Publications by authors named "Marc T Abrams"

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RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade.
Shanthi Ganesh, Xue Shui, Kevin P Craig, Jihye Park, Weimin Wang, Marc T Abrams

Mol Ther· November 2018

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β-Catenin mRNA Silencing and MEK Inhibition Display Synergistic Efficacy in Preclinical Tumor Models.
Shanthi Ganesh, Xue Shui, Kevin P Craig, Martin L Koser, Girish R Chopda, Marc T Abrams

Mol Cancer Ther· February 2018

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Direct Pharmacological Inhibition of β-Catenin by RNA Interference in Tumors of Diverse Origin.
Shanthi Ganesh, Martin L Koser, Wendy A Cyr, Girish R Chopda, Junyan Tao, Marc T Abrams

Mol Cancer Ther· September 2016

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A single dose of EGLN1 siRNA yields increased erythropoiesis in nonhuman primates.
Marc T Abrams, Martin Koser, Julja Burchard, Walter Strapps, Huseyin Mehmet

Nucleic Acid Ther· December 2014

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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
Stephanie E Barrett, Rob S Burke, Marc T Abrams, Carol Bason, Marina Busuek

J Control Release· June 2014

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An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents.
Stephanie E Barrett, Marc T Abrams, Rob Burke, Brian A Carr, Louis S Crocker

Int J Pharm· May 2014

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Quantitative evaluation of siRNA delivery in vivo.
Yi Pei, Paula J Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Marc T Abrams

RNA· December 2010

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Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment.
Marc T Abrams, Martin L Koser, Jessica Seitzer, Stephanie C Williams, Martha A DiPietro

Mol Ther· January 2010

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Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Antonella Converso, Timothy Hartingh, Robert M Garbaccio, Edward Tasber, Keith Rickert, Marc T Abrams

Bioorg Med Chem Lett· February 2009

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Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
Christopher D Cox, Paul J Coleman, Michael J Breslin, David B Whitman, Robert M Garbaccio, Marc T Abrams

J Med Chem· July 2008

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Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Robert M Garbaccio, Shaei Huang, Edward S Tasber, Mark E Fraley, Youwei Yan, Marc T Abrams

Bioorg Med Chem Lett· November 2007

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Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Christopher D Cox, Michael J Breslin, David B Whitman, Paul J Coleman, Robert M Garbaccio, Marc T Abrams

Bioorg Med Chem Lett· May 2007

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RNAi-mediated silencing of insulin receptor substrate 1 (IRS-1) enhances tamoxifen-induced cell death in MCF-7 breast cancer cells.
Gregory Cesarone, Cecilia Garofalo, Marc T Abrams, Olga Igoucheva, Vitali Alexeev

J Cell Biochem· May 2006

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EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities.
Marlene R Quadros, Sharon Connelly, Csaba Kari, Marc T Abrams, Eric Wickstrom

Cancer Biol Ther· May 2006

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Evaluation of glucocorticoid sensitivity in 697 pre-B acute lymphoblastic leukemia cells after overexpression or silencing of MAP kinase phosphatase-1.
Marc T Abrams, Noreen M Robertson, Gerald Litwack, Eric Wickstrom

J Cancer Res Clin Oncol· June 2005

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Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA.
Marc T Abrams, Noreen M Robertson, Kyonggeun Yoon, Eric Wickstrom

J Biol Chem· December 2004

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Macrocyclic piperazinones as potent dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.
Christopher J Dinsmore, C Blair Zartman, Jeffrey M Bergman, Marc T Abrams, Carolyn A Buser

Bioorg Med Chem Lett· February 2004

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Role of apical caspases and glucocorticoid-regulated genes in glucocorticoid-induced apoptosis of pre-B leukemic cells.
Sonia L Planey, Marc T Abrams, Noreen M Robertson, Gerald Litwack

Cancer Res· January 2003

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The synthesis and biological evaluation of a series of potent dual inhibitors of farnesyl and geranyl-Geranyl protein transferases.
Thomas J Tucker, Marc T Abrams, Carolyn A Buser, Joseph P Davide, Michelle Ellis-Hutchings

Bioorg Med Chem Lett· August 2002

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