Publications by authors named "Sascha Gutmann"

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Development of a p62 biodegrader for autophagy targeted degradation.
Zacharias Thiel, David Marcellin, Carole Manneville, Benedikt Goretzki, Luca Egger, Sascha Gutmann

Nat Commun· December 2025

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Dual BACH1 regulation by complementary SCF-type E3 ligases.
Benedikt Goretzki, Maryam Khoshouei, Martin Schröder, Patrick Penner, Luca Egger, Sascha Gutmann

Cell· December 2024

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Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.
Robin A Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Sascha Gutmann

J Med Chem· June 2022

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PAX8 and MECOM are interaction partners driving ovarian cancer.
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Sascha Gutmann

Nat Commun· April 2021

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Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Daniela Angst, François Gessier, Philipp Janser, Anna Vulpetti, Rudolf Wälchli, Sascha Gutmann

J Med Chem· May 2020

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Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation.
Robert Pulz, Daniela Angst, Janet Dawson, Francois Gessier, Sascha Gutmann

ACS Med Chem Lett· October 2019

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Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Zécri, Ross S Strang, Nadege Graveleau, Sascha Gutmann

ACS Med Chem Lett· September 2017

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Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors.
Ralf Glatthar, Aleksandar Stojanovic, Thomas Troxler, Henri Mattes, Henrik Möbitz, Sascha Gutmann

J Med Chem· August 2016

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Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Stauffer, Pascal Furet, Nadege Graveleau, Sascha Gutmann

ACS Med Chem Lett· August 2016

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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.
Alexei S Karpov, Payman Amiri, Cornelia Bellamacina, Marie-Helene Bellance, Werner Breitenstein, Sascha Gutmann

ACS Med Chem Lett· July 2015

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The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold.
Sascha Gutmann, Alexandra Hinniger, Gabriele Fendrich, Peter Drückes, Sylvie Antz

J Biol Chem· June 2015

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BMX and its role in inflammation, cardiovascular disease, and cancer.
Bruno Cenni, Sascha Gutmann, Marie Gottar-Guillier

Int Rev Immunol· April 2012

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A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility.
Alvar D Gossert, Alexandra Hinniger, Sascha Gutmann, Wolfgang Jahnke, André Strauss

J Biomol NMR· December 2011

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Origin and temperature dependence of radiation damage in biological samples at cryogenic temperatures.
Alke Meents, Sascha Gutmann, Armin Wagner, Clemens Schulze-Briese

Proc Natl Acad Sci U S A· January 2010

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The atomic structure of baculovirus polyhedra reveals the independent emergence of infectious crystals in DNA and RNA viruses.
Fasséli Coulibaly, Elaine Chiu, Sascha Gutmann, Chitra Rajendran, Peter W Haebel

Proc Natl Acad Sci U S A· December 2009

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A new aspect of specific radiation damage: hydrogen abstraction from organic molecules.
Alke Meents, Birger Dittrich, Sascha Gutmann

J Synchrotron Radiat· March 2009

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Structural basis of enzyme encapsulation into a bacterial nanocompartment.
Markus Sutter, Daniel Boehringer, Sascha Gutmann, Susanne Günther, David Prangishvili

Nat Struct Mol Biol· September 2008

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The molecular organization of cypovirus polyhedra.
Fasséli Coulibaly, Elaine Chiu, Keiko Ikeda, Sascha Gutmann, Peter W Haebel

Nature· March 2007

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Dial tm for rescue: tmRNA engages ribosomes stalled on defective mRNAs.
Peter W Haebel, Sascha Gutmann, Nenad Ban

Curr Opin Struct Biol· February 2004

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Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB.
Sascha Gutmann, Peter W Haebel, Laurent Metzinger, Markus Sutter, Brice Felden

Nature· August 2003

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