Publications by authors named "Andrea Pepper"

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Design, synthesis and evaluation of pyrrolobenzodiazepine (PBD)-based PROTAC conjugates for the selective degradation of the NF-κB RelA/p65 subunit.
Peiqin Jin, Md Mahbub Hasan, Andrea G S Pepper, Simon Mitchell, Khondaker Miraz Rahman, Chris Pepper

RSC Med Chem· September 2025

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Computational modelling of aggressive B-cell lymphoma.
Eleanor S Jayawant, Aimilia Vareli, Andrea Pepper, Chris Pepper, Fabio Simoes

Biochem Soc Trans· August 2025

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Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.
Aimilia Vareli, Haripriya Vaidehi Narayanan, Heather Clark, Eleanor Jayawant, Hui Zhou, Andrea Pepper, Chris Pepper

Cell Death Dis· August 2025

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Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL.
Aimilia Vareli, Haripriya Vaidehi Narayanan, Heather Clark, Eleanor Jayawant, Hui Zhou, Andrea Pepper, Chris Pepper

bioRxiv· February 2025

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A Novel In Vitro Model of the Bone Marrow Microenvironment in Acute Myeloid Leukemia Identifies CD44 and Focal Adhesion Kinase as Therapeutic Targets to Reverse Cell Adhesion-Mediated Drug Resistance.
Eleni E Ladikou, Kim Sharp, Fabio A Simoes, John R Jones, Thomas Burley, Chris J Pepper, Andrea G S Pepper

Cancers (Basel)· January 2025

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Patient-specific computational models predict prognosis in B cell lymphoma by quantifying pro-proliferative and anti-apoptotic signatures from genetic sequencing data.
Richard Norris, John Jones, Erika Mancini, Timothy Chevassut, Fabio A Simoes, Chris Pepper, Andrea Pepper

Blood Cancer J· July 2024

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Computational modeling of DLBCL predicts response to BH3-mimetics.
Ielyaas Cloete, Victoria M Smith, Ross A Jackson, Andrea Pepper, Chris Pepper

NPJ Syst Biol Appl· June 2023

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NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma.
Eleanor Jayawant, Arran Pack, Heather Clark, Emma Kennedy, Ankur Ghodke, Chris Pepper, Andrea Pepper

Front Oncol· June 2023

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NF-kB and the CLL microenvironment.
Alice O'Donnell, Chris Pepper, Simon Mitchell, Andrea Pepper

Front Oncol· March 2023

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Identification of proliferative and non-proliferative subpopulations of leukemic cells in CLL.
Kirsty M Cuthill, Yan Zhang, Andrea Pepper, Lies Boelen, Eve Coulter

Leukemia· September 2022

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Targeting the Non-Canonical NF-κB Pathway in Chronic Lymphocytic Leukemia and Multiple Myeloma.
Thomas A Burley, Emma Kennedy, Georgia Broad, Melanie Boyd, David Li, Andrea G S Pepper, Chris Pepper

Cancers (Basel)· March 2022

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Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia.
Thomas A Burley, Andrew Hesketh, Giselda Bucca, Emma Kennedy, Eleni E Ladikou, Andrea Pepper, Chris Pepper

Cancers (Basel)· March 2022

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Combined analysis of IGHV mutations, telomere length and CD49d identifies long-term progression-free survivors in TP53 wild-type CLL treated with FCR-based therapies.
Andrea G S Pepper, Antonella Zucchetto, Kevin Norris, Erika Tissino, Jerry Polesel, Chris Pepper

Leukemia· January 2022

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Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma.
Charlotte Elizabeth Graham, Agnieszka Jozwik, Ruby Quartey-Papafio, Nikolaos Ioannou, Ana M Metelo, Andrea Pepper

Leukemia· December 2021

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TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target.
Emma Kennedy, Eve Coulter, Emma Halliwell, Nuria Profitos-Peleja, Elisabeth Walsby, Chris Pepper, Andrea G S Pepper

Blood· June 2021

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Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers.
Thomas Lewis, David B Corcoran, David E Thurston, Peter J Giles, Kevin Ashelford, Andrea G S Pepper, Chris Pepper

Haematologica· April 2021

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The architecture of neoplastic follicles in follicular lymphoma; analysis of the relationship between the tumor and follicular helper T cells.
William Townsend, Marta Pasikowska, Deborah Yallop, Elizabeth H Phillips, Piers E M Patten, Andrea Pepper

Haematologica· June 2020

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Dissecting the role of the CXCL12/CXCR4 axis in acute myeloid leukaemia.
Eleni E Ladikou, Timothy Chevassut, Chris J Pepper, Andrea Gs Pepper

Br J Haematol· June 2020

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Allogeneic CAR-T Cells: More than Ease of Access?
Charlotte Graham, Agnieszka Jozwik, Andrea Pepper, Reuben Benjamin

Cells· October 2018

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Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells.
Silvia Mele, Stephen Devereux, Andrea G Pepper, Elvira Infante, Anne J Ridley

Blood Adv· July 2018

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and evidence for uncoupling of B-cell receptor internalization and signaling in chronic lymphocytic leukemia.
Eve M Coulter, Andrea Pepper, Silvia Mele, Najeem'deen Folarin, William Townsend

Haematologica· March 2018

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