Publications by authors named "Andrew Huber"

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Displacement of Bilirubin From Albumin by Omegaven and Intralipid.
Alan Kleinfeld, Andrew Huber, William Oh, Thomas Hegyi

J Pediatr Surg· December 2025

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Unbound free fatty acids from intralipid displace bilirubin from albumin, comparable to sulfisoxazole.
Thomas Hegyi, Andrew Huber, William Oh, Alan Kleinfeld

Pediatr Res· December 2025

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PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors.
Andrew D Huber, Wenwei Lin, Young-Hwan Jung, Shyaron Poudel, Guangwei Yang

Nat Commun· November 2025

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Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators.
Andrew D Huber, Efren Garcia-Maldonado, Wenwei Lin, Shyaron Poudel, Jing Wu

Structure· October 2025

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The Effect of Conjugated Bilirubin on the Measurement of Unbound Bilirubin.
Alan Kleinfeld, Andrew Huber, William Oh, Thomas Hegyi

Acta Paediatr· October 2025

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Factors Affecting the Relationship Between Total and Unbound Bilirubin in Preterm and Term Infants.
Thomas Hegyi, Dalya Chefitz, Alan Weller, Andrew Huber, Mary Carayannopoulos

Acta Paediatr· August 2025

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PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network.
Andrew D Huber, Wenwei Lin, Shyaron Poudel, Darcie J Miller, Taosheng Chen

Structure· December 2024

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Addition/Correction to "First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy".
Andrew D Huber, Young-Hwan Jung, Yongtao Li, Wenwei Lin, Jing Wu

J Med Chem· December 2024

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First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy.
Andrew D Huber, Young-Hwan Jung, Yongtao Li, Wenwei Lin, Jing Wu

J Med Chem· October 2024

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A new mode of inhibition.
Andrew D Huber, Taosheng Chen

Elife· August 2024

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CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer.
Ming Shao, Qingfei Pan, Haiyan Tan, Jing Wu, Ha Won Lee, Andrew D Huber

Genes Dis· July 2024

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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR.
Efren Garcia-Maldonado, Andrew D Huber, Sergio C Chai, Stanley Nithianantham, Yongtao Li

Nat Commun· May 2024

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Regulation of PXR in drug metabolism: chemical and structural perspectives.
Rebecca R Florke Gee, Andrew D Huber, Taosheng Chen

Expert Opin Drug Metab Toxicol· March 2024

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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Andrew D Huber, Shyaron Poudel, Jing Wu, Darcie J Miller, Wenwei Lin

Nucleic Acids Res· February 2024

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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.
Andrew D Huber, Shyaron Poudel, Yongtao Li, Wenwei Lin, Jing Wu

Structure· December 2023

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The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation.
Rebecca R Florke Gee, Andrew D Huber, Jing Wu, Richa Bajpai, Allister J Loughran

Acta Pharm Sin B· November 2023

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Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial.
Lindsay F Holzapfel, Cody Arnold, Jon E Tyson, Steven M Shapiro, Eric W Reynolds, Andrew H Huber

BMC Pediatr· July 2023

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Mechanisms of Action of the Host-Targeting Agent Cyclosporin A and Direct-Acting Antiviral Agents against Hepatitis C Virus.
Dandan Liu, Tanya P Ndongwe, Juan Ji, Andrew D Huber, Eleftherios Michailidis

Viruses· April 2023

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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.
Wenwei Lin, Andrew D Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman

Proc Natl Acad Sci U S A· March 2023

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Effect of Reduced Versus Usual Lipid Emulsion Dosing on Bilirubin Neurotoxicity and Neurodevelopmental Impairment in Extremely Preterm Infants: Study Protocol for a Randomized Controlled Trial.
Lindsay Holzapfel, Cody Arnold, Jon Tyson, Steven Shapiro, Eric Reynolds, Andrew Huber

Res Sq· March 2023

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Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond.
Shyaron Poudel, Andrew D Huber, Taosheng Chen

Drug Metab Dispos· February 2023

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Effects of lipid emulsions on unbound bilirubin and response to phototherapy in preterm infants.
Jonathan Sasenick, Alan Kleinfeld, Andrew Huber, William Oh, Thomas Hegyi

J Matern Fetal Neonatal Med· December 2022

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SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.
Andrew D Huber, Yongtao Li, Wenwei Lin, Annalise N Galbraith, Ashutosh Mishra

ACS Med Chem Lett· August 2022

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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber

Nucleic Acids Res· April 2022

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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.
Jingheng Wang, Cameron D Buchman, Jayaraman Seetharaman, Darcie J Miller, Andrew D Huber

J Am Chem Soc· November 2021

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