Publications by authors named "Ari Firestone"

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Loss of UXS1 Selectively Depletes Pyrimidines and Induces Replication Stress in KEAP1-Mutant Lung Cancer.
Melat T Gebru, Timothy E Hoffman, Aaron Boudreau, Ngoc Vu, Fei Han, Ari J Firestone

Cancer Res· December 2025

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Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen.
Yunsong Tong, Kenton A Baker, Alex M Chapman, Nathaniel L Elsen, Faith Fowler, Ari J Firestone

J Med Chem· June 2025

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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint.
Hsiao-Wei Tsao, Seth Anderson, Kenneth J Finn, Jonathan J Perera, Lomax F Pass, Ari Firestone

Immunity· December 2024

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Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I.
Lisa Choy, Stephen Norris, Xiumin Wu, Ganesh Kolumam, Ari Firestone

Cancer Res Commun· February 2024

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Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis .
John T Randolph, Matthew J O'Connor, Fei Han, Charles W Hutchins, Y Amy Siu, Ari J Firestone

J Med Chem· March 2023

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Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation.
Radu M Suciu, Irungu K Luvaga, Akram Hazeen, Chulangani Weerasooriya, Stewart K Richardson, Ari J Firestone

Bioorg Med Chem Lett· December 2021

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ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth.
Jarrett R Remsberg, Radu M Suciu, Noemi A Zambetti, Thomas W Hanigan, Ari J Firestone

Nat Chem Biol· August 2021

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Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Noemi A Zambetti, Ari J Firestone, Jarrett R Remsberg, Benjamin J Huang, Jasmine C Wong

Blood· May 2020

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Rita Sulahian, Jason J Kwon, Katherine H Walsh, Emma Pailler, Timothy L Bosse, Ari J Firestone

Cell Rep· October 2019

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Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
Matthew F Pech, Linda E Fong, Jacqueline E Villalta, Leanne Jg Chan, Samir Kharbanda, Ari J Firestone

Elife· August 2019

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A three-drug combination to treat BRAF-mutant cancers.
Ari J Firestone, Jeff Settleman

Nat Med· August 2017

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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
Michael R Burgess, Eugene Hwang, Rana Mroue, Craig M Bielski, Anica M Wandler, Ari J Firestone

Cell· February 2017

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KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
Yasmine White, Aditi Bagchi, Jessica Van Ziffle, Anagha Inguva, Gideon Bollag, Ari J Firestone

Nat Commun· February 2016

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KRAS Engages AGO2 to Enhance Cellular Transformation.
Sunita Shankar, Sethuramasundaram Pitchiaya, Rohit Malik, Vishal Kothari, Yasuyuki Hosono, Ari Firestone

Cell Rep· February 2016

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Correction: Monoallelic Loss of the Imprinted Gene Grb10 Promotes Tumor Formation in Irradiated Nf1+/- Mice.
Rana Mroue, Brian Huang, Steve Braunstein, Ari J Firestone, Jean L Nakamura

PLoS Genet· June 2015

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Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
Rana Mroue, Brian Huang, Steve Braunstein, Ari J Firestone, Jean L Nakamura

PLoS Genet· May 2015

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Preclinical efficacy of MEK inhibition in Nras-mutant AML.
Michael R Burgess, Eugene Hwang, Ari J Firestone, Tannie Huang, Jin Xu

Blood· December 2014

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Arhgap36-dependent activation of Gli transcription factors.
Paul G Rack, Jun Ni, Alexander Y Payumo, Vien Nguyen, J Aaron Crapster, Ari J Firestone

Proc Natl Acad Sci U S A· July 2014

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Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.
Jin Xu, Kevin M Haigis, Ari J Firestone, Megan E McNerney, Qing Li

Cancer Discov· September 2013

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Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Ari J Firestone, Joshua S Weinger, Maria Maldonado, Kari Barlan, Lance D Langston

Nature· March 2012

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Controlling destiny through chemistry: small-molecule regulators of cell fate.
Ari J Firestone, James K Chen

ACS Chem Biol· January 2010

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Joel M Hyman, Ari J Firestone, Vivi M Heine, Yun Zhao, Cory A Ocasio

Proc Natl Acad Sci U S A· August 2009

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The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.
Tommaso Cupido, Paul G Rack, Ari J Firestone, Joel M Hyman, Kyuho Han

Angew Chem Int Ed Engl· April 2009

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Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.
John K Mich, Heiko Blaser, Natalie A Thomas, Ari J Firestone, Deborah Yelon

Dev Biol· April 2009

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Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis.
Shawn F Bairstow, Kun Ling, Xiaojing Su, Ari J Firestone, Chateen Carbonara

J Biol Chem· July 2006

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