Publications by authors named "Andrew W Patterson"

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Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease.
John Ryan Kerrigan, Noel M Thomsen, Artiom Cernijenko, Sarah E Kochanek, Janetta Dewhurst, Andrew W Patterson

J Med Chem· November 2024

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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Pamela Y Ting, Sneha Borikar, John Ryan Kerrigan, Noel M Thomsen, Eamon Aghania, Andrew W Patterson

Science· July 2024

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Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase.
Klemens Hoegenauer, Shaojian An, Jake Axford, Christina Benander, Christian Bergsdorf, Andrew W Patterson

ACS Med Chem Lett· December 2023

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Discovery of a novel, highly potent and orally bioavailable pyrrolidinone indole series of irreversible Myeloperoxidase (MPO) inhibitors.
Jean B Regard, Tyler J Harrison, Jake Axford, Laura Axford, Lac Lee, Andrew W Patterson

Biochem Pharmacol· March 2023

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Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Anup Patnaik, Laura Axford, Lin Deng, Evan Cohick, Xianglin Ren, Andrew W Patterson

Bioorg Med Chem· June 2020

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Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor.
Martin L Marro, Andrew W Patterson, Lac Lee, Lin Deng, Aimee Reynolds

J Pharmacol Exp Ther· October 2018

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Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles.
Hasnain A Malik, Buck L H Taylor, John R Kerrigan, Jonathan E Grob, K N Houk, Andrew W Patterson

Chem Sci· June 2014

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Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice.
William C Floyd, Gopal K Datta, Shinichi Imamura, Heidi M Kieler-Ferguson, Katherine Jerger, Andrew W Patterson

ChemMedChem· January 2011

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Expedient synthesis of N-methyl tubulysin analogues with high cytotoxicity.
Andrew W Patterson, Hillary M Peltier, Jonathan A Ellman

J Org Chem· June 2008

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Design, synthesis, and biological properties of highly potent tubulysin D analogues.
Andrew W Patterson, Hillary M Peltier, Florenz Sasse, Jonathan A Ellman

Chemistry· February 2008

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Substrate activity screening (SAS): a general procedure for the preparation and screening of a fragment-based non-peptidic protease substrate library for inhibitor discovery.
Andrew W Patterson, Warren J L Wood, Jonathan A Ellman

Nat Protoc· June 2007

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The total synthesis of tubulysin D.
Hillary M Peltier, Jeffrey P McMahon, Andrew W Patterson, Jonathan A Ellman

J Am Chem Soc· December 2006

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Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method.
Andrew W Patterson, Warren J L Wood, Michael Hornsby, Scott Lesley, Glen Spraggon

J Med Chem· October 2006

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Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines.
Andrew W Patterson, Jonathan A Ellman

J Org Chem· September 2006

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Substrate activity screening: a fragment-based method for the rapid identification of nonpeptidic protease inhibitors.
Warren J L Wood, Andrew W Patterson, Hiroyuki Tsuruoka, Rishi K Jain, Jonathan A Ellman

J Am Chem Soc· November 2005

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