Publications by authors named "Andy Zhu"

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Use of PopPK and E-R Analyses toward Explaining Causal Link Between ADAMTS13 in Recombinant vs. Plasma-Based Therapies and Clinical Effects in cTTP.
Munjal Patel, Huijuan Xu, Olivier Barriere, Paul Diderichsen, Parth Patwari, Andy Z X Zhu

Clin Pharmacol Ther· October 2025

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Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura.
Cameron McBride, Jiaolong Jiang, Zhiwei Zhang, John Tolsma, Parth Patwari, Andy Z X Zhu

CPT Pharmacometrics Syst Pharmacol· October 2025

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Personalized predictions of Glioblastoma infiltration: Mathematical models, Physics-Informed Neural Networks and multimodal scans.
Ray Zirui Zhang, Ivan Ezhov, Michal Balcerak, Andy Zhu, Benedikt Wiestler

Med Image Anal· April 2025

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TAK-994 mechanistic investigation into drug-induced liver injury.
Tadahiro Shinozawa, Kazumasa Miyamoto, Kevin S Baker, Samantha C Faber, Ramon Flores, Andy Z X Zhu

Toxicol Sci· April 2025

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A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema.
Dan Sexton, Hoa Q Nguyen, Salomé Juethner, Haobin Luo, Zhiwei Zhang, Andy Z X Zhu

J Pharmacokinet Pharmacodyn· December 2024

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Personalized Predictions of Glioblastoma Infiltration: Mathematical Models, Physics-Informed Neural Networks and Multimodal Scans.
Ray Zirui Zhang, Ivan Ezhov, Michal Balcerak, Andy Zhu, Benedikt Wiestler

ArXiv· August 2024

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Physician Posttraumatic Stress Disorder During COVID-19: A Systematic Review and Meta-Analysis.
Mihir Kamra, Shan Dhaliwal, Wenshan Li, Shrey Acharya, Adrian Wong, Andy Zhu

JAMA Netw Open· July 2024

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Leveraging a physiologically-based quantitative translational modeling platform for designing B cell maturation antigen-targeting bispecific T cell engagers for treatment of multiple myeloma.
Tomoki Yoneyama, Mi-Sook Kim, Konstantin Piatkov, Haiqing Wang, Andy Z X Zhu

PLoS Comput Biol· July 2022

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Does sex alter the relationship between CYP2B6 variation, hydroxybupropion concentration and bupropion-aided smoking cessation in African Americans? A moderated mediation analysis.
Meghan J Chenoweth, Annie R Peng, Andy Z X Zhu, Lisa Sanderson Cox, Nikki L Nollen

Addiction· June 2022

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Applications of Quantitative System Pharmacology Modeling to Model-Informed Drug Development.
Andy Z X Zhu, Mark Rogge

Methods Mol Biol· April 2022

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Functional characterization of novel rare CYP2A6 variants and potential implications for clinical outcomes.
Ahmed El-Boraie, Julie-Anne Tanner, Andy Z X Zhu, Katrina G Claw, Bhagwat Prasad

Clin Transl Sci· January 2022

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Physiologically-Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective.
Tycho Heimbach, Yuan Chen, Jun Chen, Vaishali Dixit, Neil Parrott, Andy Z X Zhu

Clin Pharmacol Ther· August 2021

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Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.
Vijayalakshmi Chelliah, Georgia Lazarou, Sumit Bhatnagar, John P Gibbs, Marjoleen Nijsen, Andy Z X Zhu

Clin Pharmacol Ther· March 2021

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Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Patient-derived Xenografts.
Adnan O Abu-Yousif, Donna Cvet, Melissa Gallery, Bret M Bannerman, Michelle L Ganno, Andy Zhu

Mol Cancer Ther· October 2020

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A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug-Drug Interactions of Bortezomib.
Shinji Iwasaki, Andy Zhu, Michael Hanley, Karthik Venkatakrishnan, Cindy Xia

AAPS J· April 2020

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A Minimal Physiologically-Based Pharmacokinetic Model Demonstrates Role of the Neonatal Fc Receptor (FcRn) Competition in Drug-Disease Interactions With Antibody Therapy.
Hussein M Abdallah, Andy Z X Zhu

Clin Pharmacol Ther· February 2020

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A Citrulline-Based Translational Population System Toxicology Model for Gastrointestinal-Related Adverse Events Associated With Anticancer Treatments.
Tomoki Yoneyama, Kojo Abdul-Hadi, Adam Brown, Emily Guan, Matt Wagoner, Andy Z X Zhu

CPT Pharmacometrics Syst Pharmacol· December 2019

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Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Shinji Iwasaki, Yohei Kosugi, Andy Z X Zhu, Sayaka Nakagawa, Noriyasu Sano

Xenobiotica· November 2019

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Overcoming Barriers to Hand Surgical Care in Low-Resource Settings.
Andy F Zhu, Terry R Light

Hand Clin· November 2019

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Recommendations for the Design of Clinical Drug-Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically-Based Pharmacokinetic Model.
Yuan Chen, Tamara D Cabalu, Ernesto Callegari, Heidi Einolf, Lichuan Liu, Andy Z X Zhu

CPT Pharmacometrics Syst Pharmacol· September 2019

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C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration.
Lois S Akinola, Bryan Mckiver, Wisam Toma, Andy Z X Zhu, Rachel F Tyndale

Brain Sci· September 2019

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Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Mingxiang Liao, Qing Zhu, Andy Zhu, Christopher Gemski, Bingli Ma

Xenobiotica· July 2019

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Survival Prolongation Index as a Novel Metric to Assess Anti-Tumor Activity in Xenograft Models.
Fiona Chandra, Lihi Zaks, Andy Zhu

AAPS J· January 2019

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The Role of Triangular Fibrocartilage Complex in Axial Stability of the Forearm.
Andy F Zhu, Geoffrey Burns, Breana Siljander, Jennifer F Waljee, Kagan Ozer

J Wrist Surg· November 2018

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The Effect of Axial Loading on Ulnar Variance.
Kagan Ozer, Andy F Zhu, Breana Siljander, Jeffrey N Lawton, Jennifer F Waljee

J Wrist Surg· July 2018

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