Publications by authors named "Anthony Leone"

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Integrated SegFlow, µSIA, and UPLC for Online Sialic Acid Quantitation of Glycoproteins Directly from Bioreactors.
Letha Chemmalil, Tanmay Kulkarni, Mathura Raman, Priya Singh, Yueming Qian, Anthony Leone

Eng Life Sci· January 2025

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Rapid total sialic acid monitoring during cell culture process using a machine learning model based soft sensor.
Amir M Behdani, Yuxiang Zhao, Grace Yao, Dhanuka Wasalathanthri, Eric Hodgman, Anthony Leone

Biotechnol Prog· December 2024

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Enabling Efficient Design of Biological Formulations through Advanced Characterizations.
Kang Chen, Jason K Cheung, Hai-Young Anne Kim, Anthony Leone, Krishna Mallela

Pharm Res· June 2023

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Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study.
Trina Mouchahoir, John E Schiel, Rich Rogers, Alan Heckert, Benjamin J Place, Anthony M Leone

J Am Soc Mass Spectrom· September 2022

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Industry White Paper: Contemporary Opportunities and Challenges in Characterizing Crystallinity in Amorphous Solid Dispersions.
Tyson Chasse, Stephen L Conway, Gerald D Danzer, Lili Feng, Anthony M Leone

J Pharm Sci· June 2022

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Process analytics 4.0: A paradigm shift in rapid analytics for biologics development.
Dhanuka P Wasalathanthri, Ruchir Shah, Julia Ding, Anthony Leone, Zheng Jian Li

Biotechnol Prog· July 2021

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New Peak Detection Performance Metrics from the MAM Consortium Interlaboratory Study.
Trina Mouchahoir, John E Schiel, Rich Rogers, Alan Heckert, Benjamin J Place, Anthony M Leone

J Am Soc Mass Spectrom· April 2021

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Enhancing Host-Cell Protein Detection in Protein Therapeutics Using HILIC Enrichment and Proteomic Analysis.
Qingyi Wang, Thomas R Slaney, Wei Wu, Richard Ludwig, Li Tao, Anthony Leone

Anal Chem· August 2020

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Unique Impacts of Methionine Oxidation, Tryptophan Oxidation, and Asparagine Deamidation on Antibody Stability and Aggregation.
Magfur E Alam, Thomas R Slaney, Lina Wu, Tapan K Das, Sambit Kar, Anthony Leone

J Pharm Sci· January 2020

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Mechanism and Impact of Excipient Incompatibility: Cross-Linking of Xanthan Gum in Pediatric Powder-for-Suspension Formulations.
Yongjun Li, Dan Zhang, Jason Ash, Xiujuan Jia, Anthony Leone

J Pharm Sci· November 2019

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Probing the Tryptophan Environment in Therapeutic Proteins: Implications for Higher Order Structure on Tryptophan Oxidation.
Gregory V Barnett, Gurusamy Balakrishnan, Naresh Chennamsetty, Laurel Hoffman, Jacob Bongers, Anthony Leone

J Pharm Sci· June 2019

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Subunit mass analysis for monitoring multiple attributes of monoclonal antibodies.
Peiran Liu, Xin Zhu, Wei Wu, Richard Ludwig, Hangtian Song, Anthony M Leone

Rapid Commun Mass Spectrom· January 2019

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Impact of Tryptophan Oxidation in Complementarity-Determining Regions of Two Monoclonal Antibodies on Structure-Function Characterized by Hydrogen-Deuterium Exchange Mass Spectrometry and Surface Plasmon Resonance.
Tyler Hageman, Hui Wei, Patrick Kuehne, Jinmei Fu, Richard Ludwig, Anthony Leone

Pharm Res· December 2018

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Enhanced Precision of Circular Dichroism Spectral Measurements Permits Detection of Subtle Higher Order Structural Changes in Therapeutic Proteins.
Gregory V Barnett, Gurusamy Balakrishnan, Naresh Chennamsetty, Brent Meengs, Jeffery Meyer, Anthony Leone

J Pharm Sci· October 2018

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In Situ Characterization of Pharmaceutical Formulations by Dynamic Nuclear Polarization Enhanced MAS NMR.
Qing Zhe Ni, Fengyuan Yang, Thach V Can, Ivan V Sergeyev, Suzanne M D'Addio, Anthony Leone

J Phys Chem B· August 2017

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Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions.
Haichen Nie, Yongchao Su, Mingtao Zhang, Yang Song, Anthony Leone

Mol Pharm· November 2016

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New and Evolving Techniques for the Characterization of Peptide Therapeutics.
Suzanne M D'Addio, Jameson R Bothe, Claudia Neri, Paul L Walsh, Jingtao Zhang, Anthony Leone

J Pharm Sci· October 2016

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Rheology Guided Rational Selection of Processing Temperature To Prepare Copovidone-Nifedipine Amorphous Solid Dispersions via Hot Melt Extrusion (HME).
Fengyuan Yang, Yongchao Su, Jingtao Zhang, James DiNunzio, Anthony Leone

Mol Pharm· October 2016

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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
Stephanie E Barrett, Rob S Burke, Marc T Abrams, Carol Bason, Marina Busuek, Anthony M Leone

J Control Release· June 2014

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An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents.
Stephanie E Barrett, Marc T Abrams, Rob Burke, Brian A Carr, Louis S Crocker, Anthony M Leone

Int J Pharm· May 2014

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Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates.
Rubina Giare Parmar, Micheal Poslusney, Marina Busuek, J Michael Williams, Robert Garbaccio, Anthony Leone

Bioconjug Chem· May 2014

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Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness.
Erin N Guidry, Julie Farand, Arash Soheili, Craig A Parish, Nancy J Kevin, Anthony Leone

Bioconjug Chem· February 2014

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The development of an in vitro assay to screen lipid based nanoparticles for siRNA delivery.
Ye Zhang, Leticia Arrington, David Boardman, Jared Davis, Yan Xu, Anthony Leone

J Control Release· January 2014

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Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics.
Rubina Giare Parmar, Marina Busuek, Eileen S Walsh, Karen R Leander, Bonnie J Howell, Anthony Leone

Bioconjug Chem· April 2013

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Assessing the heterogeneity level in lipid nanoparticles for siRNA delivery: size-based separation, compositional heterogeneity, and impact on bioperformance.
Jingtao Zhang, Yi Pei, Hangchun Zhang, Lei Wang, Leticia Arrington, Anthony M Leone

Mol Pharm· January 2013

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