Publications by authors named "Alexander Straub"

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Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution.
Chantal Fürstner, Jens Ackerstaff, Heinrich Meier, Alexander Straub, Joachim Mittendorf

J Med Chem· March 2025

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Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance.
Alexandros Vakalopoulos, Daniel Basting, Markus Brechmann, Henrik Teller, Melissa Boultadakis Arapinis, Alexander Straub

J Med Chem· November 2024

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Visual Analysis of Displacement Processes in Porous Media using Spatio-Temporal Flow Graphs.
Alexander Straub, Nikolaos Karadimitriou, Guido Reina, Steffen Frey, Holger Steeb

IEEE Trans Vis Comput Graph· January 2024

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New Generation of sGC Stimulators: Discovery of Imidazo[1,2-]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension.
Alexandros Vakalopoulos, Frank Wunder, Ingo V Hartung, Gorden Redlich, Rolf Jautelat, Alexander Straub

J Med Chem· June 2023

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BAY-6096: A Potent, Selective, and Highly Water-Soluble Adrenergic α Antagonist.
Daniel Meibom, Jutta Meyer, Clemens-Jeremias von Buehler, Karl D Collins, Stefanie Maassen, Alexander Straub

J Med Chem· April 2023

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2019 IEEE Scientific Visualization Contest Winner: Visual Analysis of Structure Formation in Cosmic Evolution.
Karsten Schatz, Christoph Muller, Patrick Gralka, Moritz Heinemann, Alexander Straub

IEEE Comput Graph Appl· December 2021

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Altered adipokines in obese adolescents: a cross-sectional and longitudinal analysis across the spectrum of glycemia.
Risa M Wolf, Andrew E Jaffe, Susana Rodriguez, Xia Lei, Dylan C Sarver, Alexander T Straub

Am J Physiol Endocrinol Metab· June 2021

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"CHicable" and "Clickable" Copolymers for Network Formation and Surface Modification.
Alexander J Straub, Frank D Scherag, Hye In Kim, Mark-Steven Steiner, Thomas Brandstetter

Langmuir· June 2021

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Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.
Markus Follmann, Jens Ackerstaff, Gorden Redlich, Frank Wunder, Dieter Lang, Alexander Straub

J Med Chem· June 2017

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Submicron Patterning of Polymer Brushes: An Unexpected Discovery from Inkjet Printing of Polyelectrolyte Macroinitiators.
Adam V S Parry, Alexander J Straub, Eva M Villar-Alvarez, Takdanai Phuengphol, Jonathan E R Nicoll

J Am Chem Soc· July 2016

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The chemistry and biology of soluble guanylate cyclase stimulators and activators.
Markus Follmann, Nils Griebenow, Michael G Hahn, Ingo Hartung, Franz-Josef Mais, Alexander Straub

Angew Chem Int Ed Engl· September 2013

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Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators.
Nils Griebenow, Hartmut Schirok, Joachim Mittendorf, Alexander Straub, Markus Follmann

Bioorg Med Chem Lett· March 2013

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Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines?
Alexander Straub, Susanne Roehrig, Alexander Hillisch

Angew Chem Int Ed Engl· May 2011

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The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor.
Elisabeth Perzborn, Susanne Roehrig, Alexander Straub, Dagmar Kubitza, Frank Misselwitz

Nat Rev Drug Discov· January 2011

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Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban).
Alexander Straub, Susanne Roehrig, Alexander Hillisch

Curr Top Med Chem· September 2010

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Rivaroxaban: a new oral factor Xa inhibitor.
Elisabeth Perzborn, Susanne Roehrig, Alexander Straub, Dagmar Kubitza, Wolfgang Mueck

Arterioscler Thromb Vasc Biol· March 2010

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Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.
Joachim Mittendorf, Stefan Weigand, Cristina Alonso-Alija, Erwin Bischoff, Achim Feurer, Alexander Straub

ChemMedChem· May 2009

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Discovery of the novel antithrombotic agent 5-chloro-N-({(5S)-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939): an oral, direct factor Xa inhibitor.
Susanne Roehrig, Alexander Straub, Jens Pohlmann, Thomas Lampe, Josef Pernerstorfer

J Med Chem· September 2005

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Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.
Alexander Straub, Jordi Benet-Buckholz, Rita Fröde, Armin Kern, Christian Kohlsdorfer

Bioorg Med Chem· June 2002

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Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.
Johannes-Peter Stasch, Cristina Alonso-Alija, Heiner Apeler, Klaus Dembowsky, Achim Feurer, Alexander Straub

Br J Pharmacol· January 2002

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