Publications by authors named "Angela Styhler"

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Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.
David A Powell, W Cameron Black, Kelly Bleasby, Chi-Chung Chan, Denis Deschenes, Angela Styhler

Bioorg Med Chem Lett· December 2011

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Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.
Renata M Oballa, Liette Belair, W Cameron Black, Kelly Bleasby, Chi Chung Chan, Angela Styhler

J Med Chem· July 2011

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Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Michel Gallant, Renee Aspiotis, Stephen Day, Rebecca Dias, Daniel Dubé, Angela Styhler

Bioorg Med Chem Lett· November 2010

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The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.
Yves Ducharme, Marc Blouin, Christine Brideau, Anne Châteauneuf, Yves Gareau, Angela Styhler

ACS Med Chem Lett· July 2010

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A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors.
Lei Zhang, Yeeman Ramtohul, Sebastien Gagné, Angela Styhler, Hao Wang

J Biomol Screen· February 2010

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Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Patrick Lacombe, Nathalie Chauret, David Claveau, Stephen Day, Denis Deschênes, Angela Styhler

Bioorg Med Chem Lett· September 2009

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Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor.
Daniel Guay, Louise Boulet, Richard W Friesen, Mario Girard, Pierre Hamel, Angela Styhler

Bioorg Med Chem Lett· October 2008

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Design, synthesis, and biological evaluation of 8-biarylquinolines: a novel class of PDE4 inhibitors.
Michel Gallant, Nathalie Chauret, David Claveau, Stephen Day, Denis Deschênes, Angela Styhler

Bioorg Med Chem Lett· February 2008

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Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
Patrick Lacombe, Denis Deschênes, Daniel Dubé, Laurence Dubé, Michel Gallant, Angela Styhler

Bioorg Med Chem Lett· May 2006

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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor.
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Angela Styhler

Bioorg Med Chem Lett· December 2005

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Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
Denis Riendeau, Myriam Salem, Angela Styhler, Marc Ouellet, Joseph A Mancini

Bioorg Med Chem Lett· March 2004

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Substituted 2-pyridinemethanol derivatives as potent and selective phosphodiesterase-4 inhibitors.
Yves Ducharme, Richard W Friesen, Marc Blouin, Bernard Côté, Daniel Dubé, Angela Styhler

Bioorg Med Chem Lett· June 2003

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Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
Richard W Friesen, Yves Ducharme, Richard G Ball, Marc Blouin, Louise Boulet, Angela Styhler

J Med Chem· June 2003

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Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.
Bernard Côté, Richard Frenette, Sylvie Prescott, Marc Blouin, Christine Brideau, Angela Styhler

Bioorg Med Chem Lett· February 2003

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