Publications by authors named "Jeff Settleman"

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Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors.
Tan-Min Chin, Gandhi T K Boopathy, Ellen P S Man, John G Clohessy, Eva Csizmadia, Jeff Settleman

Theranostics· May 2021

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Thinking Differently about Cancer Treatment Regimens.
Jeff Settleman, João M Fernandes Neto, René Bernards

Cancer Discov· May 2021

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Emerging Trends in Cancer Drug Discovery-From Drugging the "Undruggable" to Overcoming Resistance.
Joachim Rudolph, Jeff Settleman, Shiva Malek

Cancer Discov· April 2021

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A gene expression signature associated with ''K-Ras addiction'' reveals regulators of EMT and tumor cell survival.
Anurag Singh, Patricia Greninger, Daniel Rhodes, Louise Koopman, Sheila Violette, Jeff Settleman

Cancer Cell· March 2021

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Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein.
Marian M Deuker, Kaitlyn N Lewis, Maria Ingaramo, Jacob Kimmel, Rochelle Buffenstein, Jeff Settleman

Sci Rep· April 2020

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A Single-Step, High-Dose Selection Scheme Reveals Distinct Mechanisms of Acquired Resistance to Oncogenic Kinase Inhibition in Cancer Cells.
Kenneth J Finn, Scott E Martin, Jeff Settleman

Cancer Res· January 2020

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Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation.
Victoria E Wang, Jenny Y Xue, Dennie T Frederick, Yi Cao, Eva Lin, Jeff Settleman

Clin Cancer Res· December 2019

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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.
Rita Sulahian, Jason J Kwon, Katherine H Walsh, Emma Pailler, Timothy L Bosse, Jeff Settleman

Cell Rep· October 2019

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Cotargeting of MEK and PDGFR/STAT3 Pathways to Treat Pancreatic Ductal Adenocarcinoma.
Nisebita Sahu, Emily Chan, Felix Chu, Thinh Pham, Hartmut Koeppen, Jeff Settleman

Mol Cancer Ther· September 2017

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Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in mutant mesenchymal-like NSCLC cells.
Anita K Mehta, Kevin Hua, William Whipple, Minh-Thuy Nguyen, Ching-Ti Liu, Jeff Settleman

Sci Signal· September 2017

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A three-drug combination to treat BRAF-mutant cancers.
Ari J Firestone, Jeff Settleman

Nat Med· August 2017

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Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure.
Gulfem Dilek Guler, Charles Albert Tindell, Robert Pitti, Catherine Wilson, Katrina Nichols, Jeff Settleman

Cancer Cell· August 2017

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Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells.
Ho-June Lee, Yi Cao, Victoria Pham, Elizabeth Blackwood, Catherine Wilson, Jeff Settleman

Mol Cancer Ther· April 2017

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Proline Starvation Induces Unresolved ER Stress and Hinders mTORC1-Dependent Tumorigenesis.
Nisebita Sahu, Darlene Dela Cruz, Min Gao, Wendy Sandoval, Peter M Haverty, Jeff Settleman

Cell Metab· November 2016

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TORquing metabolic reprogramming in cancer cells.
Raju Pusapati, Jeff Settleman

Cell Cycle· September 2016

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Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.
Nisebita Sahu, Jean-Philippe Stephan, Darlene Dela Cruz, Mark Merchant, Benjamin Haley, Jeff Settleman

Nat Commun· August 2016

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Reproducible pharmacogenomic profiling of cancer cell line panels.
Peter M Haverty, Eva Lin, Jenille Tan, Yihong Yu, Billy Lam, Jeff Settleman

Nature· May 2016

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mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells.
Raju V Pusapati, Anneleen Daemen, Catherine Wilson, Wendy Sandoval, Min Gao, Jeff Settleman

Cancer Cell· April 2016

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Communication in Drug Development: "Translating" Scientific Discovery.
Jeff Settleman, Robert L Cohen

Cell· March 2016

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Cancer: Bet on drug resistance.
Jeff Settleman

Nature· January 2016

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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Rushika M Perera, Svetlana Stoykova, Brandon N Nicolay, Kenneth N Ross, Julien Fitamant, Jeff Settleman

Nature· August 2015

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Adapting a drug screening platform to discover associations of molecular targeted radiosensitizers with genomic biomarkers.
Qi Liu, Meng Wang, Ashley M Kern, Saman Khaled, Jing Han, Jeff Settleman

Mol Cancer Res· April 2015

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Predicting response to HER2 kinase inhibition.
Jeff Settleman

Oncotarget· January 2015

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Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells.
Yuting Sun, Anneleen Daemen, Georgia Hatzivassiliou, David Arnott, Catherine Wilson, Jeff Settleman

Cancer Metab· November 2014

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Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition.
Catherine Wilson, Katrina Nicholes, Daisy Bustos, Eva Lin, Qinghua Song, Jeff Settleman

Oncotarget· September 2014

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