Publications by authors named "Benjamin Combs"

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BioID2-Based Tau Interactome Reveals Novel and Known Protein Interactions Associated with Multiple Cellular Pathways.
Ahmed Atwa, Mohammed M Alhadidy, Jared Lamp, Benjamin Combs, Nicholas M Kanaan

J Proteome Res· October 2025

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Seeding Alzheimer's disease-associated tau pathology in MAPT knock-in primary neurons causes early axonopathy and synaptic dysfunction.
Rebecca L Mueller, Benjamin Combs, Nicholas M Kanaan

Sci Rep· October 2025

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Using Live-Cell Imaging to Measure the Effects of Pathological Proteins on Axonal Transport in Primary Hippocampal Neurons.
Rebecca L Mueller, Nicholas M Kanaan, Benjamin Combs

J Vis Exp· December 2023

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Phosphomimetics at Ser199/Ser202/Thr205 in Tau Impairs Axonal Transport in Rat Hippocampal Neurons.
Kyle R Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M Alhadidy

Mol Neurobiol· June 2023

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Age-dependent accumulation of tau aggregation in .
Wendy Aquino Nunez, Benjamin Combs, T Chris Gamblin, Brian D Ackley

Front Aging· August 2022

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Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism.
Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller

J Neurosci· November 2021

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Tau: A Signaling Hub Protein.
Rebecca L Mueller, Benjamin Combs, Mohammed M Alhadidy, Scott T Brady, Gerardo A Morfini

Front Mol Neurosci· March 2021

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Liquid-liquid phase separation induces pathogenic tau conformations in vitro.
Nicholas M Kanaan, Chelsey Hamel, Tessa Grabinski, Benjamin Combs

Nat Commun· June 2020

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Tau and Axonal Transport Misregulation in Tauopathies.
Benjamin Combs, Rebecca L Mueller, Gerardo Morfini, Scott T Brady, Nicholas M Kanaan

Adv Exp Med Biol· April 2020

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FTDP-17 Mutations Alter the Aggregation and Microtubule Stabilization Propensity of Tau in an Isoform-Specific Fashion.
Yamini Mutreja, Benjamin Combs, T Chris Gamblin

Biochemistry· February 2019

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Attenuated Herpes Simplex Virus 1 (HSV-1) Expressing a Mutant Form of ICP6 Stimulates a Strong Immune Response That Protects Mice against HSV-1-Induced Corneal Disease.
David J Davido, Eleain M Tu, Hong Wang, Maria Korom, Andreu Gazquez Casals, Benjamin Combs

J Virol· September 2018

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Production of recombinant tau oligomers in vitro.
Benjamin Combs, Chelsea T Tiernan, Chelsey Hamel, Nicholas M Kanaan

Methods Cell Biol· June 2018

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Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.
Andrew Kneynsberg, Benjamin Combs, Kyle Christensen, Gerardo Morfini, Nicholas M Kanaan

Front Neurosci· October 2017

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Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies.
Benjamin Combs, Nicholas M Kanaan

Am J Pathol· June 2017

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Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition.
Kristine Cox, Benjamin Combs, Brenda Abdelmesih, Gerardo Morfini, Scott T Brady

Neurobiol Aging· November 2016

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Gene Therapy Models of Alzheimer's Disease and Other Dementias.
Benjamin Combs, Andrew Kneynsberg, Nicholas M Kanaan

Methods Mol Biol· October 2016

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Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies.
Benjamin Combs, Chelsey Hamel, Nicholas M Kanaan

Neurobiol Dis· October 2016

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Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.
Chelsea T Tiernan, Benjamin Combs, Kristine Cox, Gerardo Morfini, Scott T Brady

Exp Neurol· September 2016

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FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions.
Benjamin Combs, T Chris Gamblin

Biochemistry· October 2012

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Hsp70 alters tau function and aggregation in an isoform specific manner.
Kellen Voss, Benjamin Combs, Kristina R Patterson, Lester I Binder, T Chris Gamblin

Biochemistry· January 2012

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Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation.
Christopher L Moore, Michael H Huang, Shauna A Robbennolt, Kellen R Voss, Benjamin Combs

Biochemistry· December 2011

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Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms.
Benjamin Combs, Kellen Voss, T Chris Gamblin

Biochemistry· November 2011

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Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
Kristina R Patterson, Sarah M Ward, Benjamin Combs, Kellen Voss, Nicholas M Kanaan

Biochemistry· November 2011

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