Publications by authors named "Andreas Maderna"

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Building Machine Learning Small Molecule Melting Points and Solubility Models Using CCDC Melting Points Dataset.
Xiangwei Zhu, Valery R Polyakov, Krishna Bajjuri, Huiyong Hu, Andreas Maderna

J Chem Inf Model· May 2023

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Indexing Ultrafast Shape-Based Descriptors in MongoDB to Identify TLR4 Pathway Agonists.
Valery R Polyakov, Vadim Alexandrov, Andreas Maderna, Krishna Bajjuri, Xiaofan Li

J Chem Inf Model· May 2022

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NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Kenneth G Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Andreas Maderna

Cell Rep Med· May 2021

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Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia.
Yoon-Chi Han, Jennifer Kahler, Nicole Piché-Nicholas, Wenyue Hu, Stephane Thibault, Andreas Maderna

Clin Cancer Res· January 2021

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Novel Anti-TM4SF1 Antibody-Drug Conjugates with Activity against Tumor Cells and Tumor Vasculature.
Alberto Visintin, Kelly Knowlton, Edyta Tyminski, Chi-Iou Lin, Xiang Zheng, Andreas Maderna

Mol Cancer Ther· August 2015

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Recent advances in the development of new auristatins: structural modifications and application in antibody drug conjugates.
Andreas Maderna, Carolyn A Leverett

Mol Pharm· June 2015

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Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.
Frank Loganzo, Xingzhi Tan, Matthew Sung, Guixian Jin, Jeremy S Myers, Andreas Maderna

Mol Cancer Ther· April 2015

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Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
Andreas Maderna, Matthew Doroski, Chakrapani Subramanyam, Alexander Porte, Carolyn A Leverett

J Med Chem· December 2014

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Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide.
Damien Mailhol, Jens Willwacher, Nina Kausch-Busies, Elizabeth E Rubitski, Zhanna Sobol, Andreas Maderna

J Am Chem Soc· November 2014

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New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation.
Zecheng Chen, Andreas Maderna, Sai Chetan K Sukuru, Melissa Wagenaar, Christopher J O'Donnell

Bioorg Med Chem Lett· December 2013

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Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.
Kévin Micoine, Peter Persich, Josep Llaveria, My-Hanh Lam, Andreas Maderna

Chemistry· June 2013

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Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis.
Kyung-Hee Kim, Andreas Maderna, Mark E Schnute, Martin Hegen, Shashi Mohan

Bioorg Med Chem Lett· November 2011

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RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.
Cory Iverson, Gary Larson, Chon Lai, Li-Tain Yeh, Claudia Dadson, Andreas Maderna

Cancer Res· September 2009

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Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors.
Hassan El Abdellaoui, Chamakura V N S Varaprasad, Dinesh Barawkar, Subrata Chakravarty, Andreas Maderna

Bioorg Med Chem Lett· November 2006

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Organic syntheses on an icosahedral borane surface: closomer structures with twelvefold functionality.
Tiejun Li, Satish S Jalisatgi, Michael J Bayer, Andreas Maderna, Saeed I Khan

J Am Chem Soc· December 2005

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Microwave-assisted allylation of acetals with allyltrimethylsilane in the presence of CuBr.
Michael E Jung, Andreas Maderna

J Org Chem· October 2004

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Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer.
Andreas Maderna, Ramon Huertas, M Frederick Hawthorne, Raymond Luguya, M Graça H Vicente

Chem Commun (Camb)· August 2002

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Twelvefold Functionalization of an Icosahedral Surface by Total Esterification of [B12(OH)12]2-: 12(12)-Closomers.
Andreas Maderna, Carolyn B. Knobler, M. Frederick Hawthorne

Angew Chem Int Ed Engl· August 2001

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Twelvefold Functionalization of an Icosahedral Surface by Total Esterification of.
Andreas Maderna, Carolyn B. Knobler, M. Frederick Hawthorne

Angew Chem Int Ed Engl· May 2001

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Applications of Radiolabeled Boron Clusters to the Diagnosis and Treatment of Cancer.
M. Frederick Hawthorne, Andreas Maderna

Chem Rev· December 1999

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Camouflaged Carboranes as Surrogates for C(60): Syntheses of Functionalized Derivatives by Selective Hydroxyalkylation.
Axel Herzog, Carolyn B. Knobler, M. Frederick Hawthorne, Andreas Maderna, Walter Siebert

J Org Chem· February 1999

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