Publications by authors named "Andrew Messer"

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5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I.
Zeyu Yang, Alice M Sheehan, Mary Papadaki, Andrew E Messer, Brian S J Blagg

ACS Pharmacol Transl Sci· May 2025

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Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations , , and .
Zeyu Yang, Alice M Sheehan, Andrew E Messer, Sharmane Tsui, Alexander Sparrow

Front Physiol· December 2024

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Donor hearts in the Sydney Heart Bank: reliable control but is it 'normal' heart?
Steven Marston, Adam Jacques, Christopher Bayliss, Emma Dyer, Massimiliano Memo, Andrew Messer

Biophys Rev· August 2020

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Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis.
O'neal Copeland, Andrew Messer, Andrew Jabbour, Corrado Poggesi, Sanjay Prasad

Front Physiol· March 2020

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The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM.
Nicoletta Piroddi, E Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Andrew Messer

J Gen Physiol· January 2019

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Temperature-sensitive sarcomeric protein post-translational modifications revealed by top-down proteomics.
Wenxuan Cai, Zachary L Hite, Beini Lyu, Zhijie Wu, Ziqing Lin, Andrew E Messer

J Mol Cell Cardiol· September 2018

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Author Correction: Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.
Petr G Vikhorev, Natalia Smoktunowicz, Alex B Munster, O' Neal Copeland, Sawa Kostin, Andrew E Messer

Sci Rep· September 2018

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Molecular Defects in Cardiac Myofilament Ca-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.
Alice Sheehan, Andrew E Messer, Maria Papadaki, Afnan Choudhry, Vladimír Kren

Front Physiol· March 2018

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Development of apical hypertrophic cardiomyopathy with age in a transgenic mouse model carrying the cardiac actin E99K mutation.
Li Wang, Fan Bai, Qing Zhang, Weihua Song, Andrew Messer

J Muscle Res Cell Motil· December 2017

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Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.
Petr G Vikhorev, Natalia Smoktunowicz, Alex B Munster, O'Neal Copeland, Sawa Kostin, Andrew E Messer

Sci Rep· November 2017

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Investigations into the Sarcomeric Protein and Ca-Regulation Abnormalities Underlying Hypertrophic Cardiomyopathy in Cats ().
Andrew E Messer, Jasmine Chan, Alex Daley, O'Neal Copeland, Steven B Marston

Front Physiol· June 2017

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Myopathy-inducing mutation H40Y in ACTA1 hampers actin filament structure and function.
Chun Chan, Jun Fan, Andrew E Messer, Steve B Marston, Hiroyuki Iwamoto

Biochim Biophys Acta· August 2016

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Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.
Andrew E Messer, Christopher R Bayliss, Mohammed El-Mezgueldi, Charles S Redwood, Douglas G Ward

Arch Biochem Biophys· July 2016

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Troponin structure: its modulation by Ca(2+) and phosphorylation studied by molecular dynamics simulations.
Juan Eiros Zamora, Maria Papadaki, Andrew E Messer, Steven B Marston, Ian R Gould

Phys Chem Chem Phys· July 2016

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OBSCN Mutations Associated with Dilated Cardiomyopathy and Haploinsufficiency.
Steven Marston, Cecile Montgiraud, Alex B Munster, O'Neal Copeland, Onjee Choi, Andrew E Messer

PLoS One· May 2016

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'(De-)sensitization' vs. 'Uncoupling': what drives cardiomyopathies in the thin filament? Reply.
Steven Marston, Andrew Messer, Maria Papadaki

Cardiovasc Res· January 2016

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Uncoupling of myofilament Ca2+ sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate.
Maria Papadaki, Petr G Vikhorev, Steven B Marston, Andrew E Messer

Cardiovasc Res· October 2015

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The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I.
Petr G Vikhorev, Weihua Song, Ross Wilkinson, O'Neal Copeland, Andrew E Messer

Biophys J· November 2014

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Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy.
Andrew E Messer, Steven B Marston

Front Physiol· September 2014

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Mutations in repeating structural motifs of tropomyosin cause gain of function in skeletal muscle myopathy patients.
Steven Marston, Massimiliano Memo, Andrew Messer, Maria Papadaki, Kristen Nowak

Hum Mol Genet· December 2013

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Tropomyosin isoform expression and phosphorylation in the human heart in health and disease.
Steven B Marston, O'Neal Copeland, Andrew E Messer, Elyshia MacNamara, Kristen Nowak

J Muscle Res Cell Motil· August 2013

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Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca²⁺ sensitivity.
Massimiliano Memo, Man-Ching Leung, Douglas G Ward, Cristobal dos Remedios, Sachio Morimoto, Andrew E Messer

Cardiovasc Res· July 2013

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Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Christopher R Bayliss, Adam M Jacques, Man-Ching Leung, Douglas G Ward, Charles S Redwood, Andrew E Messer

Cardiovasc Res· March 2013

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Z-band alternatively spliced PDZ motif protein (ZASP) is the major O-linked β-N-acetylglucosamine-substituted protein in human heart myofibrils.
Man-Ching Leung, Paul G Hitchen, Douglas G Ward, Andrew E Messer, Steven B Marston

J Biol Chem· February 2013

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Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.
Weihua Song, Emma Dyer, Daniel J Stuckey, O'Neal Copeland, Man-Ching Leung, Andrew Messer

J Biol Chem· August 2011

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