Publications by authors named "Andrea Testa"

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Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9.
Scott J Hughes, Wojciech J Stec, Colin T R Davies, David McGarry, Alicia Williams, Andrea Testa

Nat Commun· October 2025

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Correction to "Development of BromoTag: A "Bump-and-Hole"-PROTAC System To Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins".
Adam G Bond, Conner Craigon, Kwok-Ho Chan, Andrea Testa, Athanasios Karapetsas

J Med Chem· February 2025

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Phase-separated droplets swim to their dissolution.
Etienne Jambon-Puillet, Andrea Testa, Charlotta Lorenz, Robert W Style, Aleksander A Rebane

Nat Commun· May 2024

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Targeted protein degradation via intramolecular bivalent glues.
Oliver Hsia, Matthias Hinterndorfer, Angus D Cowan, Kentaro Iso, Tasuku Ishida, Andrea Testa

Nature· March 2024

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Affinity for both sides.
Andrea Testa

Nat Chem Biol· February 2024

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Surface Passivation Method for the Super-repellence of Aqueous Macromolecular Condensates.
Andrea Testa, Hendrik T Spanke, Etienne Jambon-Puillet, Mohammad Yasir, Yanxia Feng

Langmuir· October 2023

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Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Sarath Ramachandran, Nikolai Makukhin, Kevin Haubrich, Manjula Nagala, Beth Forrester, Andrea Testa

Nat Commun· October 2023

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The 17 EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders.
Alessio Ciulli, Suzanne O'Connor, Chun-Wa Chung, Ingo V Hartung, Andrea Testa

ChemMedChem· October 2023

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Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.
Alexander Hanzl, Ryan Casement, Hana Imrichova, Scott J Hughes, Eleonora Barone, Andrea Testa

Nat Chem Biol· March 2023

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"Stay at Home" during the COVID-19 Pandemic: Effects on Physical Activity and Sedentary Behavior in an Italian Academic Community.
Anna Mulasso, Margherita Micheletti Cremasco, Simone Cuomo, Andrea Testa, Lynda Stella Lattke

Int J Environ Res Public Health· January 2023

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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Andrea Testa

Nat Commun· April 2022

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The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type.
Chiara Tarantelli, Eleonora Cannas, Hillarie Ekeh, Carmelo Moscatello, Eugenio Gaudio, Andrea Testa

Explor Target Antitumor Ther· December 2021

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The rise and rise of protein degradation: Opportunities and challenges ahead.
Scott J Hughes, Andrea Testa, Nicola Thompson, Ian Churcher

Drug Discov Today· December 2021

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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity.
Satomi Imaide, Kristin M Riching, Nikolai Makukhin, Vesna Vetma, Claire Whitworth, Andrea Testa

Nat Chem Biol· November 2021

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Sustained enzymatic activity and flow in crowded protein droplets.
Andrea Testa, Mirco Dindo, Aleksander A Rebane, Babak Nasouri, Robert W Style

Nat Commun· November 2021

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Development of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins.
Adam G Bond, Conner Craigon, Kwok-Ho Chan, Andrea Testa, Athanasios Karapetsas

J Med Chem· October 2021

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Relation among Perceived Weight Change, Sedentary Activities and Sleep Quality during COVID-19 Lockdown: A Study in an Academic Community in Northern Italy.
Margherita Micheletti Cremasco, Anna Mulasso, Alessia Moroni, Andrea Testa, Raffaella Degan

Int J Environ Res Public Health· March 2021

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Stereoselective synthesis of allele-specific BET inhibitors.
Adam G Bond, Andrea Testa, Alessio Ciulli

Org Biomol Chem· October 2020

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.
Luke M Simpson, Thomas J Macartney, Alice Nardin, Luke J Fulcher, Sascha Röth, Andrea Testa

Cell Chem Biol· September 2020

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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.
Victoria G Klein, Chad E Townsend, Andrea Testa, Michael Zengerle, Chiara Maniaci

ACS Med Chem Lett· September 2020

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Structure-Based Design of a Macrocyclic PROTAC.
Andrea Testa, Scott J Hughes, Xavier Lucas, Jane E Wright, Alessio Ciulli

Angew Chem Int Ed Engl· January 2020

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Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader.
Hannah Tovell, Andrea Testa, Houjiang Zhou, Natalia Shpiro, Claire Crafter

ACS Chem Biol· September 2019

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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs.
Miriam Girardini, Chiara Maniaci, Scott J Hughes, Andrea Testa, Alessio Ciulli

Bioorg Med Chem· June 2019

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Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader.
Hannah Tovell, Andrea Testa, Chiara Maniaci, Houjiang Zhou, Alan R Prescott

ACS Chem Biol· May 2019

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Correction to "3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation".
Andrea Testa, Xavier Lucas, Guilherme V Castro, Kwok-Ho Chan, Jane E Wright

J Am Chem Soc· May 2019

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