Publications by authors named "Axel J Scheidig"

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An ancient lysozyme in placozoans participates in acidic extracellular digestion.
Henry Berndt, Igor Duarte, Urska Repnik, Michel A Struwe, Mohammad Abukhalaf, Axel J Scheidig

Commun Biol· January 2026

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Protein - carbohydrate interaction studies using domestic animals as role models support the search of new glycomimetic molecules.
Ning Zhang, Lan Li, Marzieh Mohri, Simone Siebert, Thomas Lütteke, Axel J Scheidig

Int J Biol Macromol· November 2024

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Second-Coordination-Sphere Effects Reveal Electronic Structure Differences between the Mitochondrial Amidoxime Reducing Component and Sulfite Oxidase.
Michel A Struwe, Jing Yang, Kubandiran Kolanji, Joshua Mengell, Axel J Scheidig

Inorg Chem· October 2024

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mARC1 Is the Main Contributor to Metabolic Reduction of -Hydroxyurea.
Cathrin Klopp, Xiaomei Zhang, Morgan K Campbell, David Kvaskoff, Michel A Struwe, Axel J Scheidig

J Med Chem· October 2024

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mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
Amanda K Jones, Besnik Bajrami, Morgan K Campbell, Abdullah Mesut Erzurumluoglu, Qiusha Guo, Axel J Scheidig

Hepatol Commun· May 2024

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The mitochondrial amidoxime reducing component-from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target.
Michel A Struwe, Axel J Scheidig, Bernd Clement

J Biol Chem· November 2023

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New Design of an Activity Assay Suitable for High-Throughput Screening of Substrates and Inhibitors of the Mitochondrial Amidoxime Reducing Component (mARC).
Cathrin Klopp, Michel A Struwe, Christoph Plieth, Bernd Clement, Axel J Scheidig

Anal Chem· August 2023

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Reduction of Hydrogen Peroxide by Human Mitochondrial Amidoxime Reducing Component Enzymes.
Sophia Rixen, Patrick M Indorf, Christian Kubitza, Michel A Struwe, Cathrin Klopp, Axel J Scheidig

Molecules· August 2023

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Identification of New Antibodies Targeting Malignant Plasma Cells for Immunotherapy by Next-Generation Sequencing-Assisted Phage Display.
Steffen Krohn, Ammelie Svea Boje, Carina Lynn Gehlert, Sebastian Lutz, Nikos Darzentas, Axel J Scheidig

Front Immunol· July 2022

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WHIRLY1 of Barley and Maize Share a PRAPP Motif Conferring Nucleoid Compaction.
Svenja Oetke, Axel J Scheidig, Karin Krupinska

Plant Cell Physiol· February 2022

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Structural and catalytic characterization of Blastochloris viridis and Pseudomonas aeruginosa homospermidine synthases supports the essential role of cation-π interaction.
F Helfrich, Axel J Scheidig

Acta Crystallogr D Struct Biol· October 2021

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Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates.
Patrick Indorf, Christian Kubitza, Axel J Scheidig, Thomas Kunze, Bernd Clement

J Med Chem· June 2020

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KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases.
Anne-Kathrin Bartels, Sascha Göttert, Christine Desel, Miriam Schäfer, Sebastian Krossa, Axel J Scheidig

Cell Physiol Biochem· April 2019

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Nanomedical Relevance of the Intermolecular Interaction Dynamics-Examples from Lysozymes and Insulins.
Ruiyan Zhang, Ning Zhang, Marzieh Mohri, Lisha Wu, Thomas Eckert, Axel J Scheidig

ACS Omega· February 2019

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Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes.
Christian Kubitza, Florian Bittner, Carsten Ginsel, Antje Havemeyer, Bernd Clement, Axel J Scheidig

Proc Natl Acad Sci U S A· November 2018

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The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids.
Carsten Ginsel, Birte Plitzko, Danilo Froriep, Diana A Stolfa, Manfred Jung, Axel J Scheidig

Drug Metab Dispos· October 2018

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T4 lysozyme-facilitated crystallization of the human molybdenum cofactor-dependent enzyme mARC.
Christian Kubitza, Carsten Ginsel, Florian Bittner, Antje Havemeyer, Bernd Clement, Axel J Scheidig

Acta Crystallogr F Struct Biol Commun· June 2018

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Crystal structure of pyrrolizidine alkaloid N-oxygenase from the grasshopper Zonocerus variegatus.
Christian Kubitza, Annette Faust, Miriam Gutt, Luzia Gäth, Dietrich Ober, Axel J Scheidig

Acta Crystallogr D Struct Biol· May 2018

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Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.
Michael Kisiela, Annette Faust, Bettina Ebert, Edmund Maser, Axel J Scheidig

FEBS J· January 2018

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Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17.
Sebastian Krossa, Axel J Scheidig, Joachim Grötzinger, Inken Lorenzen

Sci Rep· January 2018

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GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.
Miriam Schäfer, Daniela C Granato, Sebastian Krossa, Anne-Kathrin Bartels, Sami Yokoo, Axel J Scheidig

FEBS Lett· November 2017

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Lysozyme's lectin-like characteristics facilitates its immune defense function.
Ruiyan Zhang, Lisha Wu, Thomas Eckert, Monika Burg-Roderfeld, Miguel A Rojas-Macias, Axel J Scheidig

Q Rev Biophys· January 2017

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Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer.
Renato H-J Weiße, Annette Faust, Marcel Schmidt, Peter Schönheit, Axel J Scheidig

Proc Natl Acad Sci U S A· February 2016

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Comprehensive Structural Characterization of the Bacterial Homospermidine Synthase-an Essential Enzyme of the Polyamine Metabolism.
Sebastian Krossa, Annette Faust, Dietrich Ober, Axel J Scheidig

Sci Rep· January 2016

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Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1.
Sebastian Krossa, Anne Dorothée Schmitt, Kirsten Hattermann, Jürgen Fritsch, Axel J Scheidig

Oncotarget· August 2015

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