Publications by authors named "Walter Strapps"

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A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing.
Jonathan D Finn, Amy Rhoden Smith, Mihir C Patel, Lucinda Shaw, Madeleine R Youniss, Walter R Strapps

Cell Rep· February 2018

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Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing.
Wonsuk Chang, Yi Pei, Erin N Guidry, Daniel Zewge, Craig A Parish, Walter R Strapps

Bioorg Med Chem Lett· September 2016

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Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth.
Tayeba Khan, Hans Weber, Jillian DiMuzio, Andrea Matter, Belma Dogdas, Walter R Strapps, Marija Tadin-Strapps

Mol Ther Nucleic Acids· August 2016

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5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.
Rubina Parmar, Jennifer L S Willoughby, Jingxuan Liu, Donald J Foster, Benjamin Brigham, Walter Strapps

Chembiochem· June 2016

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Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target.
Wendy Ankrom, Harold B Wood, Jiayi Xu, Wayne Geissler, Tom Bateman, Walter R Strapps, Marija Tadin-Strapps

Pharmacol Res Perspect· February 2016

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Factor XII full and partial null in rat confers robust antithrombotic efficacy with no bleeding.
Tian-Quan Cai, Weizhen Wu, Myung K Shin, Yiming Xu, Nina Jochnowitz, Walter Strapps, Marija Tadin-Strapps

Blood Coagul Fibrinolysis· December 2015

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Alterations in the hepatic transcriptional landscape after RNAi mediated ApoB silencing in cynomolgus monkeys.
M Sabry Hamza, Chanchal Kumar, Ser Mien Chia, Vidhya Anandalakshmi, Nicole Boo, Walter Strapps, Marija Tadin-Strapps

Atherosclerosis· October 2015

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Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability.
Joseph M Metzger, Marija Tadin-Strapps, Anil Thankappan, Walter R Strapps, Marti DiPietro

Thromb Haemost· June 2015

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Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit.
Zhu Chen, Bin Luo, Tian-Quan Cai, Anil Thankappan, Yiming Xu, Walter Strapps, Marija Tadin-Strapps

Mol Ther Nucleic Acids· January 2015

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siRNA-mediated knockdown of P450 oxidoreductase in rats: a tool to reduce metabolism by CYPs and increase exposure of high clearance compounds.
Rob S Burke, Inthirai Somasuntharam, Paul Rearden, Duncan Brown, Sujal V Deshmukh, Walter R Strapps

Pharm Res· December 2014

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A single dose of EGLN1 siRNA yields increased erythropoiesis in nonhuman primates.
Marc T Abrams, Martin Koser, Julja Burchard, Walter Strapps, Huseyin Mehmet

Nucleic Acid Ther· December 2014

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Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice.
Seongah Han, Taro E Akiyama, Stephen F Previs, Kithsiri Herath, Thomas P Roddy, Walter Strapps

J Lipid Res· October 2013

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Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis.
Kenneth L Clark, Stephen A Hughes, Pallav Bulsara, Jill Coates, Kitty Moores, Walter R Strapps

Mol Ther Nucleic Acids· January 2013

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siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids.
Marija Tadin-Strapps, Laurence B Peterson, Anne-Marie Cumiskey, Raymond L Rosa, Vivienne Halili Mendoza, Walter R Strapps

J Lipid Res· June 2011

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The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.
Walter R Strapps, Victoria Pickering, Gladys T Muiru, Julie Rice, Stacey Orsborn

Nucleic Acids Res· August 2010

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The genetic design of signaling cascades to record receptor activation.
Gilad Barnea, Walter Strapps, Gilles Herrada, Yemiliya Berman, Jane Ong

Proc Natl Acad Sci U S A· January 2008

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Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless.
Chiann-Mun Chen, Walter Strapps, Andrew Tomlinson, Gary Struhl

Proc Natl Acad Sci U S A· November 2004

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