Publications by authors named "Benjamin D Horning"

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Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers.
Shota Kikuchi, Jason C Green, Don C Rogness, Betty Lam, Zachary A Owyang, Benjamin D Horning

J Med Chem· December 2025

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A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth.
Nilotpal Roy, Tine Wyseure, I-Chung Lo, Justine Lu, Christie L Eissler, Benjamin D Horning

Cancer Discov· December 2025

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Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2.
Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A Hoffman, Benjamin D Horning

Science· November 2025

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Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2.
Joseph E Klebba, Nilotpal Roy, Steffen M Bernard, Stephanie Grabow, Melissa A Hoffman, Benjamin D Horning

bioRxiv· December 2024

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Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Madeline E Kavanagh, Benjamin D Horning, Roli Khattri, Nilotpal Roy, Justine P Lu

Nat Chem Biol· December 2022

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Author Correction: Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine.
Madeline E Kavanagh, Benjamin D Horning, Roli Khattri, Nilotpal Roy, Justine P Lu

Nat Chem Biol· November 2022

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Covalent inhibitors of nicotinamide N-methyltransferase (NNMT) provide evidence for target engagement challenges in situ.
Hsin-Yu Lee, Radu M Suciu, Benjamin D Horning, Ekaterina V Vinogradova, Olesya A Ulanovskaya

Bioorg Med Chem Lett· September 2018

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Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer.
Liron Bar-Peled, Esther K Kemper, Radu M Suciu, Ekaterina V Vinogradova, Keriann M Backus, Benjamin D Horning

Cell· October 2017

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Chemoproteomic profiling and discovery of protein electrophiles in human cells.
Megan L Matthews, Lin He, Benjamin D Horning, Erika J Olson, Bruno E Correia

Nat Chem· March 2017

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Chemical Proteomic Profiling of Human Methyltransferases.
Benjamin D Horning, Radu M Suciu, Darian A Ghadiri, Olesya A Ulanovskaya, Megan L Matthews

J Am Chem Soc· October 2016

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Proteome-wide covalent ligand discovery in native biological systems.
Keriann M Backus, Bruno E Correia, Kenneth M Lum, Stefano Forli, Benjamin D Horning

Nature· June 2016

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Nine-step enantioselective total synthesis of (-)-vincorine.
Benjamin D Horning, David W C MacMillan

J Am Chem Soc· May 2013

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