Publications by authors named "Alexandra Hinniger"

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Development of a p62 biodegrader for autophagy targeted degradation.
Zacharias Thiel, David Marcellin, Carole Manneville, Benedikt Goretzki, Luca Egger, Alexandra Hinniger

Nat Commun· December 2025

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Discovery and Characterization of Zilurgisertib, a Potent and Selective Inhibitor of Activin Receptor-like Kinase‑2 (ALK2) for the Treatment of Fibrodysplasia Ossificans Progressiva.
Thomas Ullrich, Sabine Guth, Luca Arista, Sven Weiler, Nikolaus Stiefl, Alexandra Hinniger

ACS Med Chem Lett· November 2025

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Correction to "Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome Inhibitor".
Dong-Ming Shen, Kate F Byth, Damien Bertheloot, Simona Braams, Sarah Bradley, Alexandra Hinniger

J Med Chem· April 2025

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Discovery of DFV890, a Potent Sulfonimidamide-Containing NLRP3 Inflammasome Inhibitor.
Dong-Ming Shen, Kate F Byth, Damien Bertheloot, Simona Braams, Sarah Bradley, Alexandra Hinniger

J Med Chem· March 2025

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Discovery of NP3-253, a Potent Brain Penetrant Inhibitor of the NLRP3 Inflammasome.
Angela Mackay, Juraj Velcicky, Nina Gommermann, Henri Mattes, Philipp Janser, Alexandra Hinniger

J Med Chem· December 2024

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Dual BACH1 regulation by complementary SCF-type E3 ligases.
Benedikt Goretzki, Maryam Khoshouei, Martin Schröder, Patrick Penner, Luca Egger, Alexandra Hinniger

Cell· December 2024

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Discovery of Potent, Orally Bioavailable, Tricyclic NLRP3 Inhibitors.
Juraj Velcicky, Philipp Janser, Nina Gommermann, Silke Brenneisen, Slavica Ilic, Alexandra Hinniger

J Med Chem· January 2024

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Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.
Carien Dekker, Henri Mattes, Michael Wright, Andreas Boettcher, Alexandra Hinniger

J Mol Biol· December 2021

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PAX8 and MECOM are interaction partners driving ovarian cancer.
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Alexandra Hinniger

Nat Commun· April 2021

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Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Daniela Angst, François Gessier, Philipp Janser, Anna Vulpetti, Rudolf Wälchli, Alexandra Hinniger

J Med Chem· May 2020

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Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.
Robert Pulz, Daniela Angst, Janet Dawson, Francois Gessier, Sascha Gutmann, Alexandra Hinniger

ACS Med Chem Lett· October 2019

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Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM.
Nina Ripin, Julien Boudet, Malgorzata M Duszczyk, Alexandra Hinniger, Michael Faller

Proc Natl Acad Sci U S A· February 2019

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Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Nathalie Bürstner, Silvio Roggo, Nils Ostermann, Jutta Blank, Cecile Delmas, Alexandra Hinniger

Chembiochem· November 2015

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The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
Sascha Gutmann, Alexandra Hinniger, Gabriele Fendrich, Peter Drückes, Sylvie Antz

J Biol Chem· June 2015

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A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility.
Alvar D Gossert, Alexandra Hinniger, Sascha Gutmann, Wolfgang Jahnke, André Strauss

J Biomol NMR· December 2011

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