Publications by authors named "Andrew S Cook"

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Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
Rishi G Vaswani, Victor S Gehling, Les A Dakin, Andrew S Cook, Christopher G Nasveschuk

J Med Chem· November 2016

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Discovery, design, and synthesis of indole-based EZH2 inhibitors.
Victor S Gehling, Rishi G Vaswani, Christopher G Nasveschuk, Martin Duplessis, Priyadarshini Iyer, Andrew S Cook

Bioorg Med Chem Lett· September 2015

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EZH2 inhibitor efficacy in non-Hodgkin's lymphoma does not require suppression of H3K27 monomethylation.
William D Bradley, Shilpi Arora, Jennifer Busby, Srividya Balasubramanian, Victor S Gehling, Andrew S Cook

Chem Biol· November 2014

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Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Qinhua Huang, Ted W Johnson, Simon Bailey, Alexei Brooun, Kevin D Bunker, Andrew S Cook

J Med Chem· February 2014

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Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.
Paul V Fish, Panagis Filippakopoulos, Gerwyn Bish, Paul E Brennan, Mark E Bunnage, Andrew S Cook

J Med Chem· November 2012

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Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.
Julian Blagg, Charlotte M N Allerton, David V J Batchelor, Andrew D Baxter, Denise J Burring, Andrew S Cook

Bioorg Med Chem Lett· December 2007

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Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder.
David C Pryde, Andrew S Cook, Denise J Burring, Lyn H Jones, Stephanie Foll

Bioorg Med Chem· January 2007

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