Publications by authors named "Anna Tochowicz"

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Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain.
Brian D Jones, Anna Tochowicz, Yinyan Tang, Michael D Cameron, Laura-Isobel McCall

ACS Med Chem Lett· January 2016

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Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
Outi M H Salo-Ahen, Anna Tochowicz, Cecilia Pozzi, Daniela Cardinale, Stefania Ferrari

J Med Chem· April 2015

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Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides.
Anna Tochowicz, Matteo Santucci, Puneet Saxena, Giambattista Guaitoli, Matteo Trande

J Med Chem· January 2015

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Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.
Anna Tochowicz, Sean Dalziel, Oliv Eidam, Joseph D O'Connell, Sarah Griner

J Med Chem· July 2013

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Optimization of peptidyl allyl sulfones as clan CA cysteine protease inhibitors.
Brandon D Fennell, Julia M Warren, Kevin K Chung, Hannah L Main, Andrew B Arend, Anna Tochowicz

J Enzyme Inhib Med Chem· June 2013

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Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
Emanuele Carosati, Anna Tochowicz, Gaetano Marverti, Giambattista Guaitoli, Paolo Benedetti

J Med Chem· November 2012

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The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions.
Anna Tochowicz, Peter Goettig, Richard Evans, Robert Visse, Yasuyuki Shitomi

J Biol Chem· March 2011

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Crystal structures of MMP-9 complexes with five inhibitors: contribution of the flexible Arg424 side-chain to selectivity.
Anna Tochowicz, Klaus Maskos, Robert Huber, Ruth Oltenfreiter, Vincent Dive

J Mol Biol· August 2007

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