Publications by authors named "Alexander M Frankell"

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Longitudinal ultrasensitive ctDNA monitoring for high-resolution lung cancer risk prediction.
James R M Black, Takahiro Karasaki, Charles W Abbott, Bailiang Li, Selvaraju Veeriah, Alexander M Frankell

Cell· December 2025

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Clone copy number diversity is linked to survival in lung cancer.
Piotr Pawlik, Kristiana Grigoriadis, Abigail Bunkum, Helena Coggan, Alexander M Frankell

Nature· October 2025

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DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
Francisco Gimeno-Valiente, Carla Castignani, Elizabeth Larose Cadieux, Nana E Mensah, Xiaohong Liu, Alexander M Frankell

Nat Genet· September 2025

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A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer.
Gary Middleton, Helen L Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Alexander M Frankell

NPJ Precis Oncol· March 2025

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Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER.
Olivia Lucas, Sophia Ward, Rija Zaidi, Abigail Bunkum, Alexander M Frankell

Nat Genet· January 2025

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Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Dhruva Biswas, Yun-Hsin Liu, Javier Herrero, Yin Wu, David A Moore, Alexander M Frankell

Nat Cancer· January 2025

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Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma.
James R M Black, Gabor Bartha, Charles W Abbott, Sean M Boyle, Takahiro Karasaki, Alexander M Frankell

Nat Med· January 2025

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Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx.
Alexander M Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L Lim, Takahiro Karasaki

Nature· July 2024

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Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell

Nat Commun· June 2024

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CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction.
Kristiana Grigoriadis, Ariana Huebner, Abigail Bunkum, Emma Colliver, Alexander M Frankell

Nat Protoc· January 2024

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Clonal Evolution in Healthy and Premalignant Tissues: Implications for Early Cancer Interception Strategies.
Jayant K Rane, Alexander M Frankell, Clare E Weeden, Charles Swanton

Cancer Prev Res (Phila)· July 2023

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Evolutionary characterization of lung adenocarcinoma morphology in TRACERx.
Takahiro Karasaki, David A Moore, Selvaraju Veeriah, Cristina Naceur-Lombardelli, Antonia Toncheva, Alexander M Frankell

Nat Med· April 2023

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Body composition and lung cancer-associated cachexia in TRACERx.
Othman Al-Sawaf, Jakob Weiss, Marcin Skrzypski, Jie Min Lam, Takahiro Karasaki, Alexander M Frankell

Nat Med· April 2023

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Genomic-transcriptomic evolution in lung cancer and metastasis.
Carlos Martínez-Ruiz, James R M Black, Clare Puttick, Mark S Hill, Jonas Demeulemeester, Alexander M Frankell

Nature· April 2023

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Antibodies against endogenous retroviruses promote lung cancer immunotherapy.
Kevin W Ng, Jesse Boumelha, Katey S S Enfield, Jorge Almagro, Hongui Cha, Alexander M Frankell

Nature· April 2023

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The evolution of non-small cell lung cancer metastases in TRACERx.
Maise Al Bakir, Ariana Huebner, Carlos Martínez-Ruiz, Kristiana Grigoriadis, Thomas B K Watkins, Alexander M Frankell

Nature· April 2023

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The evolution of lung cancer and impact of subclonal selection in TRACERx.
Alexander M Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L Lim, Takahiro Karasaki

Nature· April 2023

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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
Christopher Abbosh, Alexander M Frankell, Thomas Harrison, Judit Kisistok, Aaron Garnett

Nature· April 2023

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ctDNA in Gastric and Gastroesophageal Cancer: Prognostic, Predictive, or Preliminary?
Alexander M Frankell, Elizabeth C Smyth

Clin Cancer Res· December 2019

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The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic.
Alexander M Frankell, SriGanesh Jammula, Xiaodun Li, Gianmarco Contino, Sarah Killcoyne

Nat Genet· March 2019

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