Publications by authors named "April D Lake"

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Discovery of Hepatitis B Virus Surface Antigen Suppressor GS-8873.
Darryl Kato, Regina Wai-Yan Choy, Eda Canales, Ryan A Dick, April D Lake

ACS Med Chem Lett· April 2024

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Neurotoxicity of an Hepatitis B Virus (HBV) Transcript Inhibitor in 13-Week Rat and Monkey Studies.
April D Lake, Kevin Holsapple, Tanya McDonnell, Joseph C Arezzo, Ricardo Ramirez

Toxicol Sci· March 2022

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Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.
April D Lake, Rhiannon N Hardwick, Christopher P Leamon, Philip S Low, Nathan J Cherrington

Toxicol Appl Pharmacol· April 2019

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Impaired N-linked glycosylation of uptake and efflux transporters in human non-alcoholic fatty liver disease.
John D Clarke, Petr Novak, April D Lake, Rhiannon N Hardwick, Nathan J Cherrington

Liver Int· July 2017

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Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model.
JianHua Han, Anika L Dzierlenga, Zhengqiang Lu, Dean D Billheimer, Elmira Torabzadeh, April D Lake

Obesity (Silver Spring)· June 2017

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Transcription factor binding site enrichment analysis predicts drivers of altered gene expression in nonalcoholic steatohepatitis.
April D Lake, Alexandria L Chaput, Petr Novak, Nathan J Cherrington, Catharine L Smith

Biochem Pharmacol· December 2016

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Dose and Effect Thresholds for Early Key Events in a PPARα-Mediated Mode of Action.
April D Lake, Charles E Wood, Virunya S Bhat, Brian N Chorley, Gleta K Carswell

Toxicol Sci· February 2016

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Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice.
Charles E Wood, Susan D Hester, Brian N Chorley, Gleta Carswell, Michael H George, April D Lake

Carcinogenesis· July 2015

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Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.
April D Lake, Petr Novak, Petia Shipkova, Nelly Aranibar, Donald G Robertson

Amino Acids· March 2015

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Renal xenobiotic transporter expression is altered in multiple experimental models of nonalcoholic steatohepatitis.
Mark J Canet, Rhiannon N Hardwick, April D Lake, Anika L Dzierlenga, John D Clarke

Drug Metab Dispos· February 2015

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Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.
Rhiannon N Hardwick, John D Clarke, April D Lake, Mark J Canet, Tarun Anumol

Toxicol Sci· November 2014

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Synergistic interaction between genetics and disease on pravastatin disposition.
John D Clarke, Rhiannon N Hardwick, April D Lake, Andrew J Lickteig, Michael J Goedken

J Hepatol· July 2014

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Circulating microRNA 122 in the methionine and choline-deficient mouse model of non-alcoholic steatohepatitis.
John D Clarke, Tatiana Sharapova, April D Lake, Eric Blomme, Jonathan Maher

J Appl Toxicol· June 2014

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Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.
Mark J Canet, Rhiannon N Hardwick, April D Lake, Anika L Dzierlenga, John D Clarke

Drug Metab Dispos· April 2014

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Experimental nonalcoholic steatohepatitis increases exposure to simvastatin hydroxy acid by decreasing hepatic organic anion transporting polypeptide expression.
John D Clarke, Rhiannon N Hardwick, April D Lake, Mark J Canet, Nathan J Cherrington

J Pharmacol Exp Ther· March 2014

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Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.
John D Clarke, Petr Novak, April D Lake, Petia Shipkova, Nelly Aranibar

Dig Dis Sci· February 2014

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The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease.
April D Lake, Petr Novak, Rhiannon N Hardwick, Brieanna Flores-Keown, Fei Zhao

Toxicol Sci· January 2014

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Differential regulation of hepatic organic cation transporter 1, organic anion-transporting polypeptide 1a4, bile-salt export pump, and multidrug resistance-associated protein 2 transporter expression in lymphocyte-deficient mice associates with interleukin-6 production.
Connor E Bodeman, Anika L Dzierlenga, Catherine M Tally, Ryan M Mulligan, April D Lake

J Pharmacol Exp Ther· October 2013

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Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.
April D Lake, Petr Novak, Petia Shipkova, Nelly Aranibar, Donald Robertson

Toxicol Appl Pharmacol· April 2013

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Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.
Rhiannon N Hardwick, Daniel W Ferreira, Vijay R More, April D Lake, Zhenqiang Lu

Drug Metab Dispos· March 2013

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Altered arsenic disposition in experimental nonalcoholic fatty liver disease.
Mark J Canet, Rhiannon N Hardwick, April D Lake, Michael J Kopplin, George L Scheffer

Drug Metab Dispos· September 2012

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Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease.
April D Lake, Petr Novak, Craig D Fisher, Jonathan P Jackson, Rhiannon N Hardwick

Drug Metab Dispos· October 2011

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Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease.
Rhiannon N Hardwick, Craig D Fisher, Mark J Canet, April D Lake, Nathan J Cherrington

Drug Metab Dispos· December 2010

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Development of high-yield autofluorescent protein microarrays using hybrid cell-free expression with combined Escherichia coli S30 and wheat germ extracts.
Xristo Zárate, David C Henderson, Keenan C Phillips, April D Lake, David W Galbraith

Proteome Sci· June 2010

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