Publications by authors named "Alexander Shoemaker"

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Corrigendum to "Investigation of biaryl heterocycles as inhibitors of Wee1 kinase" [Bioorg. Med. Chem. Lett. 29 (2019) 1481-1486].
Anthony Mastracchio, Chunqiu Lai, Maricel Torrent, Kenneth Bromberg, Fritz G Buchanan, Alexander R Shoemaker

Bioorg Med Chem Lett· February 2020

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Investigation of biaryl heterocycles as inhibitors of Wee1 kinase.
Anthony Mastracchio, Chunqiu Lai, Maricel Torrent, Kenneth Bromberg, Fritz G Buchanan, Alexander R Shoemaker

Bioorg Med Chem Lett· June 2019

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Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
Clarissa G Jakob, Anup K Upadhyay, Pamela L Donner, Emily Nicholl, Sadiya N Addo, Alexander R Shoemaker

J Med Chem· August 2018

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The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.
William N Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Alexander R Shoemaker

PLoS One· April 2016

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Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase.
Yunsong Tong, Maricel Torrent, Alan S Florjancic, Kenneth D Bromberg, Fritz G Buchanan, Alexander R Shoemaker

ACS Med Chem Lett· January 2015

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Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195.
Yunsong Tong, Kent D Stewart, Alan S Florjancic, John E Harlan, Philip J Merta, Alexander R Shoemaker

ACS Med Chem Lett· February 2013

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Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.
Qingwei Zhang, Zhiren Xia, Michael J Mitten, Loren M Lasko, Vered Klinghofer, Alexander R Shoemaker

Bioorg Med Chem Lett· December 2012

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Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.
Gui-Dong Zhu, Jianchun Gong, Viraj B Gandhi, Xuesong Liu, Yan Shi, Alexander Shoemaker

Bioorg Med Chem· August 2012

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Aminopyrimidinone cdc7 kinase inhibitors.
Keith W Woods, Chunqiu Lai, Julie M Miyashiro, Yunsong Tong, Alan S Florjancic, Alexander R Shoemaker

Bioorg Med Chem Lett· March 2012

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Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor.
Xuesong Liu, Yan Shi, David X Maag, Joann P Palma, Melanie J Patterson, Alexander R Shoemaker

Clin Cancer Res· January 2012

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The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo.
Jun Chen, Sha Jin, Vivek Abraham, Xiaoli Huang, Bernard Liu, Alexander R Shoemaker

Mol Cancer Ther· December 2011

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Ubiquitin-specific cysteine protease 2a (USP2a) regulates the stability of Aurora-A.
Yan Shi, Larry R Solomon, Ana Pereda-Lopez, Vincent L Giranda, Yan Luo, Alexander R Shoemaker

J Biol Chem· November 2011

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The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo.
Scott Ackler, Michael J Mitten, Kelly Foster, Anatol Oleksijew, Marion Refici, Alexander R Shoemaker

Cancer Chemother Pharmacol· October 2010

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Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.
Xuesong Liu, Edward K Han, Mark Anderson, Yan Shi, Dimitri Semizarov, Alexander R Shoemaker

Mol Cancer Res· October 2009

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Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins.
Cheol-Min Park, Milan Bruncko, Jessica Adickes, Joy Bauch, Hong Ding, Alexander R Shoemaker

J Med Chem· November 2008

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.
Christin Tse, Alexander R Shoemaker, Jessica Adickes, Mark G Anderson, Jun Chen

Cancer Res· May 2008

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Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
Milan Bruncko, Thorsten K Oost, Barbara A Belli, Hong Ding, Mary K Joseph, Alexander R Shoemaker

J Med Chem· February 2007

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Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers.
Gui-Dong Zhu, Viraj B Gandhi, Jianchun Gong, Yan Luo, Xuesong Liu, Alexander Shoemaker

Bioorg Med Chem Lett· July 2006

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Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity.
Gui-Dong Zhu, Jianchun Gong, Akiyo Claiborne, Keith W Woods, Viraj B Gandhi, Alexander Shoemaker

Bioorg Med Chem Lett· June 2006

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Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
Michael D Wendt, Wang Shen, Aaron Kunzer, William J McClellan, Milan Bruncko, Alexander R Shoemaker

J Med Chem· February 2006

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Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivo.
Yan Shi, Xuesong Liu, Edward K Han, Ran Guan, Alexander R Shoemaker

Neoplasia· November 2005

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Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.
Leiming Li, Xiaoyu Lin, Michael Staver, Alexander Shoemaker, Dimitri Semizarov

Cancer Res· August 2005

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Tilman Oltersdorf, Steven W Elmore, Alexander R Shoemaker, Robert C Armstrong, David J Augeri

Nature· June 2005

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Yan Luo, Alexander R Shoemaker, Xuesong Liu, Keith W Woods, Sheela A Thomas

Mol Cancer Ther· June 2005

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Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth.
Xuesong Liu, Jessica Powlas, Yan Shi, Anatol X Oleksijew, Alexander R Shoemaker

Anticancer Res· December 2004

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