Publications by authors named "Tyler J Harrison"

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Phototoxicity─Medicinal Chemistry Strategies for Risk Mitigation in Drug Discovery.
Tyler J Harrison, Xin Chen, Kayo Yasoshima, Daniel Bauer

J Med Chem· July 2023

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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Jean B Regard, Tyler J Harrison, Jake Axford, Laura Axford, Lac Lee

Biochem Pharmacol· March 2023

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Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Anup Patnaik, Laura Axford, Lin Deng, Evan Cohick, Xianglin Ren, Tyler J Harrison

Bioorg Med Chem· June 2020

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Successful Strategies for Mitigation of a Preclinical Signal for Phototoxicity in a DGAT1 Inhibitor.
Tyler J Harrison, Daniel Bauer, Alina Berdichevsky, Xin Chen, Rohit Duvadie

ACS Med Chem Lett· August 2019

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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
Martin L Marro, Andrew W Patterson, Lac Lee, Lin Deng, Aimee Reynolds, Tyler J Harrison

J Pharmacol Exp Ther· October 2018

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High and dry? Comparing active dry EEG electrodes to active and passive wet electrodes.
Kyle E Mathewson, Tyler J L Harrison, Sayeed A D Kizuk

Psychophysiology· January 2017

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Consecutively reconstructing absorption and scattering distributions in turbid media with multiple-illumination photoacoustic tomography.
Peng Shao, Tyler J Harrison, Roger J Zemp

J Biomed Opt· December 2014

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An "aprotic" Tamao oxidation/syn-selective tautomerization reaction for the efficient synthesis of the C1-C9 fragment of fludelone.
Tyler J Harrison, Philippe M A Rabbat, James L Leighton

Org Lett· September 2012

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Toward more "ideal" polyketide natural product synthesis: a step-economical synthesis of zincophorin methyl ester.
Tyler J Harrison, Stephen Ho, James L Leighton

J Am Chem Soc· May 2011

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Enamides and enesulfonamides as nucleophiles: formation of complex ring systems through a platinum(II)-catalyzed addition/Friedel-Crafts pathway.
Jennifer A Kozak, Jennifer M Dodd, Tyler J Harrison, Katherine J Jardine, Brian O Patrick

J Org Chem· September 2009

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Platinum(II)-catalyzed cyclizations forming quaternary carbon centers, using enesulfonamides, enecarbamates, or enamides as nucleophiles.
Tyler J Harrison, Brian O Patrick, Gregory R Dake

Org Lett· January 2007

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Pyrrole synthesis catalyzed by AgOTf or cationic Au(I) complexes.
Tyler J Harrison, Jennifer A Kozak, Montserrat Corbella-Pané, Gregory R Dake

J Org Chem· June 2006

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An expeditious, high-yielding construction of the food aroma compounds 6-acetyl-1,2,3,4-tetrahydropyridine and 2-acetyl-1-pyrroline.
Tyler J Harrison, Gregory R Dake

J Org Chem· December 2005

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Pt(II) or Ag(I) salt catalyzed cycloisomerizations and tandem cycloadditions forming functionalized azacyclic arrays.
Tyler J Harrison, Gregory R Dake

Org Lett· December 2004

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A modular and concise total synthesis of (+/-)-daurichromenic acid and analogues.
Hongjuan Hu, Tyler J Harrison, Peter D Wilson

J Org Chem· May 2004

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