Publications by authors named "Andrew Plump"

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Identifying and Validating New Drug Targets for Stroke and Beyond: Can Mendelian Randomization Help?
Andrew Plump, George Davey Smith

Circulation· September 2019

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Biomarkers in the pharmaceutical industry.
Omar F Laterza, Andrew Plump, Jeffrey E Ming, Susan Richards, Michael E Ransom Burczynski

Clin Chem· April 2015

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Racing to define pharmaceutical R&D external innovation models.
Liangsu Wang, Andrew Plump, Michael Ringel

Drug Discov Today· March 2015

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Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.
Roshni R Singaraja, Ian Tietjen, G Kees Hovingh, Patrick L Franchini, Chris Radomski, Andrew Plump

J Lipid Res· August 2014

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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
Dan E Arking, Sara L Pulit, Lia Crotti, Pim van der Harst, Patricia B Munroe, Andrew S Plump

Nat Genet· August 2014

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Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs.
Xiaoling Zhang, Hinco J Gierman, Daniel Levy, Andrew Plump, Radu Dobrin

BMC Genomics· June 2014

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Differential profiles of thrombin inhibitors (heparin, hirudin, bivalirudin, and dabigatran) in the thrombin generation assay and thromboelastography in vitro.
Yiming Xu, Weizhen Wu, Liangsu Wang, Madhu Chintala, Andrew S Plump

Blood Coagul Fibrinolysis· April 2013

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11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature.
Mingjuan J Luo, Rolf Thieringer, Martin S Springer, Samuel D Wright, Anne Hermanowski-Vosatka, Andrew Plump

Physiol Genomics· January 2013

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Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression.
Brett Lauring, Andrew K P Taggart, James R Tata, Richard Dunbar, Luzelena Caro, Andrew Plump

Sci Transl Med· August 2012

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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes.
Liwen Zhang, Timothy McCabe, Jon H Condra, Yan G Ni, Laurence B Peterson, Andrew S Plump

Int J Biol Sci· July 2012

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Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
Weihong Tang, Christine Schwienbacher, Lorna M Lopez, Yoav Ben-Shlomo, Tiphaine Oudot-Mellakh, Andrew S Plump

Am J Hum Genet· July 2012

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Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters.
Zhu Chen, Sheng-ping Wang, Mihajlo L Krsmanovic, Jose Castro-Perez, Karen Gagen, Andrew S Plump

Metabolism· April 2012

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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Lisette Stolk, John R B Perry, Daniel I Chasman, Chunyan He, Massimo Mangino, Andrew S Plump

Nat Genet· January 2012

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AAV8-mediated long-term expression of human LCAT significantly improves lipid profiles in hCETP;Ldlr(+/-) mice.
Zhu Chen, Donald Chu, Jose M Castro-Perez, Weihua Ni, Aiwu Zhang, Andrew S Plump

J Cardiovasc Transl Res· December 2011

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A gene expression signature that classifies human atherosclerotic plaque by relative inflammation status.
Oscar Puig, Jeffrey Yuan, Sergey Stepaniants, Renata Zieba, Emanuel Zycband, Andrew Plump

Circ Cardiovasc Genet· December 2011

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High-throughput simultaneous analysis of RNA, protein, and lipid biomarkers in heterogeneous tissue samples.
Vladimír Reiser, Ryan C Smith, Jiyan Xue, Marc M Kurtz, Rong Liu, Andrew S Plump

Clin Chem· November 2011

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Heart failure drug discovery: scarred or ready for remodeling?
Andrew Plump, Jeffrey Madwed

J Mol Cell Cardiol· October 2011

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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, Andrew Plump

Nat Genet· September 2011

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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Nature· September 2011

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Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
Cathy E Elks, John R B Perry, Patrick Sulem, Daniel I Chasman, Nora Franceschini, Andrew S Plump

Nat Genet· December 2010

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Accelerating the pulse of cardiovascular R&D.
Andrew Plump

Nat Rev Drug Discov· November 2010

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Identification and validation of genes affecting aortic lesions in mice.
Xia Yang, Larry Peterson, Rolf Thieringer, Joshua L Deignan, Xuping Wang, Andrew Plump

J Clin Invest· July 2010

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Cholesterol in human atherosclerotic plaque is a marker for underlying disease state and plaque vulnerability.
Zhu Chen, Marina Ichetovkin, Marc Kurtz, Emanuel Zycband, Douglas Kawka, Andrew S Plump

Lipids Health Dis· June 2010

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Genomics and cardiovascular drug development.
Andrew S Plump, Pek Yee Lum

J Am Coll Cardiol· March 2009

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Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis.
Phyllis Strickland, Grace C Shin, Andrew Plump, Marc Tessier-Lavigne, Lindsay Hinck

Development· March 2006

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