Publications by authors named "Benjamin A Nacev"

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ATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survival.
Kathryn Demanelis, Julia Leix, Melissa A Burgess, Benjamin A Nacev

medRxiv· November 2025

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High transposable element expression in sarcomas is associated with increased immune infiltrates and improved outcomes including after immunotherapy.
Benjamin A Nacev, Martina Bradic, Hyung Jun Woo, Allison L Richards, Ciara M Kelly

J Immunother Cancer· September 2025

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Methylation Analysis Reveals Epigenetic Congruence Between Bone Sarcomas With H3-3A Mutations and Malignant Giant Cell Tumors of Bone.
Carla Saoud, Jamal Benhamida, Laetitia Borsu, Liliana Villafania, Konstantinos Linos, Benjamin A Nacev

Mod Pathol· July 2025

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Novel dual gene fusions identified in a late pulmonary metastasis of an infantile fibrosarcoma-like tumor.
Karen Schoedel, Shaymaa Hegazy, Megan L Zilla, Jason Chang, Benjamin A Nacev

Virchows Arch· May 2025

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ACR-368, a CHK1/2 Kinase Inhibitor, in Patients With Relapsed or Refractory Desmoplastic Small Round Cell Tumor: Phase I/II Trial Results.
Emily K Slotkin, Audrey Mauguen, Filemon S Dela Cruz, Michael V Ortiz, Viswatej Avutu, Benjamin A Nacev

JCO Oncol Adv· April 2025

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Detection of Alternative Lengthening of Telomeres via Chromogenic In Situ Hybridization for the Prognostication of PanNETs and Other Neoplasms.
Christopher M Heaphy, Simmi Patel, Katelyn Smith, Anne R Wondisford, Michelle L Lynskey, Benjamin A Nacev

Mod Pathol· March 2025

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Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.
Dezhi Li, Ke Geng, Yuan Hao, Jiajia Gu, Saurav Kumar, Benjamin A Nacev

J Clin Invest· December 2024

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Author Correction: Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.
Benjamin A Nacev, Yakshi Dabas, Matthew R Paul, Christian Pacheco, Michelle Mitchener

Nat Commun· October 2024

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Cancer-associated Histone H3 N-terminal arginine mutations disrupt PRC2 activity and impair differentiation.
Benjamin A Nacev, Yakshi Dabas, Matthew R Paul, Christian Pacheco, Michelle Mitchener

Nat Commun· June 2024

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ATRX guards against aberrant differentiation in mesenchymal progenitor cells.
Yan Fang, Douglas Barrows, Yakshi Dabas, Thomas S Carroll, Sam Singer, Benjamin A Nacev

Nucleic Acids Res· May 2024

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Stereotactic body radiation therapy for sarcoma pulmonary metastases.
Emily S Lebow, Stephanie M Lobaugh, Zhigang Zhang, Mark A Dickson, Evan Rosenbaum, Benjamin A Nacev

Radiother Oncol· October 2023

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Immune-related Adverse Events after Immune Checkpoint Blockade-based Therapy Are Associated with Improved Survival in Advanced Sarcomas.
Evan Rosenbaum, Kenneth Seier, Martina Bradic, Ciara Kelly, Sujana Movva, Benjamin A Nacev

Cancer Res Commun· October 2023

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ATRX guards against aberrant differentiation in mesenchymal progenitor cells.
Yan Fang, Douglas Barrows, Yakshi Dabas, Thomas S Carroll, William D Tap, Benjamin A Nacev

bioRxiv· August 2023

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A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma.
Ciara M Kelly, Li-Xuan Qin, Karissa A Whiting, Allison L Richards, Viswatej Avutu, Benjamin A Nacev

Clin Cancer Res· June 2023

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The genetic landscape of SMARCB1 alterations in SMARCB1-deficient spectrum of mesenchymal neoplasms.
Josephine K Dermawan, Samuel Singer, William D Tap, Benjamin A Nacev, Ping Chi

Mod Pathol· December 2022

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Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets.
Benjamin A Nacev, Francisco Sanchez-Vega, Shaleigh A Smith, Cristina R Antonescu, Evan Rosenbaum

Nat Commun· June 2022

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Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors.
Ping Chi, Li-Xuan Qin, Niedzica Camacho, Ciara M Kelly, Sandra P D'Angelo, Benjamin A Nacev

Clin Cancer Res· April 2022

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Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma.
Nicholas D Klemen, Sinchun Hwang, Martina Bradic, Evan Rosenbaum, Mark A Dickson, Benjamin A Nacev

Clin Cancer Res· March 2022

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Phase II Trial of Imatinib Plus Binimetinib in Patients With Treatment-Naive Advanced Gastrointestinal Stromal Tumor.
Ping Chi, Li-Xuan Qin, Bastien Nguyen, Ciara M Kelly, Sandra P D'Angelo, Benjamin A Nacev

J Clin Oncol· March 2022

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A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma.
Christina V Angeles, Ana Velez, Jordan Rios, Bernadette Laxa, David Shum, Benjamin A Nacev

Clin Cancer Res· January 2022

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Oncohistone mutations enhance chromatin remodeling and alter cell fates.
John D Bagert, Michelle M Mitchener, Agata L Patriotis, Barbara E Dul, Felix Wojcik, Benjamin A Nacev

Nat Chem Biol· April 2021

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The epigenomics of sarcoma.
Benjamin A Nacev, Kevin B Jones, Andrew M Intlekofer, Jamie S E Yu, C David Allis

Nat Rev Cancer· October 2020

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The expanding landscape of 'oncohistone' mutations in human cancers.
Benjamin A Nacev, Lijuan Feng, John D Bagert, Agata E Lemiesz, JianJiong Gao

Nature· March 2019

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TOMAS: revisiting PARP inhibitor combination therapy.
Benjamin A Nacev, William D Tap

Lancet Oncol· October 2018

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Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.
Sarah A Head, Wei Q Shi, Eun Ju Yang, Benjamin A Nacev, Sam Y Hong

ACS Chem Biol· January 2017

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