Publications by authors named "Angus Nedderman"

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No Clinical Impact of CYP3A5 Gene Polymorphisms on the Pharmacokinetics and/or Efficacy of Maraviroc in Healthy Volunteers and HIV-1-Infected Subjects.
Manoli Vourvahis, Lynn McFadyen, Sunil Nepal, Srinivas Rao Valluri, Annie Fang, Angus Nedderman

J Clin Pharmacol· January 2019

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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Simone Schadt, Bojan Bister, Swapan K Chowdhury, Christoph Funk, Cornelis E C A Hop, Angus N R Nedderman

Drug Metab Dispos· June 2018

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The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
Sarah E Skerratt, Mark Andrews, Sharan K Bagal, James Bilsland, David Brown, Angus Nedderman

J Med Chem· November 2016

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Simultaneous qualitative and quantitative metabolism data generation: a convenient marriage?
Angus N R Nedderman, Mark E Savage, Michelle Gleave, Julian J Haynes

Bioanalysis· May 2012

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Radiolabelled mass-balance excretion and metabolism studies in laboratory animals: are they still necessary?
R Scott Obach, Angus N Nedderman, Dennis A Smith

Xenobiotica· January 2012

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The use of accelerator MS in support of MIST.
Angus Nedderman

Bioanalysis· December 2011

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From definition to implementation: a cross-industry perspective of past, current and future MIST strategies.
Angus N R Nedderman, Gordon J Dear, Stephanie North, R Scott Obach, David Higton

Xenobiotica· August 2011

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Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis.
Angus N R Nedderman, Pat Wright

Bioanalysis· July 2010

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Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers.
Manoli Vourvahis, Michelle Gleave, Angus N R Nedderman, Ruth Hyland, Iain Gardner

Drug Metab Dispos· May 2010

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A holistic strategy for characterizing the safety of metabolites through drug discovery and development.
Don Walker, Joe Brady, Deepak Dalvie, John Davis, Martin Dowty, Angus Nedderman

Chem Res Toxicol· October 2009

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Metabolites in safety testing: metabolite identification strategies in discovery and development.
Angus N R Nedderman

Biopharm Drug Dispos· May 2009

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Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
Deepak Dalvie, R Scott Obach, Ping Kang, Chandra Prakash, Cho-Ming Loi, Angus Nedderman

Chem Res Toxicol· February 2009

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In vitro screening techniques for reactive metabolites for minimizing bioactivation potential in drug discovery.
Chandra Prakash, Raman Sharma, Michelle Gleave, Angus Nedderman

Curr Drug Metab· November 2008

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Assessment of the absorption, metabolism and absolute bioavailability of maraviroc in healthy male subjects.
Samantha Abel, Deborah Russell, Lyndsey A Whitlock, Caroline E Ridgway, Angus N R Nedderman

Br J Clin Pharmacol· April 2008

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Analytical strategies for identifying drug metabolites.
Chandra Prakash, Christopher L Shaffer, Angus Nedderman

Mass Spectrom Rev· June 2007

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Species differences in the disposition of the CCR5 antagonist, UK-427,857, a new potential treatment for HIV.
Don K Walker, Samantha Abel, Pierre Comby, Gary J Muirhead, Angus N R Nedderman

Drug Metab Dispos· April 2005

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The use of 96-well Scintiplates to facilitate definitive metabolism studies for drug candidates.
Angus N R Nedderman, Mark E Savage, Katharine L White, Donald K Walker

J Pharm Biomed Anal· February 2004

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