Publications by authors named "Lac Lee"

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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Jean B Regard, Tyler J Harrison, Jake Axford, Laura Axford, Lac Lee

Biochem Pharmacol· March 2023

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Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Anup Patnaik, Laura Axford, Lin Deng, Evan Cohick, Xianglin Ren, Lac Lee

Bioorg Med Chem· June 2020

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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
Martin L Marro, Andrew W Patterson, Lac Lee, Lin Deng, Aimee Reynolds

J Pharmacol Exp Ther· October 2018

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.
Frederic Bassilana, Adam Carlson, Jennifer A DaSilva, Bianka Grosshans, Solange Vidal, Lac Lee

Nat Chem Biol· May 2014

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Discovery of LFF571: an investigational agent for Clostridium difficile infection.
Matthew J LaMarche, Jennifer A Leeds, Adam Amaral, Jason T Brewer, Simon M Bushell, Kwangho Lee, Lac Lee

J Med Chem· March 2012

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Biophysical investigation of the mode of inhibition of tetramic acids, the allosteric inhibitors of undecaprenyl pyrophosphate synthase.
Lac V Lee, Brian Granda, Karl Dean, Jianshi Tao, Eugene Liu

Biochemistry· June 2010

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Multiple cyclophilins involved in different cellular pathways mediate HCV replication.
L Alex Gaither, Jason Borawski, Leah J Anderson, Kara A Balabanis, Piroska Devay, Lac Lee

Virology· February 2010

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Isotope effects on the enzymatic and nonenzymatic reactions of chorismate.
S Kirk Wright, Michael S DeClue, Ajay Mandal, Lac Lee, Olaf Wiest

J Am Chem Soc· September 2005

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Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet-Spengler reaction followed by screening in situ.
Mehdi M D Numa, Lac V Lee, Che-Chang Hsu, Kristen E Bower, Chi-Huey Wong

Chembiochem· June 2005

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Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor.
Micha Fridman, Valery Belakhov, Lac V Lee, Fu-Sen Liang, Chi-Huey Wong

Angew Chem Int Ed Engl· January 2005

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In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II.
Vani P Mocharla, Benoit Colasson, Lac V Lee, Stefanie Röper, K Barry Sharpless

Angew Chem Int Ed Engl· December 2004

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High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays.
Marian C Bryan, Lac V Lee, Chi-Huey Wong

Bioorg Med Chem Lett· June 2004

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Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening.
Michael D Best, Ashraf Brik, Eli Chapman, Lac V Lee, Wei-Chieh Cheng

Chembiochem· June 2004

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Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides.
Lac V Lee, Kristen E Bower, Fu-Sen Liang, Jin Shi, Douglass Wu

J Am Chem Soc· April 2004

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Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expression.
Tony K-K Mong, Lac V Lee, Jillian R Brown, Jeffrey D Esko, Chi-Huey Wong

Chembiochem· September 2003

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A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry.
Lac V Lee, Michael L Mitchell, Shih-Jung Huang, Valery V Fokin, K Barry Sharpless

J Am Chem Soc· August 2003

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Synthesis and evaluation of transition-state analogue inhibitors of alpha-1,3-fucosyltransferase.
Michael L Mitchell, Feng Tian, Lac V Lee, Chi-Huey Wong

Angew Chem Int Ed Engl· August 2002

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