Publications by authors named "Bernd Clement"

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[Scientific basics of pharmacist education].
Bernd Clement

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz· May 2025

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and Pharmacokinetic Studies of a Dual Topoisomerase I/II Inhibitor.
Jonas Hildebrandt, Dirk O Bauerschlag, Gert Fricker, Ulrich Girreser, Björn Konukiewitz, Bernd Clement

ACS Pharmacol Transl Sci· April 2025

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Dual Topoisomerase Inhibitor Is Highly Potent and Improves Antitumor Response to Radiotherapy in Cervical Carcinoma.
Inken Flörkemeier, Hannah L Hotze, Anna Lena Heyne, Jonas Hildebrandt, Jörg P Weimer, Bernd Clement

Int J Mol Sci· March 2025

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Second-Coordination-Sphere Effects Reveal Electronic Structure Differences between the Mitochondrial Amidoxime Reducing Component and Sulfite Oxidase.
Michel A Struwe, Jing Yang, Kubandiran Kolanji, Joshua Mengell, Axel J Scheidig, Bernd Clement

Inorg Chem· October 2024

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mARC1 Is the Main Contributor to Metabolic Reduction of -Hydroxyurea.
Cathrin Klopp, Xiaomei Zhang, Morgan K Campbell, David Kvaskoff, Michel A Struwe, Bernd Clement

J Med Chem· October 2024

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mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes.
Amanda K Jones, Besnik Bajrami, Morgan K Campbell, Abdullah Mesut Erzurumluoglu, Qiusha Guo, Bernd Clement

Hepatol Commun· May 2024

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The mitochondrial amidoxime reducing component-from prodrug-activation mechanism to drug-metabolizing enzyme and onward to drug target.
Michel A Struwe, Axel J Scheidig, Bernd Clement

J Biol Chem· November 2023

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New Design of an Activity Assay Suitable for High-Throughput Screening of Substrates and Inhibitors of the Mitochondrial Amidoxime Reducing Component (mARC).
Cathrin Klopp, Michel A Struwe, Christoph Plieth, Bernd Clement, Axel J Scheidig

Anal Chem· August 2023

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Reduction of Hydrogen Peroxide by Human Mitochondrial Amidoxime Reducing Component Enzymes.
Sophia Rixen, Patrick M Indorf, Christian Kubitza, Michel A Struwe, Cathrin Klopp, Bernd Clement

Molecules· August 2023

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The History of mARC.
Bernd Clement, Michel A Struwe

Molecules· June 2023

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Active Site Structures of the -Hydroxylaminopurine Resistance Molybdoenzyme YcbX.
Jing Yang, Michel Struwe, Axel Scheidig, Joshua Mengell, Bernd Clement

Inorg Chem· April 2023

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Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.
Michel A Struwe, Bernd Clement, Axel Scheidig

Hepatol Commun· November 2022

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Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer.
Inken Flörkemeier, Julia S Hillmann, Jörg P Weimer, Jonas Hildebrandt, Nina Hedemann, Bernd Clement

Int J Mol Sci· September 2022

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Enzyme Electrode Biosensors for -Hydroxylated Prodrugs Incorporating the Mitochondrial Amidoxime Reducing Component.
Joan Zapiter, Jeffrey R Harmer, Michel Struwe, Axel Scheidig, Bernd Clement

Anal Chem· June 2022

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The Novel Dual Topoisomerase Inhibitor P8-D6 Shows Anti-myeloma Activity and .
Katja Klausz, Christian Kellner, Carina Lynn Gehlert, Steffen Krohn, Hauke Wilcken, Bernd Clement

Mol Cancer Ther· January 2022

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High Antitumor Activity of the Dual Topoisomerase Inhibitor P8-D6 in Breast Cancer.
Inken Flörkemeier, Tamara N Steinhauer, Nina Hedemann, Jörg Paul Weimer, Christoph Rogmans, Bernd Clement

Cancers (Basel)· December 2021

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Newly developed dual topoisomerase inhibitor P8-D6 is highly active in ovarian cancer.
Inken Flörkemeier, Tamara N Steinhauer, Nina Hedemann, Magnus Ölander, Per Artursson, Bernd Clement

Ther Adv Med Oncol· November 2021

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Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes.
Michel A Struwe, Palraj Kalimuthu, Zhenyao Luo, Qifeng Zhong, Daniel Ellis, Bernd Clement

J Biol Chem· August 2021

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A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential.
Cristina Maccallini, Lisa Marinelli, Patrick Indorf, Ivana Cacciatore, Marialuigia Fantacuzzi, Bernd Clement

ChemMedChem· November 2020

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Drug Metabolism by the Mitochondrial Amidoxime Reducing Component (mARC): Rapid Assay and Identification of New Substrates.
Patrick Indorf, Christian Kubitza, Axel J Scheidig, Thomas Kunze, Bernd Clement

J Med Chem· June 2020

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The Aza-Analogous Benzo[]phenanthridine P8-D6 Acts as a Dual Topoisomerase I and II Poison, thus Exhibiting Potent Genotoxic Properties.
Georg Aichinger, Falk-Bach Lichtenberger, Tamara N Steinhauer, Inken Flörkemeier, Giorgia Del Favero, Bernd Clement

Molecules· March 2020

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Discovery of -(4-Aminobutyl)-'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (DDAH-1).
Ina Lunk, Felix-Alexander Litty, Sven Hennig, Ingrid R Vetter, Jürke Kotthaus, Bernd Clement

J Med Chem· January 2020

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Mitochondrial amidoxime-reducing component 2 (MARC2) has a significant role in -reductive activity and energy metabolism.
Sophia Rixen, Antje Havemeyer, Anita Tyl-Bielicka, Kazimiera Pysniak, Marta Gajewska, Bernd Clement

J Biol Chem· November 2019

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Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes.
Christian Kubitza, Florian Bittner, Carsten Ginsel, Antje Havemeyer, Bernd Clement

Proc Natl Acad Sci U S A· November 2018

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The Involvement of the Mitochondrial Amidoxime Reducing Component (mARC) in the Reductive Metabolism of Hydroxamic Acids.
Carsten Ginsel, Birte Plitzko, Danilo Froriep, Diana A Stolfa, Manfred Jung, Bernd Clement

Drug Metab Dispos· October 2018

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