Publications by authors named "Alice Rodriguez"

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Profiling the Impact of mGlu/Elfn1 Protein Interactions on the Pharmacology of mGlu Allosteric Modulators.
Xia Lei, Zixiu Xiang, Alice L Rodriguez, Margaret L Wilson, Colleen M Niswender

ACS Chem Neurosci· August 2025

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Discovery of a Novel sp‑Rich M Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping.
Joseph D Bungard, Paul Spearing, Yu Nishio, Upendra Rathnayake, Chris C Presley, Alice L Rodriguez

ACS Med Chem Lett· July 2025

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Discovery of Pre-Clinical Candidate /: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy.
Julie L Engers, Sean R Bollinger, Alison R Gregro, Rory A Capstick, Paul K Spearing, Alice L Rodriguez

ACS Chem Neurosci· June 2025

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Discovery of Thieno[3,2-]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
Katherine E Crocker, Scott H Henderson, Rory A Capstick, David L Whomble, Aaron M Bender, Alice L Rodriguez

ACS Med Chem Lett· May 2025

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Characterization of Novel and Known Activators of Cannabinoid Receptor Subtype 2 Reveals Mixed Pharmacology That Differentiates Mycophenolate Mofetil and GW-842,166X from MDA7.
Alice L Rodriguez, Aidong Qi, Allie Han, Haley E Kling, Marc C Quitalig

Int J Mol Sci· May 2025

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Application of Deuterium in an M Positive Allosteric Modulator Back-Up Program: The Discovery of VU6045422.
Julie L Engers, Jinming Li, Changho Han, Madeline F Long, Alison R Gregro, Alice L Rodriguez

ACS Chem Neurosci· April 2025

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Characteristics of lithic artifact weathering at the Semizbugu surface site complex in semi-arid Central Kazakhstan.
Emily Coco, Patrick Schimdt, Bin Hu, Alice Rodriguez, Talgat B Mamirov

Archaeol Anthropol Sci· March 2025

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Discovery of VU0467319: an M Positive Allosteric Modulator Candidate That Advanced into Clinical Trials.
Michael S Poslunsey, Michael R Wood, Changho Han, Shaun R Stauffer, Joseph D Panarese, Alice L Rodriguez

ACS Chem Neurosci· January 2025

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Discovery of 4-(5-Membered)Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5.
Elizabeth S Childress, Rory A Capstick, Katherine E Crocker, Miranda L Ledyard, Aaron M Bender, Alice L Rodriguez

ACS Med Chem Lett· December 2024

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Discovery of VU6007496: Challenges in the Development of an M Positive Allosteric Modulator Backup Candidate.
Julie L Engers, Katrina A Bollinger, Rory A Capstick, Madeline F Long, Aaron M Bender, Alice L Rodriguez

ACS Chem Neurosci· September 2024

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Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM).
Julie L Engers, Logan A Baker, Sichen Chang, Vincent B Luscombe, Alice L Rodriguez

ACS Chem Neurosci· September 2024

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Development of VU6036864: A Triazolopyridine-Based High-Quality Antagonist Tool Compound of the M Muscarinic Acetylcholine Receptor.
Jinming Li, Douglas L Orsi, Julie L Engers, Madeline F Long, Rory A Capstick, Alice L Rodriguez

J Med Chem· August 2024

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Discovery of VU6008677: A Structurally Distinct Tricyclic M Positive Allosteric Modulator with Improved CYP450 Profile.
Rory A Capstick, Sean R Bollinger, Julie L Engers, Madeline F Long, Sichen Chang, Alice L Rodriguez

ACS Med Chem Lett· August 2024

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The cannabinoid CB receptor positive allosteric modulator EC21a exhibits complicated pharmacology .
Aidong Qi, Xueqing Han, Marc Quitalig, Jessica Wu, Plamen P Christov, Alice L Rodriguez

J Recept Signal Transduct Res· August 2024

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Development of a Selective and High Affinity Radioligand, [H]VU6013720, for the M Muscarinic Receptor.
Aidong Qi, Haley E Kling, Natasha Billard, Alice L Rodriguez, Li Peng

Mol Pharmacol· November 2023

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Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7.
Xia Lei, Christopher S Hofmann, Alice L Rodriguez, Colleen M Niswender

Mol Pharmacol· July 2023

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Persistent challenges in the development of an mGlu PAM in vivo tool compound: The discovery of VU6046980.
Jacob J Kalbfleisch, Alice L Rodriguez, Xia Lei, Kelly Weiss, Annie L Blobaum

Bioorg Med Chem Lett· January 2023

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Discovery of a potent M antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists.
Douglas L Orsi, Andrew S Felts, Alice L Rodriguez, Paige N Vinson, Hyekyung P Cho

Bioorg Med Chem Lett· December 2022

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Discovery of a potent M antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists.
Rory A Capstick, David Whomble, Douglas L Orsi, Andrew S Felts, Alice L Rodriguez

Bioorg Med Chem Lett· November 2022

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Development and profiling of mGlu NAMs with a range of saturable inhibition of agonist responses in vitro.
Carson W Reed, Alice L Rodriguez, Jacob J Kalbfleisch, Mabel Seto, Matthew T Jenkins

Bioorg Med Chem Lett· October 2022

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The effect of worked material hardness on stone tool wear.
Alice Rodriguez, Kaushik Yanamandra, Lukasz Witek, Zhong Wang, Rakesh K Behera

PLoS One· October 2022

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Development of : A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder.
Aaron T Garrison, Douglas L Orsi, Rory A Capstick, David Whomble, Jinming Li, Alice L Rodriguez

J Med Chem· April 2022

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Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M muscarinic acetylcholine receptor.
Aaron M Bender, Trever R Carter, Matthew Spock, Alice L Rodriguez, Jonathan W Dickerson

Bioorg Med Chem Lett· January 2022

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Discovery of structurally distinct tricyclic M positive allosteric modulator (PAM) chemotypes - Part 2.
Madeline F Long, Rory A Capstick, Paul K Spearing, Julie L Engers, Alison R Gregro, Alice L Rodriguez

Bioorg Med Chem Lett· December 2021

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Craniopharyngioma, Chronotypes and Metabolic Risk Profile.
Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Domenico Solari, Enrico Riccio, Alice Rodriguez

Nutrients· September 2021

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