Publications by authors named "Azin Nezami"

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Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit.
Randal A Byrn, Steven M Jones, Hamilton B Bennett, Chris Bral, Michael P Clark, Azin Nezami

Antimicrob Agents Chemother· March 2015

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Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
Michael P Clark, Mark W Ledeboer, Ioana Davies, Randal A Byrn, Steven M Jones, Azin Nezami

J Med Chem· August 2014

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Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.
Justin T Ernst, Timothy Neubert, Michael Liu, Samuel Sperry, Harmon Zuccola, Azin Nezami

J Med Chem· April 2014

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Tubulin binding, protein-bound conformation in solution, and antimitotic cellular profiling of noscapine and its derivatives.
Youssef L Bennani, Wenxin Gu, Angeles Canales, Fernando J Díaz, Brenda K Eustace, Azin Nezami

J Med Chem· March 2012

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Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins.
Azin Nezami, Florence Poy, Angela Toms, Wei Zheng, Michael J Eck

PLoS One· September 2010

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Structure of the autoinhibitory switch in formin mDia1.
Azin G Nezami, Florence Poy, Michael J Eck

Structure· February 2006

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Transient state kinetics of enzyme IICBGlc, a glucose transporter of the phosphoenolpyruvate phosphotransferase system of Escherichia coli: equilibrium and second order rate constants for the glucose binding and phosphotransfer reactions.
Norman D Meadow, Regina S Savtchenko, Azin Nezami, Saul Roseman

J Biol Chem· December 2005

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Search for substrate-based inhibitors fitting the S2' space of malarial aspartic protease plasmepsin II.
Aiko Kiso, Koushi Hidaka, Tooru Kimura, Yoshio Hayashi, Azin Nezami

J Pept Sci· November 2004

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Design of inhibitors against HIV, HTLV-I, and Plasmodium falciparum aspartic proteases.
Hamdy M Abdel-Rahman, Tooru Kimura, Koushi Hidaka, Aiko Kiso, Azin Nezami

Biol Chem· November 2004

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Isothermal titration calorimetry.
Adrián Velázquez-Campoy, Hiroyasu Ohtaka, Azin Nezami, Salman Muzammil, Ernesto Freire

Curr Protoc Cell Biol· September 2004

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Crystallization and preliminary X-ray characterization of the relaxase domain of F factor TraI.
Chris Larkin, Saumen Datta, Azin Nezami, Julie A Dohm, Joel F Schildbach

Acta Crystallogr D Biol Crystallogr· August 2003

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High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor.
Azin Nezami, Tooru Kimura, Koushi Hidaka, Aiko Kiso, Jun Liu

Biochemistry· July 2003

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The integration of genomic and structural information in the development of high affinity plasmepsin inhibitors.
Azin Nezami, Ernesto Freire

Int J Parasitol· December 2002

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Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.
Azin Nezami, Irene Luque, Tooru Kimura, Yoshiaki Kiso, Ernesto Freire

Biochemistry· February 2002

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