Publications by authors named "Andrew Leach"

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Temporal trends in evidence supporting novel drug target discovery.
Maria J Falaguera, Ellen M McDonagh, David Ochoa, Polina V Rusina, Juan Maria Roldan-Romero, Andrew R Leach

Nat Commun· December 2025

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Leveraging large-scale biobanks for therapeutic target discovery.
Brian R Ferolito, Hesam Dashti, Claudia Giambartolomei, Gina M Peloso, Daniel J Golden, Andrew R Leach

HGG Adv· December 2025

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Correction to "Pseudonatural Products for Chemical Biology and Drug Discovery".
Luca C Greiner, Axel Pahl, A Lina Heinzke, Barbara Zdrazil, Andrew R Leach

J Med Chem· November 2025

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ChEBI: re-engineered for a sustainable future.
Adnan Malik, Muhammad Arsalan, Carlos Moreno, Juan Mosquera, Eloy Félix, Andrew R Leach

Nucleic Acids Res· November 2025

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EnsembleFlex: Protein structure ensemble analysis made easy.
Melanie Schneider, José Antonio Marquez, Andrew R Leach

Structure· October 2025

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Design and synthesis of a chemically diverse, lead-like DNA-encoded library from sequential amide coupling.
Cameron E Taylor, Grace Roper, Rhianna Young, Fredrik Svensson, Andreas Brunschweiger, Andrew G Leach

RSC Med Chem· October 2025

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Drug and Clinical Candidate Drug Data in ChEMBL.
Fiona M I Hunter, Harris Ioannidis, A Patrícia Bento, Nicolas Bosc, Sybilla Corbett, Andrew R Leach

J Med Chem· October 2025

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The Boroxine-Boronic Acid Equilibrium.
Chen Li, Lia Sotorrios, Patrick J Boaler, Valentas Olikauskas, Matteo Amico, Andrew G Leach

J Am Chem Soc· October 2025

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Pseudonatural Products for Chemical Biology and Drug Discovery.
Luca C Greiner, Axel Pahl, A Lina Heinzke, Barbara Zdrazil, Andrew R Leach

J Med Chem· July 2025

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Corrigendum to "Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride" [J. Colloid Interface Sci. 683 (2025) 1135-1149].
Yixuan Yan, Yichun Shen, Najet Mahmoudi, Peixun Lic, James Tellam, Andrew G Leach

J Colloid Interface Sci· May 2025

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Dynamic self-assembled meso-structures formed across a wide concentration range in aqueous solutions of propranolol hydrochloride.
Yixuan Yan, Yichun Shen, Najet Mahmoudi, Peixun Li, James Tellam, Andrew G Leach

J Colloid Interface Sci· April 2025

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Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction.
Danielle Rasooly, Claudia Giambartolomei, Gina M Peloso, Hesam Dashti, Brian R Ferolito, Andrew R Leach

Nat Cardiovasc Res· March 2025

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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Claudia Tredup, Suzanne Ackloo, Hartmut Beck, Peter J Brown, Alex N Bullock, Andrew R Leach

RSC Med Chem· February 2025

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Photoswitchable Azobispyrazole Crystals Achieving Near-Quantitative Crystalline-State Bidirectional ⇆ Conversions.
Yixin He, Tongtong Dang, Andrew G Leach, Zhao-Yang Zhang, Tao Li

J Am Chem Soc· October 2024

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A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds.
A Lina Heinzke, Barbara Zdrazil, Paul D Leeson, Robert J Young, Axel Pahl, Andrew R Leach

Sci Data· October 2024

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Occurrence of "Natural Selection" in Successful Small Molecule Drug Discovery.
A Lina Heinzke, Axel Pahl, Barbara Zdrazil, Andrew R Leach, Herbert Waldmann

J Med Chem· July 2024

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A data science roadmap for open science organizations engaged in early-stage drug discovery.
Kristina Edfeldt, Aled M Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, Andrew R Leach

Nat Commun· July 2024

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Accessing Rare α-Heterocyclic Aziridines via Brønsted Acid-catalyzed Michael Addition/Annulation: Scope, Limitations, and Mechanism.
Timothy A Hilton, Andrew G Leach, Aidan P McKay, Allan J B Watson

Chemistry· April 2024

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Overview of the Knowledge Management Center for Illuminating the Druggable Genome.
Tudor I Oprea, Cristian Bologa, Jayme Holmes, Stephen Mathias, Vincent T Metzger, Andrew R Leach

Drug Discov Today· March 2024

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The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods.
Barbara Zdrazil, Eloy Felix, Fiona Hunter, Emma J Manners, James Blackshaw, Andrew R Leach

Nucleic Acids Res· January 2024

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EMBL's European Bioinformatics Institute (EMBL-EBI) in 2023.
Matthew Thakur, Annalisa Buniello, Catherine Brooksbank, Kim T Gurwitz, Matthew Hall, Andrew R Leach

Nucleic Acids Res· January 2024

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Challenges and perspectives for naming lipids in the context of lipidomics.
Michael Witting, Adnan Malik, Andrew Leach, Alan Bridge, Lucila Aimo

Metabolomics· January 2024

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Editorial overview: Restructuring drug design and development.
Andrew R Leach, Alison E Ondrus

Curr Opin Struct Biol· December 2023

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MAIP: An Open-Source Tool to Enrich High-Throughput Screening Output and Identify Novel, Druglike Molecules with Antimalarial Activity.
Nicolas Bosc, Eloy Felix, J Mark F Gardner, James Mills, Martijn Timmerman, Andrew R Leach

ACS Med Chem Lett· December 2023

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Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium.
Paula I Seoane, James A Beswick, Andrew G Leach, Tessa Swanton, Lucy V Morris

Cell Death Discov· December 2023

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