Publications by authors named "Angela Doran"

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Corrigendum to "Human cytochrome P4502C8 metabolizes repaglinide to 4'-hydroxyrepaglinide, not 3'-hydroxyrepaglinide" [Drug Metabolism and Disposition 53 (2025) 100177].
Raman Sharma, Amanda Balesano, Angela C Doran, Gregory S Walker, R Scott Obach

Drug Metab Dispos· December 2025

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Human cytochrome P4502C8 metabolizes repaglinide to 4'-hydroxyrepaglinide, not 3'-hydroxyrepaglinide.
Raman Sharma, Amanda Balesano, Angela C Doran, Gregory S Walker, R Scott Obach

Drug Metab Dispos· November 2025

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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Ritlecitinib, a Janus Kinase 3 and Tyrosine-Protein Kinase Family Inhibitor, in Humans.
Jonathan N Bauman, Angela C Doran, Gabrielle M Gualtieri, Brian Hee, Timothy Strelevitz

Drug Metab Dispos· September 2024

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The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite.
Martin E Dowty, Ruolun Qiu, Alyssa Dantonio, Mark Niosi, Angela Doran

Drug Metab Dispos· June 2024

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Physiologically Based Pharmacokinetic Modeling of the Drug-Drug Interaction Between CYP3A4 Substrate Glasdegib and Moderate CYP3A4 Inducers in Lieu of a Clinical Study.
Ernesto Callegari, Susanna Tse, Angela C Doran, Theunis C Goosen, Naveed Shaik

J Clin Pharmacol· January 2024

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Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT receptor occupancy from non-human primates to humans.
Aarti Sawant-Basak, Laigao Chen, Peter Lockwood, Tracey Boyden, Angela C Doran

Biopharm Drug Dispos· February 2023

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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans.
Jonathan N Bauman, Angela C Doran, Amanda King-Ahmad, Raman Sharma, Gregory S Walker

Drug Metab Dispos· August 2022

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An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach.
Angela C Doran, Alyssa L Dantonio, Gabrielle M Gualtieri, Amanda Balesano, Connor Landers

Drug Metab Dispos· July 2022

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Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Approach.
Angela C Doran, Woodrow Burchett, Connor Landers, Gabrielle M Gualtieri, Amanda Balesano

Drug Metab Dispos· July 2022

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Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping.
Alyssa L Dantonio, Angela C Doran, R Scott Obach

Drug Metab Dispos· March 2022

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Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacy.
Dae Wook Kim, Cheng Chang, Xian Chen, Angela C Doran, Francois Gaudreault

Mol Syst Biol· July 2019

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Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal Models.
Bo Feng, Angela C Doran, Li Di, Mark A West, Sarah M Osgood

J Pharm Sci· August 2018

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Metabolism of a 5HT Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction.
Aarti Sawant-Basak, R Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt

Drug Metab Dispos· July 2018

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Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors.
Travis T Wager, Paul Galatsis, Ramalakshmi Y Chandrasekaran, Todd W Butler, Jianke Li, Angela C Doran

ACS Chem Neurosci· September 2017

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Peripheral Administration of a Long-Acting Peptide Oxytocin Receptor Agonist Inhibits Fear-Induced Freezing.
Meera E Modi, Mark J Majchrzak, Kari R Fonseca, Angela Doran, Sarah Osgood

J Pharmacol Exp Ther· August 2016

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Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior.
Travis T Wager, Ramalakshmi Y Chandrasekaran, Jenifer Bradley, David Rubitski, Helen Berke, Angela Doran

ACS Chem Neurosci· December 2014

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Diphenhydramine has similar interspecies net active influx at the blood-brain barrier.
Christopher L Shaffer, Sarah M Osgood, Jessica Y Mancuso, Angela C Doran

J Pharm Sci· May 2014

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Ligand-protein interactions of selective casein kinase 1δ inhibitors.
Scot Mente, Eric Arnold, Todd Butler, Subramanyam Chakrapani, Ramalakshmi Chandrasekaran, Angela Doran

J Med Chem· September 2013

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An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.
Angela C Doran, Sarah M Osgood, Jessica Y Mancuso, Christopher L Shaffer

Drug Metab Dispos· November 2012

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Getting the MAX out of Computational Models: The Prediction of Unbound-Brain and Unbound-Plasma Maximum Concentrations.
Scot Mente, Angela Doran, Travis T Wager

ACS Med Chem Lett· June 2012

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Comparative analysis of the neurophysiological profile of group II metabotropic glutamate receptor activators and diazepam: effects on hippocampal and cortical EEG patterns in rats.
Chester J Siok, Shawn M Cogan, Lauren B Shifflett, Angela C Doran, Bernat Kocsis

Neuropharmacology· January 2012

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1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.
Lei Zhang, Michael A Brodney, John Candler, Angela C Doran, Allen J Duplantier

J Med Chem· March 2011

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Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.
Kevin M Walton, Katherine Fisher, David Rubitski, Michael Marconi, Qing-Jun Meng, Angela Doran

J Pharmacol Exp Ther· August 2009

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3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
Allen J Duplantier, Ivan Efremov, John Candler, Angela C Doran, Alan H Ganong

Bioorg Med Chem Lett· May 2009

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3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
Lei Zhang, Bruce N Rogers, Allen J Duplantier, Stanley F McHardy, Ivan Efremov, Angela C Doran

Bioorg Med Chem Lett· October 2008

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