Publications by authors named "Alice B Ke"

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Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.
Peter J Kilford, Kuan-Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke

CPT Pharmacometrics Syst Pharmacol· July 2022

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Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations.
Laura Oggianu, Giorgio Di Dato, Giorgina Mangano, Maria Teresa Rosignoli, Savannah McFeely, Alice Ban Ke

Clin Transl Sci· June 2022

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Physiologically Based Pharmacokinetic Modeling and Allometric Scaling in Pediatric Drug Development: Where Do We Draw the Line?
Trevor N Johnson, Alice B Ke

J Clin Pharmacol· June 2021

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A physiologically based pharmacokinetic - pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.
Mailys De Sousa Mendes, Oliver Hatley, Katherine Linda Gill, Karen Rowland Yeo, Alice Ban Ke

Eur J Pharm Sci· July 2020

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Estimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.
Laura Oggianu, Alice B Ke, Manoranjenni Chetty, Rossella Picollo, Vanessa Petrucci

CPT Pharmacometrics Syst Pharmacol· February 2020

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Evaluation of Maternal Drug Exposure Following the Administration of Antenatal Corticosteroids During Late Pregnancy Using Physiologically-Based Pharmacokinetic Modeling.
Alice Ban Ke, Mark A Milad

Clin Pharmacol Ther· July 2019

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Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations.
Alice Ban Ke, Rick Greupink, Khaled Abduljalil

CPT Pharmacometrics Syst Pharmacol· February 2018

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Metformin's Intrinsic Blood-to-Plasma Partition Ratio (B/P): Reconciling the Perceived High In Vivo B/P > 10 with the In Vitro Equilibrium Value of Unity.
Fang Xie, Alice B Ke, Gary D Bowers, Maciej J Zamek-Gliszczynski

J Pharmacol Exp Ther· August 2015

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Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.
David S Small, Alice Ban Ke, Stephen D Hall, Nathan Mantlo, Matthew Rotelli

J Clin Pharmacol· July 2015

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Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1.
J William Higgins, Alice B Ke, Maciej J Zamek-Gliszczynski

Drug Metab Dispos· November 2014

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Pharmacometrics in pregnancy: An unmet need.
Alice Ban Ke, Amin Rostami-Hodjegan, Ping Zhao, Jashvant D Unadkat

Annu Rev Pharmacol Toxicol· September 2014

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Investigational small-molecule drug selectively suppresses constitutive CYP2B6 activity at the gene transcription level: physiologically based pharmacokinetic model assessment of clinical drug interaction risk.
Maciej J Zamek-Gliszczynski, Michael A Mohutsky, Jessica L F Rehmel, Alice B Ke

Drug Metab Dispos· June 2014

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Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.
Alice Ban Ke, Srikanth C Nallani, Ping Zhao, Amin Rostami-Hodjegan, Jashvant D Unadkat

Br J Clin Pharmacol· March 2014

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Utility of Oatp1a/1b-knockout and OATP1B1/3-humanized mice in the study of OATP-mediated pharmacokinetics and tissue distribution: case studies with pravastatin, atorvastatin, simvastatin, and carboxydichlorofluorescein.
J William Higgins, Jing Q Bao, Alice B Ke, Jason R Manro, John K Fallon

Drug Metab Dispos· January 2014

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A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women.
Alice Ban Ke, Srikanth C Nallani, Ping Zhao, Amin Rostami-Hodjegan, Nina Isoherranen

Drug Metab Dispos· April 2013

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Modeling cyclosporine A inhibition of the distribution of a P-glycoprotein PET ligand, 11C-verapamil, into the maternal brain and fetal liver of the pregnant nonhuman primate: impact of tissue blood flow and site of inhibition.
Alice Ban Ke, Sara Eyal, Francisco S Chung, Jeanne M Link, David A Mankoff

J Nucl Med· March 2013

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