Publications by authors named "Frederic Zecri"

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Selectivity Profiling of Bromodomain PROTACs Using Chemical Inducers of Proximity DNA-Encoded Library Screening.
Yuen Ting Chow, Bingqi Tong, Zher Yin Tan, Antonin Tutter, Zhihan Nan

ACS Chem Biol· September 2025

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Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras.
Charles W Parry, Francesca Pellicano, Alexander W Schüttelkopf, Kim S Beyer, Justin Bower, Frederic Zecri

J Med Chem· May 2025

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Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator.
Zher Yin Tan, Joel K A Adade, Xiebin Gu, Cody J S Hecht, Michael Salcius

Cell Chem Biol· March 2025

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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers.
Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler, Rita Andraos-Rey

Nature· May 2024

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DNA-encoded library-enabled discovery of proximity-inducing small molecules.
Jeremy W Mason, Yuen Ting Chow, Liam Hudson, Antonin Tutter, Gregory Michaud

Nat Chem Biol· February 2024

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Author Correction: Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Liam Hudson, Jeremy W Mason, Matthias V Westphal, Matthieu J R Richter, Jonathan R Thielman

Nat Commun· November 2023

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Rational Screening for Cooperativity in Small-Molecule Inducers of Protein-Protein Associations.
Shuang Liu, Bingqi Tong, Jeremy W Mason, Jonathan M Ostrem, Antonin Tutter

J Am Chem Soc· October 2023

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Diversity-oriented synthesis encoded by deoxyoligonucleotides.
Liam Hudson, Jeremy W Mason, Matthias V Westphal, Matthieu J R Richter, Jonathan R Thielman

Nat Commun· August 2023

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Rational screening for cooperativity in small-molecule inducers of protein-protein associations.
Shuang Liu, Bingqi Tong, Jeremy W Mason, Jonathan M Ostrem, Antonin Tutter

bioRxiv· May 2023

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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Simone Bonazzi, Eva d'Hennezel, Rohan E J Beckwith, Lei Xu, Aleem Fazal

Cell Chem Biol· March 2023

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS for the Treatment of Solid Tumors.
Edwige Lorthiois, Marc Gerspacher, Kim S Beyer, Andrea Vaupel, Catherine Leblanc, Frederic J Zecri

J Med Chem· December 2022

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Modular Synthesis of Cyclopropane-Fused N-Heterocycles Enabled by Underexplored Diazo Reagents.
Matthieu J R Richter, Frédéric J Zécri, Karin Briner, Stuart L Schreiber

Angew Chem Int Ed Engl· September 2022

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S Beyer, Claudio Bomio-Confaglia, Frederic Zecri

Cancer Discov· June 2022

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A Phenotypic Screen Identifies Calcium Overload as a Key Mechanism of β-Cell Glucolipotoxicity.
Jennifer Vogel, Jianning Yin, Liansheng Su, Sharon X Wang, Richard Zessis, Frederic Zecri

Diabetes· May 2020

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Water-Compatible Cycloadditions of Oligonucleotide-Conjugated Strained Allenes for DNA-Encoded Library Synthesis.
Matthias V Westphal, Liam Hudson, Jeremy W Mason, Johan A Pradeilles, Frédéric J Zécri

J Am Chem Soc· April 2020

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Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor.
Tyler J Harrison, Daniel Bauer, Alina Berdichevsky, Xin Chen, Rohit Duvadie, Frederic Zecri

ACS Med Chem Lett· August 2019

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3'-Modification stabilizes mRNA and increases translation in cells.
Christian Gampe, Amy C Seila White, Swetha Siva, Frédéric Zécri, John Diener

Bioorg Med Chem Lett· August 2018

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Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Zécri, Ross S Strang, Nadege Graveleau

ACS Med Chem Lett· September 2017

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Predictive Model for Site-Selective Aryl and Heteroaryl C-H Functionalization via Organic Photoredox Catalysis.
Kaila A Margrey, Joshua B McManus, Simone Bonazzi, Frederic Zecri, David A Nicewicz

J Am Chem Soc· August 2017

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Medicinal Chemistry Profiling of Monocyclic 1,2-Azaborines.
Peng Zhao, David O Nettleton, Rajeshri G Karki, Frédéric J Zécri, Shih-Yuan Liu

ChemMedChem· March 2017

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Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties.
Klemens Hoegenauer, Nicolas Soldermann, Christina Hebach, Gregory J Hollingworth, Ian Lewis

Bioorg Med Chem Lett· December 2016

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Covalent Chemical 5'-Functionalization of RNA with Diazo Reagents.
Christian M Gampe, Micah Hollis-Symynkywicz, Frédéric Zécri

Angew Chem Int Ed Engl· August 2016

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Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
Klemens Hoegenauer, Nicolas Soldermann, Frédéric Stauffer, Pascal Furet, Nadege Graveleau

ACS Med Chem Lett· August 2016

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From Natural Product to the First Oral Treatment for Multiple Sclerosis: The Discovery of FTY720 (Gilenya™)?
Frédéric J Zécri

Curr Opin Chem Biol· June 2016

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The design and implementation of a generic lipopeptide scanning platform to enable the identification of 'locally acting' agonists for the apelin receptor.
Stephen C McKeown, Frederic J Zecri, Eric Fortier, Andrew Taggart, Lilya Sviridenko

Bioorg Med Chem Lett· October 2014

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