Publications by authors named "Alfred Chappell"

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Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew J Simon, Alfred Chappell

Sci Transl Med· August 2024

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Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor.
Carol Kuo, Mehran Nikan, Steve T Yeh, Alfred E Chappell, Michael Tanowitz

Nucleic Acid Ther· August 2022

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Mechanisms of palmitic acid-conjugated antisense oligonucleotide distribution in mice.
Alfred E Chappell, Hans J Gaus, Andres Berdeja, Ruchi Gupta, Minji Jo

Nucleic Acids Res· May 2020

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AMPK mediates inhibition of electrolyte transport and NKCC1 activity by reactive oxygen species.
Stephanie J King, Michael Bunz, Alfred Chappell, Michael Scharl, Michael Docherty

Am J Physiol Gastrointest Liver Physiol· August 2019

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Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle.
Thazha P Prakash, Adam E Mullick, Richard G Lee, Jinghua Yu, Steve T Yeh, Alfred E Chappell

Nucleic Acids Res· July 2019

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Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay.
Hans J Gaus, Ruchi Gupta, Alfred E Chappell, Michael E Østergaard, Eric E Swayze

Nucleic Acids Res· February 2019

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Identification of metabolically stable 5΄-phosphate analogs that support single-stranded siRNA activity.
Thazha P Prakash, Walt F Lima, Heather M Murray, Wenyu Li, Garth A Kinberger, Alfred E Chappell

Nucleic Acids Res· June 2017

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Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.
Garth A Kinberger, Thazha P Prakash, Jinghua Yu, Guillermo Vasquez, Audrey Low, Alfred Chappell

Bioorg Med Chem Lett· August 2016

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Synergistic effect of phosphorothioate, 5'-vinylphosphonate and GalNAc modifications for enhancing activity of synthetic siRNA.
Thazha P Prakash, Garth A Kinberger, Heather M Murray, Alfred Chappell, Stan Riney

Bioorg Med Chem Lett· June 2016

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Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.
Thazha P Prakash, Jinghua Yu, Michael T Migawa, Garth A Kinberger, W Brad Wan, Alfred Chappell

J Med Chem· March 2016

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Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.
Thazha P Prakash, W Brad Wan, Audrey Low, Jinghua Yu, Alfred E Chappell

Bioorg Med Chem Lett· October 2015

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Identification of metabolically stable 5'-phosphate analogs that support single-stranded siRNA activity.
Thazha P Prakash, Walt F Lima, Heather M Murray, Wenyu Li, Garth A Kinberger, Alfred E Chappell

Nucleic Acids Res· March 2015

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Mechanistic understanding for the greater sensitivity of monkeys to antisense oligonucleotide-mediated complement activation compared with humans.
Lijiang Shen, Ashley Frazer-Abel, Paul R Reynolds, Patricia C Giclas, Alfred Chappell

J Pharmacol Exp Ther· December 2014

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.
Thazha P Prakash, Mark J Graham, Jinghua Yu, Rick Carty, Audrey Low, Alfred Chappell

Nucleic Acids Res· July 2014

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Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals.
Thazha P Prakash, Walt F Lima, Heather M Murray, Sayda Elbashir, William Cantley, Alfred E Chappell

ACS Chem Biol· July 2013

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Single-stranded siRNAs activate RNAi in animals.
Walt F Lima, Thazha P Prakash, Heather M Murray, Garth A Kinberger, Wenyu Li, Alfred E Chappell

Cell· August 2012

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TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.
Sue Murray, Damian Ittig, Erich Koller, Andres Berdeja, Alfred Chappell

Nucleic Acids Res· July 2012

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Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes.
Erich Koller, Thomas M Vincent, Alfred Chappell, Soma De, Muthiah Manoharan

Nucleic Acids Res· June 2011

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Hydrogen peroxide inhibits Ca2+-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins.
Alfred E Chappell, Michael Bunz, Eric Smoll, Hui Dong, Christian Lytle

FASEB J· June 2008

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5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury.
Anders J Smith, Alfred E Chappell, Andre G Buret, Kim E Barrett, Hui Dong

FASEB J· December 2006

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Pharmacokinetics of a tumor necrosis factor-alpha phosphorothioate 2'-O-(2-methoxyethyl) modified antisense oligonucleotide: comparison across species.
Richard S Geary, Rosie Z Yu, Tanya Watanabe, Scott P Henry, Greg E Hardee, Alfred Chappell

Drug Metab Dispos· November 2003

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Development of an ultrasensitive noncompetitive hybridization-ligation enzyme-linked immunosorbent assay for the determination of phosphorothioate oligodeoxynucleotide in plasma.
Rosie Z Yu, Brenda Baker, Alfred Chappell, Richard S Geary, Ellen Cheung

Anal Biochem· May 2002

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Addition of bromine chloride and iodine monochloride to carbonyl-conjugated, acetylenic ketones: synthesis and mechanisms.
Victor L Heasley, Deanna M Buczala, Alfred E Chappell, David J Hill, Josh M Whisenand

J Org Chem· April 2002

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