Publications by authors named "Andy Billinton"

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Profile of NT-0527, a brain penetrant NLRP3 Inflammasome inhibitor suitable as an tool compound for neuroinflammatory disorders.
David Harrison, Andy Billinton, Mark G Bock, Nicholas P Clarke, Zsofia Digby

RSC Med Chem· September 2025

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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients.
Christopher Lloyd, Per-Ola Freskgård, Philip Newton, David Lowne, Adrian Nickson, Andy Billinton

Alzheimers Dement· November 2024

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Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1-pyrazol-4-yl)({[(2)-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework.
John R Doedens, Pamela Smolak, MyTrang Nguyen, Heather Wescott, Christine Diamond, Andy Billinton

ACS Pharmacol Transl Sci· May 2024

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Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders.
David Harrison, Andy Billinton, Mark G Bock, John R Doedens, Christopher A Gabel

J Med Chem· November 2023

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Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation .
Tomas Ondrejcak, Igor Klyubin, Neng-Wei Hu, Tiernan T O'Malley, Grant T Corbett, Andy Billinton

J Neurosci· August 2023

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Antibodies binding the head domain of P2X4 inhibit channel function and reverse neuropathic pain.
Wendy A Williams, John E Linley, Clare A Jones, Yoko Shibata, Arjan Snijder, Andy Billinton

Pain· September 2019

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Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP receptor partial agonist for the treatment of pain.
Mark P Healy, Amanda C Allan, Kristin Bailey, Andy Billinton, Iain P Chessell

Bioorg Med Chem Lett· June 2018

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Biologics: the next generation of analgesic drugs?
Iain P Chessell, Amanda Dudley, Andy Billinton

Drug Discov Today· August 2012

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Mechanistic differentiation of cancer pain: a pivotal role of P2X7 is absent.
Iain Chessell, Jon Hatcher, Andy Billinton

Pain· August 2011

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Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
Amanda C Allan, Andy Billinton, Susan H Brown, Anita Chowdhury, Andrew J Eatherton

Bioorg Med Chem Lett· July 2011

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.
Lee Abberley, Aude Bebius, Paul J Beswick, Andy Billinton, Katharine L Collis

Bioorg Med Chem Lett· November 2010

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Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Muna H Abdi, Paul J Beswick, Andy Billinton, Laura J Chambers, Andrew Charlton

Bioorg Med Chem Lett· September 2010

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Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.
Paul J Beswick, Andy Billinton, Laura J Chambers, David K Dean, Elena Fonfria

Bioorg Med Chem Lett· August 2010

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Human dental pulp as a source of native functional nociceptor pharmacology.
Andy Billinton

Pain· August 2009

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.
Adrian Hall, Andy Billinton, Susan H Brown, Anita Chowdhury, Nicholas M Clayton

Bioorg Med Chem Lett· May 2009

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The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain.
Penny C Staton, Jon P Hatcher, Deborah J Walker, Alastair D Morrison, Ellen M Shapland, Andy Billinton

Pain· September 2008

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Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain.
Stephen J Medhurst, Sue D Collins, Andy Billinton, Sharon Bingham, Robert G Dalziel

Pain· August 2008

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Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
Stephen J Medhurst, Jon P Hatcher, Christopher J Hille, Sharon Bingham, Nick M Clayton, Andy Billinton

J Pain· July 2008

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Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists.
Adrian Hall, Andy Billinton, Alan K Bristow, Susan H Brown, Anita Chowdhury

Bioorg Med Chem Lett· July 2008

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Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy.
Adrian Hall, Andy Billinton, Susan H Brown, Nicholas M Clayton, Anita Chowdhury

Bioorg Med Chem Lett· June 2008

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Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping.
Adrian Hall, Andy Billinton, Susan H Brown, Anita Chowdhury, Gerard M P Giblin

Bioorg Med Chem Lett· April 2008

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EP1 antagonists for the treatment of inflammatory pain.
Adrian Hall, Andy Billinton, Gerard M P Giblin

Curr Opin Drug Discov Devel· September 2007

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Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits.
Henry J Waldvogel, Andy Billinton, Julia H White, Piers C Emson, Richard L M Faull

J Comp Neurol· March 2004

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