswas, Laurence S Tiley, Holger Zimmermann, Alexander Birkmann, Hugh J Field

Antiviral Res· October 2008

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