Publications by authors named "Benjamin Cravatt"

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Pharmacological targeting of the JAK-STAT pathway: new concepts and emerging indications.
Teemu Haikarainen, Anniina T Virtanen, Benjamin F Cravatt, Olli Silvennoinen

Nat Rev Drug Discov· January 2026

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Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5.
F Wieland Goetzke, Steffen M Bernard, Cheng-Wei Ju, Jonathan Pollock, Kristen E DeMeester, Benjamin F Cravatt

Nat Chem Biol· January 2026

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Mapping cellular targets of covalent cancer drugs in the entire mammalian body.
Zhengyuan Pang, Verina H Leung, Cailynn C Wang, Ahmadreza Attarpour, Anthony Rinaldi, Benjamin F Cravatt

Cell· December 2025

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Development of a novel F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography.
Jian Rong, Chunyu Zhao, Ahmad F Chaudhary, Tim Ware, Richard S Van, Benjamin F Cravatt

Acta Pharm Sin B· December 2025

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Cathepsin C-Catalyzed Ligation Generates Intralysosomal Amyloid Fibrils from Dipeptide Esters.
Ruben D Elias, Robert T O'Neill, Idil I Demiralp, Seth Allen, Daniel Serwas, Benjamin F Cravatt

bioRxiv· December 2025

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Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function.
Benjamin J Jenkins, Yasmin R Jenkins, Fernando M Ponce-Garcia, Chloe Moscrop, Iain A Perry, Benjamin F Cravatt

Nat Commun· November 2025

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Cysteine allostery and autoinhibition govern human STING oligomer functionality.
Rebecca Chan, Xujun Cao, Sabrina L Ergun, Evert Njomen, Stephen R Lynch, Benjamin Cravatt

Nat Chem Biol· October 2025

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Scalable total synthesis of saxitoxin and related natural products.
Yinliang Guo, Yiheng Li, Sihan Chen, Yige Wu, Oscar Poll, Benjamin F Cravatt

Nature· October 2025

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A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition.
Paige A Barta, Leopold Garnar-Wortzel, Timothy R Bishop, Rachel E Hayward, Lauren M Hargis, Benjamin F Cravatt

RSC Chem Biol· October 2025

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Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex.
Rachel E Hayward, Raymond F Berkeley, Zijian Gao, Maximilian Garhammer, Marc A Morizono, Benjamin F Cravatt

bioRxiv· October 2025

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High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity.
James B Shaum, Miquel Muñoz I Ordoño, Erica A Steen, Daniela V Wenge, Hakyung Cheong, Benjamin F Cravatt

bioRxiv· September 2025

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Cysteine reactivity profiling identifies host regulators of replication in human macrophages.
John Neff, Kristen E DeMeester, Paola K Parraga, Radu Suciu, Melissa Dix, Benjamin F Cravatt

bioRxiv· September 2025

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Erucamide regulates retinal neurovascular crosstalk.
Guoqin Wei, Shreyosree Chatterjee, Qinglin Yang, Sanahan Vijayakumar, Daisuke Ogasawara, Benjamin Cravatt

bioRxiv· September 2025

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NONO Maintains SREBP-Regulated Cholesterol Biosynthesis via RNA Binding in Neuroblastoma.
Song Zhang, Hayley Ingram, Jack Cooper, Alina Naveed, Stefan G Kathman, Benjamin F Cravatt

FASEB J· September 2025

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A chemical-genetic interaction between PAF1 and ENL/AF9 YEATS inhibition.
Paige A Barta, Leopold Garnar-Wortzel, Timothy R Bishop, Rachel E Hayward, Lauren M Hargis, Benjamin F Cravatt

bioRxiv· September 2025

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Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.
Arthur S Kim, Kevin Ma, Christopher J Reinhardt, Daniel C Lazar, Daisuke Ogasawara, Benjamin F Cravatt

bioRxiv· August 2025

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Dietary control of peripheral adipose storage capacity through membrane lipid remodelling.
Marcus J Tol, Yuta Shimanaka, Alexander H Bedard, Jennifer Sapia, Liujuan Cui, Benjamin F Cravatt

Nat Metab· July 2025

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A global genetic interaction map of a human cell reveals conserved principles of genetic networks.
Maximilian Billmann, Michael Costanzo, Xiang Zhang, Arshia Z Hassan, Mahfuzur Rahman, Benjamin F Cravatt

bioRxiv· July 2025

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Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes.
Michael Bielecki, Molhm Nassir, Hayden A Sharma, Nathanyal J Truax, Nicholas Raheja, Benjamin F Cravatt

J Am Chem Soc· June 2025

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Structural and mechanistic analysis of covalent ligands targeting the RNA-binding protein NONO.
Garrett L Lindsey, Thomas K Hockley, Alejandro Villa Gomez, Andew C Marshall, William R Brothers, Benjamin F Cravatt

bioRxiv· June 2025

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Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors.
Hayden A Sharma, Michael Bielecki, Meredith A Holm, Ty M Thompson, Yue Yin, Jacob B Cravatt, Benjamin F Cravatt

J Am Chem Soc· May 2025

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A cold-inducible phospholipid-protein interaction in brown fat mitochondria optimizes thermogenic capacity.
Yuta Shimanaka, Marcus J Tol, Christian Rocha-Roa, Matthew J Jellinek, Liujuan Cui, Benjamin F Cravatt

bioRxiv· May 2025

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Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5.
F Wieland Goetzke, Steffen M Bernard, Cheng-Wei Ju, Jonathan Pollock, Kristen E DeMeester, Benjamin F Cravatt

bioRxiv· May 2025

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Mapping cellular targets of covalent cancer drugs in the entire mammalian body.
Zhengyuan Pang, Verina H Leung, Cailynn C Wang, Ahmadreza Attarpour, Anthony Rinaldi, Benjamin F Cravatt

bioRxiv· April 2025

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ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity.
Benjamin J Jenkins, Yasmin R Jenkins, Fernando M Ponce-Garcia, Chloe Moscrop, Iain A Perry, Benjamin F Cravatt

bioRxiv· March 2025

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