Publications by authors named "Andrew Polson"

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Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas.
Stephen J Schuster, Ling-Yuh Huw, Christopher R Bolen, Victor Maximov, Andrew G Polson

Blood· February 2024

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T cell-Dependent Bispecific Therapy Enhances Innate Immune Activation and Antibody-Mediated Killing.
Rickvinder Besla, Elicia Penuel, Geoff Del Rosario, Ely Cosino, Szymon Myrta, Andrew G Polson

Cancer Immunol Res· January 2024

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Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study.
Elisabeth A Lasater, Dhara N Amin, Rajat Bannerji, Raghuveer Singh Mali, Kathy Barrett, Andrew G Polson

Am J Hematol· March 2023

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Development of T-cell engagers selective for cells co-expressing two antigens.
Danielle M Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Andrew G Polson

MAbs· October 2022

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Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia.
Lennart Lenk, Dorothee Winterberg, Fotini Vogiatzi, Anna Laqua, Lea Spory, Andrew G Polson

Hemasphere· August 2022

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Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Peiyin Wang, Liping L Sun, Robyn Clark, Maria Hristopoulos, Cecilia P C Chiu, Andrew G Polson

Mol Cancer Ther· June 2022

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Anti-CD79B Antibody-Drug Conjugate DCDS0780A in Patients with B-Cell Non-Hodgkin Lymphoma: Phase 1 Dose-Escalation Study.
Alex F Herrera, Manish R Patel, John M Burke, Ranjana Advani, Bruce D Cheson, Andrew G Polson

Clin Cancer Res· April 2022

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A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.
Satoko Kakiuchi-Kiyota, Thorsten Ross, Heidi Ackerly Wallweber, James R Kiefer, Melissa M Schutten, Andrew G Polson

Leukemia· April 2022

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A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides.
Neelie Zacharias, Vladimir N Podust, Kimberly K Kajihara, Douglas Leipold, Geoffrey Del Rosario, Andrew Polson

Chem Sci· March 2022

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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response.
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Andrew G Polson

MAbs· October 2021

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Calicheamicin Antibody-Drug Conjugates with Improved Properties.
Breanna S Vollmar, Chris Frantz, Melissa M Schutten, Fiona Zhong, Geoffrey Del Rosario, Andrew G Polson

Mol Cancer Ther· June 2021

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An Anti-CD22--CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models.
Shang-Fan Yu, Donna W Lee, Bing Zheng, Geoffrey Del Rosario, Douglas Leipold, Andrew G Polson

Mol Cancer Ther· February 2021

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Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin.
Dongwei Li, Donna Lee, Randall C Dere, Bing Zheng, Shang-Fan Yu, Andrew G Polson

Br J Pharmacol· October 2019

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Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Donglu Zhang, Peter S Dragovich, Shang-Fan Yu, Yong Ma, Thomas H Pillow, Andrew Polson

Drug Metab Dispos· October 2019

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Preclinical pharmacokinetics and pharmacodynamics of DCLL9718A: An antibody-drug conjugate for the treatment of acute myeloid leukemia.
Douglas D Leipold, Isabel Figueroa, Shabkhaiz Masih, Brandon Latifi, Victor Yip, Andrew G Polson

MAbs· June 2019

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Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Dian Su, Jinhua Chen, Ely Cosino, Josefa Dela Cruz-Chuh, Helen Davis, Andrew G Polson

Bioconjug Chem· May 2019

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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia.
Bing Zheng, Shang-Fan Yu, Geoffrey Del Rosario, Steven R Leong, Genee Y Lee, Andrew G Polson

Clin Cancer Res· February 2019

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Phase I study of the anti-FcRH5 antibody-drug conjugate DFRF4539A in relapsed or refractory multiple myeloma.
A Keith Stewart, Amrita Y Krishnan, Seema Singhal, Ralph V Boccia, Manish R Patel, Andrew G Polson

Blood Cancer J· February 2019

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Prediction of non-linear pharmacokinetics in humans of an antibody-drug conjugate (ADC) when evaluation of higher doses in animals is limited by tolerability: Case study with an anti-CD33 ADC.
Isabel Figueroa, Doug Leipold, Steve Leong, Bing Zheng, Montserrat Triguero-Carrasco, Andrew G Polson

MAbs· July 2018

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Intratumoral Payload Concentration Correlates with the Activity of Antibody-Drug Conjugates.
Donglu Zhang, Shang-Fan Yu, S Cyrus Khojasteh, Yong Ma, Thomas H Pillow, Andrew G Polson

Mol Cancer Ther· March 2018

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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates.
Niña G Caculitan, Josefa Dela Cruz Chuh, Yong Ma, Donglu Zhang, Katherine R Kozak, Andrew G Polson

Cancer Res· December 2017

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Design, synthesis, and biological evaluation of pyrrolobenzodiazepine-containing hypoxia-activated prodrugs.
Peter S Dragovich, Fabio Broccatelli, Jinhua Chen, Peter Fan, Hoa Le, Andrew G Polson

Bioorg Med Chem Lett· December 2017

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Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers.
Stephen J Gregson, Luke A Masterson, Binqing Wei, Thomas H Pillow, Susan D Spencer, Andrew Polson

J Med Chem· December 2017

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Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors.
Leanna R Staben, Shang-Fan Yu, Jinhua Chen, Gang Yan, Zijin Xu, Andrew G Polson

ACS Med Chem Lett· October 2017

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Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
Thomas H Pillow, Melissa Schutten, Shang-Fan Yu, Rachana Ohri, Jack Sadowsky, Andrew G Polson

Mol Cancer Ther· May 2017

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