Publications by authors named "Angus M Macleod"

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PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson's disease models.
Eduardo A Albornoz, Karine Mardon, Rajiv Bhalla, Vinod Kumar, Damion H R Stimson, Angus M MacLeod

Brain· October 2025

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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III.
Kumar N Alagramam, Suhasini R Gopal, Ruishuang Geng, Daniel H-C Chen, Ina Nemet, Angus M MacLeod

Nat Chem Biol· June 2016

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A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
Hilde M van der Schaar, Pieter Leyssen, Hendrik J Thibaut, Armando de Palma, Lonneke van der Linden, Angus M Macleod

Antimicrob Agents Chemother· October 2013

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Identification of a series of compounds with potent antiviral activity for the treatment of enterovirus infections.
Angus M MacLeod, Dale R Mitchell, Nicholas J Palmer, Hervé Van de Poël, Katja Conrath

ACS Med Chem Lett· July 2013

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Identification of an Orally Bioavailable, Potent, and Selective Inhibitor of GlyT1.
Wesley P Blackaby, Richard T Lewis, Joanne L Thomson, Andrew S R Jennings, Simon C Goodacre, Angus M MacLeod

ACS Med Chem Lett· October 2010

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Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders.
Tammy Ladduwahetty, Myra Gilligan, Alexander Humphries, Kevin J Merchant, Rebecca Fish, Angus M MacLeod

Bioorg Med Chem Lett· June 2010

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In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist.
John R Atack, Karen A Maubach, Keith A Wafford, Desmond O'Connor, A David Rodrigues, Angus M MacLeod

J Pharmacol Exp Ther· November 2009

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2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands.
Kevin J Wilson, Monique B van Niel, Laura Cooper, Dawn Bloomfield, Desmond O'Connor, Angus M MacLeod

Bioorg Med Chem Lett· May 2007

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A new class of selective, non-basic 5-HT2A receptor antagonists.
Tammy Ladduwahetty, Amanda L Boase, Andrew Mitchinson, Caroline Quin, Smita Patel, Angus M MacLeod

Bioorg Med Chem Lett· June 2006

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Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective GABA(A) alpha5 inverse agonist for cognitive dysfunction.
Philip Jones, John R Atack, Matthew P Braun, Brian P Cato, Mark S Chambers, Angus M MacLeod

Bioorg Med Chem Lett· February 2006

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A new pyridazine series of GABAA alpha5 ligands.
Monique B van Niel, Kevin Wilson, Charles H Adkins, John R Atack, José L Castro, Angus M MacLeod

J Med Chem· September 2005

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4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia.
L Rebecca Fish, Myra T Gilligan, Alexander C Humphries, Magnus Ivarsson, Tammy Ladduwahetty, Angus M MacLeod

Bioorg Med Chem Lett· August 2005

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An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.
Mark S Chambers, John R Atack, Robert W Carling, Neil Collinson, Susan M Cook, Angus M Macleod

J Med Chem· November 2004

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Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.
Leslie J Street, Francine Sternfeld, Richard A Jelley, Austin J Reeve, Robert W Carling, Angus M MacLeod

J Med Chem· July 2004

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3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors.
Helen J Szekeres, John R Atack, Mark S Chambers, Susan M Cook, Alison J Macaulay, Angus M MacLeod

Bioorg Med Chem Lett· June 2004

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Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.
Francine Sternfeld, Robert W Carling, Richard A Jelley, Tamara Ladduwahetty, Kevin J Merchant, Angus M MacLeod

J Med Chem· April 2004

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Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.
Mark S Chambers, John R Atack, Howard B Broughton, Neil Collinson, Susan Cook, Angus M MacLeod

J Med Chem· May 2003

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6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.
Mark S Chambers, John R Atack, Frances A Bromidge, Howard B Broughton, Susan Cook, Angus M MacLeod

J Med Chem· March 2002

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4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Stephen R Fletcher, Frank Burkamp, Peter Blurton, Susan K F Cheng, Robert Clarkson, Angus M MacLeod

J Med Chem· January 2002

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