Publications by authors named "Arthur Taveras"

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CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia.
Chi Huu Nguyen, Katarina Zmajkovicova, Angelina Sekirnik, Sarah Taplin, Myriam Defontis, Arthur G Taveras

Front Immunol· December 2025

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Clinicopathologic Features and the Spectrum of Myelokathexis in Warts, Hypogammaglobulinemia, Infections, Myelokathexis Syndrome.
Jingwei Li, Marine Delecourt-Billet, Odile Fenneteau, Jadee L Neff, Lilian Roland, Arthur Taveras

Lab Invest· August 2025

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CXCR4 antagonism ameliorates leukocyte abnormalities in a preclinical model of WHIM syndrome.
Lilian Roland, Chi Huu Nguyen, Katarina Zmajkovicova, Mélanie Khamyath, Maria Kalogeraki, Arthur Taveras

Front Immunol· November 2024

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A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome.
Raffaele Badolato, Laia Alsina, Antoine Azar, Yves Bertrand, Audrey A Bolyard, Arthur G Taveras

Blood· July 2024

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A novel transmembrane CXCR4 variant that expands the WHIM genotype-phenotype paradigm.
Katarina Zmajkovicova, Sumit Pawar, Svetlana O Sharapova, Christoph B Geier, Ivana Wiest, Arthur G Taveras

Blood Adv· July 2024

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Disease Progression of WHIM Syndrome in an International Cohort of 66 Pediatric and Adult Patients.
Christoph B Geier, Maryssa Ellison, Rachel Cruz, Sumit Pawar, Alexander Leiss-Piller, Arthur G Taveras

J Clin Immunol· November 2022

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Genotype-phenotype correlations in WHIM syndrome: a systematic characterization of CXCR4 variants.
Katarina Zmajkovicova, Sumit Pawar, Sabine Maier-Munsa, Barbara Maierhofer, Ivana Wiest, Arthur G Taveras

Genes Immun· September 2022

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BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease.
Robert H Scannevin, Sowmya Chollate, Melanie S Brennan, Pamela A Snodgrass-Belt, Hairuo Peng, Arthur G Taveras

Neuropharmacology· April 2016

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Discovery of biaryl carboxylamides as potent RORγ inverse agonists.
Jianhua Chao, Istvan Enyedy, Kurt Van Vloten, Douglas Marcotte, Kevin Guertin, Arthur Taveras

Bioorg Med Chem Lett· August 2015

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Discovery and evaluation of a non-Zn chelating, selective matrix metalloproteinase 13 (MMP-13) inhibitor for potential intra-articular treatment of osteoarthritis.
Christian Gege, Bagna Bao, Harald Bluhm, Jürgen Boer, Brian M Gallagher, Arthur G Taveras

J Med Chem· January 2012

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Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.
Zhili Xin, Hairuo Peng, Andrew Zhang, Tina Talreja, Gnanasambandam Kumaravel, Arthur G Taveras

Bioorg Med Chem Lett· December 2011

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Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
Hairuo Peng, Tina Talreja, Zhili Xin, J Hernan Cuervo, Gnanasambandam Kumaravel, Arthur G Taveras

ACS Med Chem Lett· October 2011

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Design, synthesis, and biological evaluation of pyrazolopyrimidine-sulfonamides as potent multiple-mitotic kinase (MMK) inhibitors (part I).
Lin Zhang, Junhua Fan, Jer-Hong Chong, Angela Cesena, Betty Y Y Tam, Arthur G Taveras

Bioorg Med Chem Lett· September 2011

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Diaminocyclobutenediones as potent and orally bioavailable CXCR2 receptor antagonists: SAR in the phenolic amide region.
Cynthia Aki, Jianping Chao, Johan A Ferreira, Michael P Dwyer, Younong Yu, Arthur G Taveras

Bioorg Med Chem Lett· August 2009

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A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Vijaykumar M Baragi, Gabriel Becher, Alison M Bendele, Ralf Biesinger, Harald Bluhm, Arthur Taveras

Arthritis Rheum· July 2009

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Fluoroalkyl alpha side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists.
Purakkattle Biju, Arthur G Taveras, Michael P Dwyer, Younong Yu, Jianhua Chao

Bioorg Med Chem Lett· March 2009

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
Purakkattle Biju, Arthur G Taveras, Younong Yu, Junying Zheng, R William Hipkin

Bioorg Med Chem Lett· March 2009

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Extra binding region induced by non-zinc chelating inhibitors into the S1' subsite of matrix metalloproteinase 8 (MMP-8).
Giorgio Pochetti, Roberta Montanari, Christian Gege, Carine Chevrier, Arthur G Taveras

J Med Chem· February 2009

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Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists.
Gaifa Lai, J Robert Merritt, Zhenmin He, Daming Feng, Jianhua Chao, Arthur G Taveras

Bioorg Med Chem Lett· March 2008

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Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.
Younong Yu, Michael P Dwyer, Jianping Chao, Cynthia Aki, Jianhua Chao, Arthur Taveras

Bioorg Med Chem Lett· February 2008

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.
Purakkattle Biju, Arthur Taveras, Younong Yu, Junying Zheng, Jianhua Chao

Bioorg Med Chem Lett· January 2008

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C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists.
Jianhua Chao, Arthur G Taveras, Jianping Chao, Cynthia Aki, Michael Dwyer

Bioorg Med Chem Lett· July 2007

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Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.
Michael P Dwyer, Younong Yu, Jianping Chao, Cynthia Aki, Jianhua Chao, Arthur G Taveras

J Med Chem· December 2006

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Synthesis and structure-activity relationships of 3,4-diaminocyclobut-3-ene-1,2-dione CXCR2 antagonists.
J Robert Merritt, Laura L Rokosz, Kingsley H Nelson, Bernd Kaiser, Wei Wang, Arthur G Taveras

Bioorg Med Chem Lett· August 2006

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Sch-66336 (sarasar) and other benzocycloheptapyridyl farnesyl protein transferase inhibitors: discovery, biology and clinical observations.
Arthur G Taveras, Paul Kirschmeier, Charles M Baum

Curr Top Med Chem· June 2003

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